<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11831

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMATAELGQQTVELSTLVTRTAQDSYNSLKELVDKCRSIELSDTDKKISMLKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLSGSYQRLPKCIEDVGSQYALTEDKQKPALNKLDTLVRSKLLEVSLPKEISDIQVSDGTAMVRVDGEFQVLLTLGYRGHMSLWRILHLELLVGEKNKPVKLEELRRHVLGDDLERRMAATENPFSILYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELITEGGSGHGASSSSLQNPDGESDSSGLRTPGLKIVYWLDFDKNAGMSDSGVCPFIKVEPGSDLQIKCTHSNFVIDPLTGKEAEFFLDQNCIDVEGLLLMAIRCNRYTRLLEIKRELIKNVQVCRTADDVVLQSRMGEPDIEHKQKDDKCCNKELDGHEVLRVRAYGSSFCTLGISIRNGRFLLQSSQNIVVSSALLECEEALNQGSMTAAEVFLSLRSKSILHLFASIGRVLGLEVYEHGLNTVKIPKTFLNSSAMLMMGFPDCGSSYFLLMQLDKDFKPLFKLLETHPDPSGKDNLFGDLNQVLRFKKIDIAQMQVLEDEMNLSLVDWGKLRTILPNVSCSNQILGHELYSDTGLESSIHISRGHHPSGFSSLVDEVFGLEIGSSVPPFPIQNLASPSNTSLPSHYGSVPMNSHSLKAGIPSPKWEGGMQISQVNNVTTLYNGSMFSSGGVKGPVQSSSVGSIPTGQGRSTVGKKLSASKSEQDLASVKSPHSVDISSSTPMDEDTANDALSGSRSSLLSPPRPTNSRLSAPSSRPNGPLVESFKAAGSSSCATTPVSQGLECTVAFGTSEDVISEHDKKSRKRTASDMLNLIPSLQGVLKNQGNCKRRKISDSCGSQLSLPPGTFSSEMIPKAEGCSYGSLIAEANKGNAPTSVYVAALLHVVRHSSLCLKHARLTSQMDALEISYVEEVGYRSASSNIWFRLPFARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSSNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEEDSIKKLVADIQRLANARTFSIGMRKLLGTRADERSEELITSSDAKISGAKTASDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESSKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAAPFPKQAGYISSQGLLLGSSTANVGQPASGSGANTVMSNASGITNQTLSMLAAAGRGGPGIVPSSLLPFDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLTNSNNPNPNSGAQLMAANGNRLNSAAMSRTGNQAASLNRMGNALAGSSNLALMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPIPEELSPSEISEICDYFSRRVASEPYDASRVASFITMLTLPIPVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHAGLNGDENSESSSAFRSNIHYDRLHNSVDFALTIVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESLNVSFLGMNGSHGGRACWSRVDDWEKCKQRVARTVEVNASSAADVSQGRLKLVADSVQRNLQMCIQGLRDGSGVTASSGAT
Length1799
PositionTail
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index44.79
Isoelectric point7.01
Molecular weight195882.86
Publications
PubMed=26259924

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11831
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      13|      17|    1392|    1406|       1
---------------------------------------------------------------------------
 1392- 1406 (18.60/16.08)	GAQlmAANGNRLNSA
 1412- 1424 (24.23/13.55)	GNQ..AASLNRMGNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     596.87|     118|     259|     608|     725|       2
---------------------------------------------------------------------------
  498-  605 (134.46/80.37)	EVFLSL....RSKSILHLF.ASIGRVLGLEVY.EH.GL.NTVKI.....PKTFlnsSA.ML..MMGFpDCGSSY...FLLMQLDkdfKPLFKLLETHPD..PSGKDNLFGDLNQVLRFKKI...............DIAQMQVL
  608-  725 (200.30/124.12)	EMNLSLVDWGKLRTILPNV.SCSNQILGHELYSDT.GLESSIHISRGHHPSGF...SS.LVDEVFGL.EIGSSVP.PFPIQNLA...SPSNTSLPSHYGSVPMNSHSLKAGIPSPKWEGGM...............QISQVNNV
  728-  847 (127.38/75.67)	LYNGSMFSSGGVKGPVQSS.SVGSIPTG.QGRSTV.GKK....LSASKSEQDL...AS..VKSPHSV.DISSSTPmDEDTANDA..lSGSRSSLLS..PPRPTNSR.LSA..PSSRPNGPLvesfkaagssscattPVSQ....
  876-  979 (134.73/80.55)	DM.LNLIP..SLQGVLKNQgNCKRRKI.....SDScGSQLSL......PPGTF...SSeMIPKAEGC.SYGSLIA.EANKGN.....APTSVYVAALLHVVRHSSLCLKHARLTSQMD.AL...............EISYVEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.99|      33|     259|    1349|    1387|       3
---------------------------------------------------------------------------
 1349- 1387 (48.83/43.14)	LPCPQFRPFiMEHVAQElNGLDPSftgqQAGGLTNSNNP
 1609- 1641 (57.16/31.43)	LPIPVLREF.LKLIAWK.KGLSQA....QVGDVVSAQKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.70|      16|     260|    1452|    1471|       4
---------------------------------------------------------------------------
 1433- 1448 (26.80/17.64)	LMTSAVSLRRPPGTVV
 1456- 1471 (27.90/11.68)	LNTAIIGLGDDGGYGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.20|      24|     118|    1203|    1227|       7
---------------------------------------------------------------------------
 1203- 1227 (38.51/25.69)	IRLTAGPLHALAAATrPARAGPVPG
 1323- 1346 (47.69/27.84)	MRCFAGDQVWLQPAT.PPKEGRLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.53|      10|     400|    1297|    1306|       8
---------------------------------------------------------------------------
 1297- 1306 (18.95/10.30)	LPFDVSVVLR
 1703- 1712 (20.58/11.80)	LPYCVSVRLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11831 with Med14 domain of Kingdom Viridiplantae
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