<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11877

Description mediator of RNA polymerase II transcription subunit 23 isoform X3
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLSAFRQFWNGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGVLPPRIVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMKIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTDQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLDRIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVNDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMYLRKRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSNSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEYQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKLEPAAVPQPAVNSGSPAPQSTQVPAPLPVTQ
Length1367
PositionTail
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.10
Grand average of hydropathy-0.010
Instability index45.32
Isoelectric point6.98
Molecular weight156242.87
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11877
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.51|      34|      81|     377|     411|       1
---------------------------------------------------------------------------
  377-  411 (56.13/42.07)	QFISGSIQKNAL..ADFlPVMKLFDLLYPEKECIPVP
  455-  490 (53.38/35.07)	EFLQQSLRNKSLqmNDY.KIALLCNAYSTNSECFTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.50|      46|     262|     970|    1015|       2
---------------------------------------------------------------------------
  970- 1015 (85.05/59.85)	IHRFLE..LLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMYL
 1226- 1278 (64.45/43.32)	IPKFLTevLLPIVKTEYQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.63|      19|     127|     904|     922|       3
---------------------------------------------------------------------------
  904-  922 (40.44/25.37)	KENSPEHWLQNDWHTKH.MN
 1034- 1053 (34.19/20.26)	KDNRPQGWCLSDTYLKNaMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     343.84|     112|     867|     192|     355|       4
---------------------------------------------------------------------------
  197-  321 (165.17/226.52)	PH.WlLGNLVSDFVDTFRPTARINSICGRcSLLPVVNNSGAICNSWK....LDPATLRFPLKGLLPydkdLFepQTALLRYVLEQpysrDMVcNMLG...LNKQKQRCPVLE.DQLVDLVVYAMERSETEEKFD
  723-  843 (178.67/112.86)	PHnW.ASHTLSCFPAPLQAFFKQNNVPQE.SRFNLKKNVEEEYRKWKsmtnENDIITQFSVQGFPP....LF..LCLLWKMLLET....DHI.SQIGyrvLDRIGARALVAHvRTFADFLVYEFSTSAGGQQLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.81|      69|      81|     515|     592|       5
---------------------------------------------------------------------------
  499-  578 (81.49/89.16)	YGNGIMKIPLPgtSCLASGSITPLpMNLLDSLTVhaKMSLIHSiATRVIKLAHTKSsvaLApALVETYSRLLvYMEIESL
  579-  647 (122.32/86.21)	GIKGFISQLLP..TVFKSHAWGIL.HTLLEMFSY..RMHHIQP.HYRVQLLSHLHT...LA.AVAQTDQNQL.HLCVEST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.63|      35|     301|     846|     883|       8
---------------------------------------------------------------------------
  846-  883 (58.13/51.46)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCY.F
 1152- 1187 (58.51/42.06)	ITALPEPYW...IVLHDRIVSVISSNSLTSETEWVGYpF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11877 with Med23 domain of Kingdom Metazoa
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