<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11874

Description mediator of RNA polymerase II transcription subunit 23 isoform X1
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLSAFRQFWNGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGVLPPRIVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQQKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMKIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTDQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLDRIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVNDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMYLRKRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSNSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEYQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKLEPAAVPQPAVNSGSPAPQSTQVPAPLPVTQ
Length1374
PositionTail
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.10
Grand average of hydropathy-0.010
Instability index45.60
Isoelectric point6.98
Molecular weight157011.73
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11874
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     391.47|      83|     216|     171|     253|       1
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  171-  253 (141.64/75.48)	LERNACLLPAY.FAVTEIRK.LYPEGK.LPHWLLGNLVSDFVDTFRP.TARINSICGRC.SLLPVVNNSG.....AICNSWKLDPATLRF.PLK
  254-  300 (43.60/18.47)	..................................GLLPYD.KDLFEPqTALLRYVLEQ.....PY..SRD.....MVCNMLGLNKQTLNIaQQK
  306-  385 (104.23/53.72)	LEDQLVDLVVYaMERSETEE.KFDDGG.TSQLLWQHLSSQLI..FFV.LFQFASFPHMVlSLHQKLAGRG.....LIKGRDHLMWVLLQF....
  390-  469 (102.01/52.44)	IQKNA..LADF.LPVMKLFDlLYPEKEcIP.......VPD.INKPQS.THAFAMTCIWI.HLNRKAQNGDsnlqiPIPHSLKLHHEFLQQ.SLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.81|      69|      81|     522|     599|       2
---------------------------------------------------------------------------
  506-  585 (81.49/86.89)	YGNGIMKIPLPgtSCLASGSITPLpMNLLDSLTVhaKMSLIHSiATRVIKLAHTKSsvaLApALVETYSRLLvYMEIESL
  586-  654 (122.32/84.03)	GIKGFISQLLP..TVFKSHAWGIL.HTLLEMFSY..RMHHIQP.HYRVQLLSHLHT...LA.AVAQTDQNQL.HLCVEST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.63|      35|     301|     853|     890|       3
---------------------------------------------------------------------------
  853-  890 (58.13/44.64)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCY.F
 1159- 1194 (58.51/36.47)	ITALPEPYW...IVLHDRIVSVISSNSLTSETEWVGYpF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.50|      46|     257|     977|    1022|       4
---------------------------------------------------------------------------
  977- 1022 (85.05/58.97)	IHRFLE..LLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMYL
 1233- 1285 (64.45/42.71)	IPKFLTevLLPIVKTEYQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.35|      28|     698|      29|      56|       5
---------------------------------------------------------------------------
   29-   56 (51.89/28.97)	TPEDEKTKLISCLSA.FRQFW..NGLSQESH
  729-  759 (45.46/24.54)	TPHNWASHTLSCFPApLQAFFkqNNVPQESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.72|      40|     365|     920|     970|       6
---------------------------------------------------------------------------
  922-  970 (67.95/73.73)	DWHTKHMN.........YHKKYpeklYFEG..LAEQVDPPVQIQSPYLPIYfgnvcLRFL
 1288- 1338 (62.76/38.36)	DQCSTHLNymdpicdflYHMKY....MFTGdsVKEQVEKIICNLKPALKLR.....LRFI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11874 with Med23 domain of Kingdom Metazoa
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