<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11883

Description mediator of RNA polymerase II transcription subunit 25 isoform X2
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIRFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPADVSQDPRHMVLVRGLVLPVGGSSAAGPLQPKQPVPLPPAPSSAATLSTAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPASTLPQGPPGAPKPPPSSQPSLVSTVAPGPGLAPPAPSGAASMAGSVAPGGVSGPSPAQMGAPALGGQQSVPNKLLAWSGVLEWQEKPKPASVDASTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFNKDQESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPPQNLLQLRAPQPQPQATVGASGAAGQPQPQSTTQAPPGAPQGPPGAAPGPPPPGPTLRPQNPGANPQLRSLLLNPPPPQSGVPLPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length745
PositionUnknown
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.05
Grand average of hydropathy-0.230
Instability index62.20
Isoelectric point8.61
Molecular weight77929.47
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11883
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.45|      38|      38|     585|     622|       2
---------------------------------------------------------------------------
  241-  284 (43.40/ 6.69)	PKQPVPLPP.APSSaatlstaPQQA..lPPVP..PQYQVPGNLSAAQV..A
  577-  604 (51.59/ 9.40)	PQNLLQ.................LR...APQP.QPQATVGASGAAGQP..Q
  605-  630 (56.92/11.17)	PQSTTQAPPGAPQG.......PPGA...APGP.PP............P..G
  689-  732 (44.54/ 7.06)	LGPPLLHPPPAQSW.......PAQLpprAPLPgQMLLSGGPRGPVPQPglQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.53|      17|      18|     338|     355|       4
---------------------------------------------------------------------------
  338-  355 (28.30/11.46)	PPPSSQPSLVSTVAPGpG
  359-  375 (29.22/ 8.14)	PAPSGAASMAGSVAPG.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.92|      30|     111|      39|      69|       5
---------------------------------------------------------------------------
   39-   69 (53.43/34.55)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  151-  183 (44.49/23.77)	YLLPAVESTTySGCTTES.LVQKIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.87|      54|      73|     428|     485|       6
---------------------------------------------------------------------------
  393-  427 (41.72/18.71)	.......................QSVP..........NKLLAWSGVLEWQEKPKPASVDASTKLT...RSL
  428-  485 (85.62/61.64)	PCQVYVNHgeNLKTEQwpQKLIMQLIP..........QQLLTTLGPLFRNSRMVQFHFNKDQESL...KGL
  504-  557 (57.53/30.17)	PCEVRVLM..LLYSSK..KKIFMGLIPydqsgfvngiRQVIT.......NHKQVQ......QQKLeqqRGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.15|      12|      88|     563|     574|       7
---------------------------------------------------------------------------
  200-  211 (22.52/ 6.47)	PPALLEPLQPPA
  563-  574 (22.20/ 6.24)	PPGLGPILEDQA
  653-  663 (22.43/ 6.40)	PPQSGVPL.PQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11883 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAPSSAATLSTAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQAPASTLPQGPPGAPKPPPSSQPSLVSTVAPGPGLAPPAPSGAASMAGSVAPGGVSGPSPAQMGAPALGGQQ
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPPQNLLQLRAPQPQPQATVGASGAAGQPQPQSTTQAPPGAPQGPPGAAPGPPPPGPTLRPQNPGANPQLRSLLLNPPPPQSGVPLPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDI
237
543
393
740










Molecular Recognition Features






MoRF SequenceStartStop




NANANA