<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11820

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMLKFLKEQLTKLQEYYQHSSSSSVITEEQKIALKQWQYCTQLTKYMYQEGLIERQELLQWIIDLLEKLKSFSTDDGILKLILPIALQYLDEFVQSELMSRRLAYLCSKKLSQLSNNSEQSGASNSILSPHSPAVNNNTSSNSITSSGNPNSTGPPGTNTTANNSSAGNNTAANSNNSNNNTSSALVPTNTTQSLFSEYMSCGHHRDIVLSLSAIIQAITLECPTALVWNCIGEGKSPSVLNGSPLDHLPCSPAQLPMPQRSSNSHLKSQLKWGEDLIRQRSLAAEGRWSCDKWHQTSSGQTINKILGVLDALDRHAFERVDANNSLDTLYSKVFLPPGTKENAQNQQPSEEVANKNDYTVQQDEAVVHILCEWAVSGLRFGEHRAIAVAKLLEKRQNEVTAGSSSNDTEPGDDKDSVSSMPAGLPVFQPLLMKFLDQDAPTDENKTTFTNLVHLFAELIRHEVFSHDAYMCTLISRGDLPSTGGNTTSTHPASNKPADTPMDEFDLKPPTKIEPQEHRGGHMDDDSKIDDDLDKLLQHIKEEQQNSMDAPDSPKDVTGSLVGGIVLHGEQHQTQESGDKTKQSRHQLYTKHFPIPQDESYYHDCNQRLVLLYGVGRERDNARHNVKKMTKELCKLFTKKFSIDVADGGKVKKHSRSEFNFDQQHLSFFDQHYMTWQCSLTVLEMIQSFALGNSNYLPVQVS
Length699
PositionKinase
OrganismDiaphorina citri (Asian citrus psyllid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Psylloidea> Liviidae> Diaphorina.
Aromaticity0.07
Grand average of hydropathy-0.616
Instability index53.61
Isoelectric point5.71
Molecular weight78213.41
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11820
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.42|      24|      30|     136|     160|       2
---------------------------------------------------------------------------
  136-  160 (41.74/28.67)	NNTSSNSITSSGNPNSTGPPgTNTT
  168-  191 (43.68/25.19)	NNTAANSNNSNNNTSSALVP.TNTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     407.16|     107|     255|     231|     337|       3
---------------------------------------------------------------------------
  231-  337 (186.46/110.05)	IGEGKSPS.VLNGSPLDHLPCS..PAQLPMP............QRSSNSHLKSQLKWGEDLIRQ.RSLA...AE.GR...WSCDKWHQTSSGQTINKILG..VLDALDRHAFERVD.ANNSLDTLYSKVFLPP
  399-  472 (67.78/35.18)	VTAGSSSNdTEPGDDKDSVSSM..PAGLPVF............QPLLMKFLDQDAPTDENKTTF.TNLVhlfAElIRhevFSHDAYMCT............................................
  474-  595 (152.92/88.89)	ISRGDLPS.TGGNTTSTH.PASnkPADTPMDefdlkpptkiepQEHRGGHMDDDSKIDDDLDKLlQHIK...EE.QQ...NSMDA.PD.SPKDVTGSLVGgiVLHGEQHQTQESGDkTKQSRHQLYTKHFPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.98|      17|      19|      57|      75|       4
---------------------------------------------------------------------------
   33-   49 (30.24/20.88)	LKQW..QYCTQLTKYMYQE
   57-   75 (22.75/21.37)	LLQWiiDLLEKLKSFSTDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11820 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQSGASNSILSPHSPAVNNNTSSNSITSSGNPNSTGPPGTNTTANNSSAGNNTAANSNNSNNNTSSALVPTN
2) SRGDLPSTGGNTTSTHPASNKPADTPMDEFDLKPPTKIEPQEHRGGHMDDDSKIDDDLDKLLQHIKEEQQNSMDAPDSPKDVTGSLVGGIVLHGEQHQTQESGDKTKQSRHQLYT
118
475
189
589










Molecular Recognition Features






MoRF SequenceStartStop




NANANA