<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11829

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMRRYHAGSCTSAVNNSTISGPSARDSGRIDSSSLPTNFPVSSRRQPSLNSYKLKCDKEPLNSRLGPPDFNPQTPNCPEETLTREYLQSGYRDTVEGLEEAREILLTQIPHFNKTIVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLSKPGVFPEQRPCPEDFRKKWIEGLSQQHRRLCSLDDLVPQCRRKSVLDVLIRNNVPLLRATWFVKVTYLNLVRPGSASVPSGTNDKTQLSCSELWTKDIIEYMQTLLDDFFSKNTSQSTPHNRDQSPQMSYATSLKHRSSQLLPVSDGEEPSLHFRWWYVVRLLQWHHTEGLLLPSLVIDWIFHQLQEKQLLEIWQLFLPIVYGFLEIVVLSQTYVRTLAGVALSIIRDPAPGGSDLVDNSRRAYTAAALIEMLQYLIFAVPETFVTLDCFPLPFSVVSHTINDGNFVPKAIEAAEKIKNSSEDVVCTFRSKGLDAKYESLAFGRVISCIQKHAENLTKAVSPGYPGHCLAKAAQALDKSLVLGDIRGAYTFLFEDLYDGRSSEGWVAKISPCLRLSLKWFVNVNSSLVYSVFFLCEWATSDFRDFRTAPPCDIKFTGKKDLSQVHIAVRLLKMKLRNMHISSRQRNENTHHGVDYSAKCSSQHINWNNASKIKSSSKSMNQSICSSVIFESPGPLHDIIVCWIDQHVVHKGVGFKCLHLFIVELILAGIFYPLAYVRQLIVSGIMDTSVNMVELERQKRHCQILKQLSGNFVRHALEESEIIEGPLLIEALHVYLNERRLILRGSFSENHINGSSRANNSTVNKKHCTSSAKDGFSTVSIDQQKTVPSNKISDKVEKDNTCVENLKTAISVLLQLPKSLPNPNTTELGESQGSVKRLVRCYSKIDLMEATPGCEECRRAKKQKLSEERSSLDVEDTWWVKKGLKSLEPLKVDQPLKTTKQVTKSRHKTVRKTQSLAQLAASRIEGSQGASTSHVCDIKVSCPHHRTAMDGDTAKSVDGIRTSQYQDIVSLGRALKRLRFVEKKEITVWLMTVIRQFIGDSEKSIGKVGQFGRPVTTMDDRSSIRWKLEEDELSAILYLMDVSDDLVPAIKFLLWLLPKVCSSSNSTIHSGRNVLMLARNVDNQVCNVGEAFLLSSLRRYENILASADLIPEALSSVMDRAAAIIASNGRVSGSGALAFARYLLKKYSNVVSVIEWEKNFKTTCDKRLASEFESGGRLVDGEFGLPLGVPAGIEDPDDYFRQKISGGRLPSRVASGMRDVVQRNVEDAFHYLFGKDRKLFAAGSPKGFSLEKWDNGYQIAQHIVIGLIDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPSLAKLPDFSAGNNHPNISLATSSLNYAKCILRMHITCLCLLKEALGERQSCVFDIALAIEASNALAGVFAPSKASRSQFQMSPETDDTSATMSNDVVNSSSKIVLARTTKIASSVSALIVGAIIYGVTSLERMVTILRLKEGLDVVQFVRNSRSNSNGNARSTGAIKVDSSVEVHLHWFRLLVGNCRTICEGLVVDLLSEPSIVAFSRMQRTLPQRLVFPPAYSIFSFVIWRPFITSANVANREDTNQLYQTLTMAINDAMKHLPFRDVCLRDSQGLYDLIAADTSDLEFANLLELNGSDMRLNSTAFVPLCARLFLNAMVDCKMPQSIYTKDGGSCISGHGESKIHFTDSESKLQDQLVDVLEALQPAKFHWQWVELRLLLNELALIEKLQTHNVSLADAIQLSLPSSEKAAASENENNFIQILFTRLLVRPDAAPLFSELVHLFGKSLEDSMLLQAKWFLGGEDVLFGRKTIRQRLINIAETKGFSVKPHSLEPWGWCSPSTDPLTIKGGKRKVDSLSLEEGEVVEEGVNVKRSIKGFSQVFDSEGSTIKQQHGTERAFLELILPCIDQSSNESRYSFASGLIKQLSYIEQQIAVVTCGPGNPAASMPVTEGQTNKGNSRKTIKGGSLGLARRPTSSTDSSPPSPAALRASMSLRIQLLMRFLPILCTDGEPSVRNMRRTLASVTLRLLGSRIVLEDANILVNATHSSLSKKDAESPSKVAYAAFVDSSVEGLFERLLLMLHGLLSSSPPSWLRLKPVSKTTTNEPTRDLSGVDRELLETLQNHLDNMQLPDSIRWRIQAAMPLLPPSTRCSFSCQPPFVPNSSLVSLQPNITNSGFNYSSVAIPQRSPVPLSRTAASGKSKQQDDDFEVDPWTLLEDGAGSCPSASNVGNGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2258
PositionKinase
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.07
Grand average of hydropathy-0.203
Instability index50.30
Isoelectric point8.73
Molecular weight250257.33
Publications
PubMed=26259924

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11829
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.28|      44|     232|    1091|    1161|       1
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 1116- 1161 (70.64/91.40)	NQVCNVGEAflLSSLRRYENIL....ASADLIPEAL....SSVMDRAAAIIASN
 1344- 1395 (67.64/34.13)	NNHPNISLA..TSSLNYAKCILrmhiTCLCLLKEALgerqSCVFDIALAIEASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.49|      26|     694|     700|     725|       4
---------------------------------------------------------------------------
  700-  725 (47.44/34.45)	LAGIFYPLAYVR.QLIVSG.IMDTSVNM
 1397- 1424 (39.04/26.80)	LAGVFAPSKASRsQFQMSPeTDDTSATM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.37|      39|     196|     432|     486|       6
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  432-  486 (58.05/69.08)	SHTINDGNfvpkaieaAEKIKNSSEDV...VCT...FRSKGldakyeslAFGRVISC.IQKH
  635-  680 (61.31/38.81)	SQHINWNN........ASKIKSSSKSMnqsICSsviFESPG........PLHDIIVCwIDQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.69|      96|     380|    1632|    1741|       7
---------------------------------------------------------------------------
 1632- 1741 (144.35/124.88)	DMR..LNSTAFVPLCARLFL...NAMVDCKMpQSIYTKDGGScisghgESKI...HFTDSESK.LQDQLVDVLEALQPAKfHWQWVEL....RLLLNE....LA.....LIEKLQTHnvslADAIQlsLPSS
 2010- 2127 (126.34/76.75)	NMRrtLASVTLRLLGSRIVLedaNILVNATH.SSLSKKDAES......PSKVayaAFVDSSVEgLFERLLLMLHGLLSSS.PPSWLRLkpvsKTTTNEptrdLSgvdreLLETLQNH....LDNMQ..LPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.47|      52|     383|    1463|    1518|       9
---------------------------------------------------------------------------
 1463- 1518 (80.48/63.89)	ERMVTILRLKEGlDVVQFVRNSRSNSNGNAR...STGA.IKVDSSVEvhlHWFRLLVGNC
 1845- 1900 (77.99/49.73)	KRKVDSLSLEEG.EVVEEGVNVKRSIKGFSQvfdSEGStIKQQHGTE...RAFLELILPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.92|      37|     693|     528|     605|      12
---------------------------------------------------------------------------
  532-  571 (61.03/95.55)	DGRSSEGWvaKISPCLRLSLKWFVNVNSSLVYSVFFLCeW
 1052- 1088 (64.89/21.36)	DDRSSIRW..KLEEDELSAILYLMDVSDDLVPAIKFLL.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.05|      37|    1680|      95|     134|      17
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   95-  134 (57.18/55.42)	EGLEEAreiLLTQIPHF.NKTIVLNCKEAIRKRLRAINESR
 1780- 1817 (58.88/47.12)	KSLEDS...MLLQAKWFlGGEDVLFGRKTIRQRLINIAETK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11829 with Med12 domain of Kingdom Viridiplantae
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