Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADVAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGTGTILAGASGLQQVQMAGAPSQQQPMLSGVQMAQASQPGKMPSGIKTNIKSASMHPYQR |
Length | 179 |
Position | Head |
Organism | Dipodomys ordii (Ord's kangaroo rat) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Castorimorpha> Heteromyidae> Dipodomyinae> Dipodomys. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.698 |
Instability index | 59.17 |
Isoelectric point | 9.13 |
Molecular weight | 19056.23 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11859 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.58| 21| 42| 102| 129| 1 --------------------------------------------------------------------------- 102- 129 (26.11/24.36) LSNWRPSGSsgPGQPgQPgtgtILAGAS 131- 151 (35.48/13.97) LQQVQMAGA..PSQQ.QP....MLSGVQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GKMPSGIKTNIKSASMHPYQR 2) KQTFNPADTNALVAAVAFGKGLSNW 3) LQQVQMAG | 159 81 131 | 179 105 138 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab