<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11890

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMTCAIHQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQTAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRAMWLIKMTCAYYCAISEAKIKKRQPTDPNLEWTQISTRYLREQLVKISDFYHMASCTSDGPVPVSAEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPSLLAAHSPHMMMGPGTAGIGAPSPGPPGPGVIPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSSNENKSTAPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTIGRVLHTLEVLDRHCFDRTDPSNSMETLYHKVFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEALDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPSSEREKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTGPQSPAGDHMDEHCLKDRDGRMEIFSPMPGESCENVNSSLGGRMSVNGEKFMKREKPRDLIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTVLLYGVGKEREEAQHQLKKITKDLLKILNKKSTTETGVGDEGQRARKNKQEAFPTLEAVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGASFHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGNYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVANPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMLDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDPSRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLSPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSSTVSSLKNDEFTVRGLRRDGNAEDIWASSQNSKSCGKGVSIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNVQAQRLLQLICYPHGIKECAEGDSLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCVKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNSSSSSAGLSLFHPHGAGNADASSTRQTGVKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLASSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERDQADIKARQAVHEALQLRLNLVGGMFDTVQRSAQWTTDWALLFLQIITSGAVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPTPLSWAWFGTVRVDRRVIRYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKPAELPDPGKNAADEEKKTKGRKRKTKCGSRMDEYPQSNIYRAPPNYSPISSQVMHHAPPTVWGYNLVGQPPQPAFFLQNQSLTPGGSRLDPAGSIVPASTKQALSYMLQRRSGAVTQPLTLHGLTSQQQFIQMKLLQQQQQHRLLRQAQTRPFQQAQPGDPAALFAAQARPSPQPPQYPGLQQAQTMPQGYTMYGTQTPLQPTVQPQAGGAVLSPGYNGRAHPAAHSSPVLVDRLRQMQPQPGGYVQRQAPQYLQTLASAQRLTHQALPQSPLVGTGVSAVLTSAPPALPSVPPPQDPGRPGQPPARPQQRLLQLPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGEAPYGHPSHF
Length2080
PositionKinase
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.07
Grand average of hydropathy-0.350
Instability index54.84
Isoelectric point7.50
Molecular weight230911.71
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11890
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     353.50|     100|     126|    1785|    1910|       1
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 1785- 1885 (121.58/98.88)	...........................GYNL.VG.QPP.QPAffLQNQSltpGGSRLDPA..GSIVPASTKQALsyMLQRRSGAVTQPLTLHGltsqqqFIQMklLQQQQQHR....LLRQAQ.....TRPFQQAQP.GDP.......AA
 1886- 2003 (144.51/99.18)	LFAA.QARPSPQPPQypglqqaqtmpqGYTM.YGtQTPlQPT..VQPQA...GGAVLSPGynGRAHPAAHSSPV..LVDRLRQMQPQP...GG......YVQR...QAPQYLQ....TLASAQ......RLTHQALP.QSPlvgtgvsAV
 2004- 2077 (87.42/46.32)	LTSApPALPSVPPPQ................dPG.RPG.QPP..........................ARPQ......QR....LLQ.LPRQG............LQQTQQQQqtaaLVRQLQkqlssNQPQQGEAPyGHP.........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.74|      40|     133|      90|     143|       2
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  100-  143 (62.77/83.57)	LAILAKKVPIlskKEDVFAYL....AKYSVPMVRAMWLIKmTCAYYCA
  230-  273 (63.96/42.21)	LDVLEKIRPM...DDDLLKLLlplmLQYSDEFVQSAYLSR.RLAYFCA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.61|      15|     140|     172|     190|       3
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  172-  190 (20.84/26.00)	QLVkISDFYhmaSCTSDGP
  319-  333 (30.77/19.12)	QLA.FSDFL...SCAQHGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.29|      34|     133|     345|     393|       4
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  359-  393 (53.69/24.03)	SNENKSTAPGSPLDLLQvAPSSLPMPGGNTAFNQQ
  494-  527 (53.60/20.27)	SGKHRAMAVAKLLEKRQ.AEIEAERCGESEALDEK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     437.42|     114|     134|     802|     919|       5
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  802-  919 (182.29/142.29)	QL.IFDLMEPA.LNINGLIDFAIQLLNELSV..VEAELLLK.SSSLAGN...........................YTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGL...CGvvKHVANPSECSSPERCILAYLYDLY..VSCSHLrsKFGD
  930- 1053 (122.99/84.94)	QT.IYNNVMPAnSNLRWDPDFMLDFIENPSArsINYSVLGKiLSDNAANrysfvcntlmnvcmghqdpsrindianFSSELTAC..........CTVLSSEWLG.VLKAL...C...........CSSNH..VWGF.NDVLctVDVSDL..SFHD
 1054- 1151 (132.15/91.35)	SLaTFIAILIA.RQCFSLED.VVQHVALPSL..LAAA.CGD.ADAEPGA...........................RMT..CRLLLHLFRAPQAC..LSPQATGKPFPGIrssCD..RHLLAAAHNSIEVGAVFAVL..................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.37|      76|     126|     547|     632|       6
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  547-  632 (121.52/96.12)	LLRFLD..TQAPSLSDPSSEREKVEfvNLVLLFC.....EFIRHDVFShdaymctlISRGDLSVTGPQSPAGDHMDEHCLKDRDGRMEIFSPM
  672-  754 (117.85/71.41)	LLRHLQyaTHFPIPLDESSSHECNQ..RTVLLYGvgkerEEAQHQLKK........ITKDLLKILNKKSTTETGVGDEGQRARKNKQEAFPTL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.09|      27|     155|    1560|    1586|       7
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 1560- 1586 (47.20/30.52)	SPGGSE.ENKRAYM.....NLVKKLKKELGDKR
 1713- 1745 (35.89/21.38)	SPVSQEpERKPAELpdpgkNAADEEKKTKGRKR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.14|      33|     126|    1463|    1518|       8
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 1247- 1293 (49.59/29.02)	DPVLSNVQAQRllqlicyphgikecAEGDSLQRQHIKRILQ...NL........E...QWT
 1466- 1512 (42.55/75.42)	NQILSNWREER..............DQADIKARQAVHEALQlrlNLvggmfdtvQrsaQWT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.94|      15|      38|    1588|    1602|       9
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 1588- 1602 (26.83/17.21)	ESIDKVQQLLPLPKQ
 1627- 1641 (26.11/16.51)	DSIDKKQGLQVSTKQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.41|      38|     149|    1163|    1205|      12
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 1163- 1205 (57.85/54.67)	GSSTVSSLKN..DEFTVRGLRRDGNAEDIwassqNSKSCGKGVSI
 1313- 1352 (56.56/39.60)	GSGSVAEMNNllDNIAKATIEVFQQSADL.....NSSSSSAGLSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11890 with Med12 domain of Kingdom Metazoa
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