<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11873

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQSLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGKKIGIASVHKVIIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKVKDLNIFXFXIPALITKAEQXLKVLKCIAAGFGSLDSTSIETALPAIVVPILEPCSNSECLHIFVDLHSGMFQFMLYGLDQATLDDMEKSVNDDIKRIIPWIQQLKFWLGKQRCKQSIKHLPTISTETLQLSNYSTHPIGKLSKNKLFIKLTRLPQYYIVVELLEVPNEPTQLSYKYYFMSVNTADREDGPVMALLLQQFKENVQDLVLRTKPGKPTKTGTKRKLSDDSCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRCLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSSRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVTDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismDipodomys ordii (Ord's kangaroo rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys.
Aromaticity0.07
Grand average of hydropathy-0.144
Instability index51.20
Isoelectric point8.94
Molecular weight160057.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11873
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     224.83|      32|      32|    1036|    1067|       1
---------------------------------------------------------------------------
   11-   35 (43.55/20.56)	L...VP.................PGGGGGGSGGP..A....SAPAPP..P..PGA
 1028- 1064 (46.26/22.40)	YhstVN...............qsPSMMHTQSPGN..LHA.ASSPSGALRAPSPAS
 1065- 1098 (47.08/22.96)	F...VP...............tpPPSSHGISIGP..GAS.FASPHGTLDPSSPYT
 1099- 1123 (34.59/14.48)	M...VS.................PSSRAGNWPGS...PQ.VSGPSPATR......
 1125- 1152 (22.94/ 6.56)	.......................PGM....SPANpsLHSpVTDASHSPRAGTSSQ
 1153- 1201 (30.40/11.63)	T...MPtnmppprklpqrswaasIPTILTHSALN..ILL.LPSPTPGLVPGLAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.84|      32|      32|     272|     303|       2
---------------------------------------------------------------------------
  246-  268 (21.51/10.74)	....RLLKLEILVEDKETGDGRAL..VHS......
  272-  303 (56.97/42.51)	NFIHQLVQSRLFADEKPLQDMYNC..LHS.FCLSL
  306-  337 (40.37/27.64)	EVLHS..QSLMLIRER.WGDLVQVerYHAgKCLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1363|    1386|       3
---------------------------------------------------------------------------
 1362- 1385 (39.65/18.78)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1386- 1411 (34.41/15.35)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.38|      30|      30|     116|     145|       4
---------------------------------------------------------------------------
   85-  112 (23.24/10.52)	..IVQFASRTRQ..LFV....RLLALvkwANDAgKV
  116-  145 (48.83/30.48)	AMISSFLDQQAI..LFVDTADRLASL...ARDA.LV
  147-  178 (46.31/28.52)	ARLPSFAIPYAIdvLTTGSYPRLPTC...IRDK.II
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.04|      35|      54|     744|     781|       5
---------------------------------------------------------------------------
  744-  781 (50.19/50.15)	HVYlTYENLLsEPVGGRKVVEMFLnDWNSIARLYECVL
  801-  835 (63.85/46.23)	RVY.NYRKLI.LCYGTTKGSSISI.QWNSIHQKFHISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.27|      11|      24|     704|     714|       6
---------------------------------------------------------------------------
  704-  714 (22.93/14.27)	CLLDCT.FRLQG
  729-  740 (18.34/ 9.83)	CPLNGTsTREQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1247|    1261|       7
---------------------------------------------------------------------------
 1247- 1261 (21.47/16.65)	LKCRVALSP.KTNqTL
 1285- 1299 (22.14/11.72)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.80|      14|      30|     500|     513|       8
---------------------------------------------------------------------------
  500-  513 (27.01/20.32)	LGK.QRCKQSIK..HLP
  530-  546 (15.79/ 8.34)	IGKlSKNKLFIKltRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.03|      34|     508|     346|     379|       9
---------------------------------------------------------------------------
  346-  379 (59.84/38.15)	GKKIGIASVHKVII.KIDE..N...DVSKPLQIFHDPPLP
  839-  878 (47.19/28.49)	GPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11873 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSSRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVTDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLENHQLVPPGGGGGGSGGPASAPAPPPP
970
4
1170
33










Molecular Recognition Features






MoRF SequenceStartStop




1) FLLEPPGHNKENEDDVEVMSTDSS
196
219