<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11895

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKLQVNQKDNFWLVTPRSQSAINTWFTDLAGTKPLTQLAKVPIFSKKDEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNALGPFIEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCSSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGSSKDGHEISDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPSAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPAVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTANNMPSNSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVTNWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGECQSDSLEKVHQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPAIKTEDYSMGSGRSGPYGVTVPPDLLHHANPGSMSHLSYRQGSMSLYTQNQPLPAGGPRVDPYRPMRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSYKASVYRQQQPTVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMAPLNAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQILREQSQQQQQQQQQQQQQQQQQQQPPPPQQPHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2183
PositionKinase
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index57.77
Isoelectric point6.59
Molecular weight243645.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP11895
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     188.26|      15|      15|    2049|    2063|       1
---------------------------------------------------------------------------
 2049- 2063 (36.27/13.44)	QQQQQ...QQQQ....Q....QQQQQ
 2066- 2080 (36.27/13.44)	QQQQQ...QQQQ....Q....QQQQQ
 2086- 2103 (27.42/ 8.46)	QQQQQilrEQSQ....Q....QQQQQ
 2104- 2118 (34.50/12.44)	QQQQQ...QQQQ....Q....QQPPP
 2120- 2138 (28.90/ 9.29)	QQPHQ...QQQQ....QaappQPQPQ
 2149- 2167 (24.91/ 7.04)	QQTQQ...QQQTaalvR....QLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     323.19|     115|     155|    1128|    1282|       2
---------------------------------------------------------------------------
 1127- 1263 (170.96/160.26)	LATfvailIARQ......CL..LLED.......LIRCAAIPSLLNAACSEQ...DSEPGarltcrillhlfKTPQLNPCQS.DGNKPAVGIR.SSCDRHLL.AASQNRIVDGAVFAVLKA...VFvLGDAElKGSGftvTGGT.EELPEEEGGGG..SGGRRQG
 1282- 1423 (152.23/79.32)	LRS.....ICQQewvgerCLksLCEDsndlqdpVLSSAQAQRLMQLICYPHrllDNEDG............ENPQRQRIKRiLQNLDQWTMRqSSLELQLMiKQTPNNEMNSLLENIAKAtieVF.QQSAE.TGSS...SGSTaNNMPSNSKTKPvlSSLERSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     190.72|      37|      48|    1804|    1840|       3
---------------------------------------------------------------------------
 1804- 1837 (57.79/29.83)	...................GSGR......SGPY.GVTVP...PDLL..HH.ANPGSMSHLSYRQGS
 1838- 1884 (39.35/17.42)	MSL.......ytqnqplpaGGPR......VDPYrPMRLP...MQKLptRP.TYPGVLP..TTMTGV
 1885- 1942 (38.54/16.87)	MGLepsykasvyrqqqptvPQGQrlrqqlQQSQ.GM.LG...QSSV..HQ.MTPSSSYGLQTSQGY
 1967- 1992 (22.76/ 6.25)	......................S......SQPY.QSTHPstnPTLV......DP..TRHLQQR...
 1994- 2023 (32.28/12.66)	.............................SG.Y.VHQQA...PTYG..HGlTSTQRFSHQTLQQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     352.50|     119|     160|    1424|    1561|       4
---------------------------------------------------------------------------
 1424- 1561 (170.86/206.09)	VWLVAPLIAKLPTSVQGHVlkaagEElEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSL......VLTClkgqdEQREGLL.......ASLHS....QVHQIVTnwreNQYLddcKPKQLMhEALKLRLNLVGGMFDTVQ..RSTQQTTEWAVLLL
 1587- 1724 (181.64/153.13)	VLINGTLAADMSSISQGSM.....EE.NKRAYMNLVKKLQKELGECQSDSLEKVHQLLPLpkqtrdVITC.....EPQGSLIdtkgnkiAGFDSifkkEGLQVST....KQKI...SPWDLF.EGLKPSAPLSWGWFGTVRvdRRVARGEEQQRLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.67|      30|     155|     921|     957|       6
---------------------------------------------------------------------------
  923-  957 (42.48/45.61)	LCivAVLRHYhaCLILNQDQMAqVFEGLCGVVKHG
 1076- 1105 (56.19/31.35)	LC..AELTGY..CKSLSAEWLG.VLKALCCSSNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.61|      18|      30|    1731|    1749|      16
---------------------------------------------------------------------------
  680-  696 (28.34/12.49)	K.PDFSLFSP.TMPCEGKG
 1731- 1749 (29.34/17.86)	PrPRAYYLEPLPLPPEDEE
 1750- 1764 (21.92/ 7.75)	P.PAPTLLEPEKKAPE...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11895 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGTAPPSTEERKKKSTKGKKRSQPAIKTEDYSMGSGRSGPYGVTVPPDLLHHANPGSMSHLSYRQGSMSLYTQNQPLPAGGPRVDPYRPMRLPMQKLPTRPTYPGVLPTTMTGV
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
5) LEPSYKASVYRQQQPTVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTS
6) QQQQQQQQQQQPPPPQQPHQQQQQQAAPPQPQPQSQPQFQRQGLQ
7) VLKAAGEELEKGQHLGSSSRKERDRQKQKS
8) YVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMAPLNAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQ
1735
686
626
15
1887
2105
1442
1945
1884
725
673
59
1939
2149
1471
2069










Molecular Recognition Features






MoRF SequenceStartStop




1) IFGRY
2179
2183