<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11892

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIPQLQLQQVALQQQQQQQQQQFQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQQQQQQQQQVMQAQPPIQQPPMQQLQPPPSQALPQQLPQLHHPQHHQPPPQTQQPQVAQNQPPQLPPQSQSQPLVSQAQALPGQMLYTAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQPTAVQTAQAAQMVAPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAQSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPMVCSRKRKLEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICRLDDKDLPTVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHQCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length663
PositionTail
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.04
Grand average of hydropathy-0.766
Instability index87.57
Isoelectric point9.15
Molecular weight74435.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11892
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.99|      25|      27|     105|     131|       2
---------------------------------------------------------------------------
  166-  191 (40.76/ 9.22)	QQ.QQQQQQVM..QAQpPIQQPPMQQLQP
  192-  219 (35.23/ 6.31)	PPsQALPQQLPqlHHP.QHHQPPPQTQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.62|      24|      26|     112|     137|       5
---------------------------------------------------------------------------
  114-  137 (48.00/15.81)	AMQQQFQAVVQQQQQQLQQQQQQQ
  142-  165 (38.62/ 6.77)	KLHHQNQQQIQQQQQQLQRMAQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.63|      23|      26|     270|     295|       6
---------------------------------------------------------------------------
  223-  248 (32.13/ 6.47)	QNQP..PQLPPQSQsQPL.VSQAQAlpGQ
  270-  295 (33.50/12.87)	QVQPqvQQVQPQVQ.QPTaVQTAQA..AQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.06|      27|      27|     438|     464|       7
---------------------------------------------------------------------------
  438-  464 (46.81/22.93)	LSKMKSLLDILTDPSKRC.PLKTLQKCE
  467-  494 (46.25/22.56)	LEKLKNDMAVPTPPPPPVlPTKQQDLCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      11|      27|     621|     631|       8
---------------------------------------------------------------------------
  621-  631 (23.73/13.73)	NPFLQSVHQ.CM
  649-  660 (19.22/ 9.72)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.51|      18|      22|     557|     574|      10
---------------------------------------------------------------------------
  557-  574 (33.39/21.56)	VARLDPKFLVNLDPSHCS
  582-  599 (33.13/21.33)	ICRLDDKDLPTVPPLELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.81|      13|      63|     311|     323|      11
---------------------------------------------------------------------------
  311-  323 (26.48/10.06)	LSSPSPGQQVQTP
  384-  396 (22.33/ 7.26)	LNTPVNPSSVMSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11892 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QVMQAQPPIQQPPMQQLQPPPSQALPQQLPQLHHPQHHQPPPQTQQPQVAQNQPPQLPPQSQSQPLVSQAQALPG
2) RAPMVVQQPQVQPQVQQVQPQVQQPTAVQTAQAAQMVAPGVQVSQSGLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAQSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
173
261
247
413










Molecular Recognition Features






MoRF SequenceStartStop




NANANA