<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11885

Description mediator of RNA polymerase II transcription subunit 26 isoform X2
SequenceMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTQNEELAKRAKRLLRSWQKLIEPAHAHQNEAALRGLPGLPGSANGGAHNCRPEAGTAGAPKSILDLKTRNDIQRLPGQRLDRLGGRKRRGDQRNLGHPGPPPKVAKAGHESQVPNSSPLPTNGLSGSPESLPSPRDSSGRLEPSENDKHGGKIPINAVRPHPTSPGPGQPLGPCPQTKASVLQQLDRVEETPGPPHPRGPPRCSFSPRNSRHEGSFARQRSPCAPKGSVPSPSSRHQPLDTPQVPSPLPPAQPSTPPVRRLELLPSAESPGRWPEQPEGHPRLAGPGCKAGPLPAEPLLARAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQEAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPLRVDSPVQAEPPARTEPDKSEAKASLQSPFEQTNWKELSRSEIVQSYLSRQSSLLSSSGAQTPGAHHFMAEYLRQEESSRRGTRQPHVLLPLEPPSHLPGLTREIARDDLDRLQAGRWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNVLPYVCLD
Length568
PositionUnknown
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.03
Grand average of hydropathy-0.929
Instability index65.02
Isoelectric point9.54
Molecular weight61843.74
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11885
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     508.69|      90|      91|     112|     201|       1
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   44-  113 (72.43/18.04)	KRAKRL............LRS..WQK.LI.EP....................................AHA.HQ..NEAAL...R..GLPG....LPGSAN.................GG...AHN..CRP.EA.GT.AgapksildlktrndiqrlPG
  114-  204 (163.19/49.32)	QRLDRLGGRK........RRG..DQRNLG.HP......................GPP.....PKVAKAGHE.SQVPNSSPL.PTN..GLSGSPESLPSPRDS....SGRLEPSENDKHGGKIPINA..VRP.HP.TS.P.................gPG
  205-  294 (103.03/28.59)	QPLGPCPQTKasvlqqldRVE..ETPGPP.HP.....................rGPPrcsfsPRNSR..HEgSFARQRSPC.APK..G......SVPSPSSR....HQPLDTP.......QVP.SP..LPPaQP.ST.P..................PV
  295-  376 (88.46/23.56)	RRLELLPSAE........SPGrwPEQPEG.HP...................rlaGPG........CKAG....PLPAEPLL.ARA..GLS..PDS..SKADSdaasSG...GSDSKKKKRY........RP.RDyTV.N.................lDG
  377-  510 (81.59/21.20)	QEAE.AGVKP........VRL..KERKLTfDPmtrqikpltqkeplrvdspvqaEPP.....ARTEPDKSE.AKASLQSPFeQTNwkELSRS.EIVQSYLSR....QSSLLSSSGAQTPGAHHFMAeyLRQ.EE.SSrR.gtrqphvllpleppshlPG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11885 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAHHFMAEYLRQEESSRRGTRQPHVLLPLEPPSHLPGLTREIA
2) PAHAHQNEAALRGLPGLPGSANGGAHNCRPEAGTAGAPKSILDLKTRNDIQRLPGQRLDRLGGRKRRGDQRNLGHPGPPPKVAKAGHESQVPNSSPLPTNGLSGSPESLPSPRDSSGRLEPSENDKHGGKIPINAVRPHPTSPGPGQPLGPCPQTKASVLQQLDRVEETPGPPHPRGPPRCSFSPRNSRHEGSFARQRSPCAPKGSVPSPSSRHQPLDTPQVPSPLPPAQPSTPPVRRLELLPSAESPGRWPEQPEGHPRLAGPGCKAGPLPAEPLLARAGLSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQEAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPLRVDSPVQAEPPARTEPDKSEAKASLQSPFEQTNW
474
59
516
445










Molecular Recognition Features






MoRF SequenceStartStop




1) RRLELL
2) SKKKKRYRPRDYTVNLDGQEA
3) VRLKERKL
295
359
386
300
379
393