<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11805

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMMGLGPPQGPPQGVTATNLLQTLNTRPQLQKLPPGVGQMQQGIGQVQMQGGMGPMGPGTIQGQIGGPMQNQMGGPMQNQMGGSMQNQMGGPMQNPMGGPMQNQMGGPMQNQMGGPIQNTMGGPMQNQMGSSMQNQMGGTMQNQMGGPIQNQLTNNMQSQMGGPMQNQMGGPMQNQMGGPMQNQMGGPMQSQMGGPMQNQMGGPMQNQIGGPLQNQMGGNMINQMGPQLGGPGGQMGSPLSAQMSHMVQKRPDPNMMMNAQAGFTGGPRSMNAQFIRQTPTPPQPSPVGMQHSQMVASPALVPSPSAPLSQSMPGQMRSVGMAPSPSGSLNTPGQAQPTSSPCPTQEDQVYRDKIRQLSKYIEPLRRMIARAANDDIEKTTKMKKLLEILQSPNKRMPLETLLKCEHVLEKLDFKHSSLLRDHHPLLEAVSGALQSSNANHTLQRTFGPCLEILSGPLIKDLPLPVNRKRVEEPADDVPEVLQGEIARLDQRFKVSLDPTQQSGSKAIQLVCWLDDRHLPCVPPIQVSIPEDYPSHPPRCTMGHEHNTTPFLTSVKNALESRIKKLPLKYSVSQLLDTWEMSVRQACAPTRNPTSSPDREP
Length600
PositionTail
OrganismDiaphorina citri (Asian citrus psyllid)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Sternorrhyncha> Psylloidea> Liviidae> Diaphorina.
Aromaticity0.02
Grand average of hydropathy-0.658
Instability index49.69
Isoelectric point9.14
Molecular weight64735.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11805
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     404.44|      30|      30|     156|     185|       1
---------------------------------------------------------------------------
   60-   89 (67.84/18.11)	IQGQIGGPMQNQMGGPMQNQMGGSMQNQMG
   92-  121 (72.70/19.92)	MQNPMGGPMQNQMGGPMQNQMGGPIQNTMG
  124-  153 (64.37/16.81)	MQNQMGSSMQNQMGGTMQNQMGGPIQNQLT
  156-  185 (76.40/21.30)	MQSQMGGPMQNQMGGPMQNQMGGPMQNQMG
  188-  217 (72.70/19.92)	MQSQMGGPMQNQMGGPMQNQIGGPLQNQMG
  220-  244 (50.43/11.62)	MINQM.GP...QLGGP.GGQMGSPLSAQMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.05|      40|     253|       9|      58|       2
---------------------------------------------------------------------------
    9-   54 (60.36/41.89)	GPPQGVTATNLLQTlNTRPqlQklPPGVGqMQ...................QGIGQVQMQGGMGP
  265-  323 (68.68/25.79)	GGPRSMNAQFIRQT.PTPP..Q..PSPVG.MQhsqmvaspalvpspsaplsQSMPGQMRSVGMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     291.31|      58|      70|     448|     505|       3
---------------------------------------------------------------------------
  341-  383 (65.32/33.53)	PC......PTQED...QVYRDKIRQLSKYI.......EPLRRMIAR.....A.AN..D..D..IEKTTKMK
  384-  431 (52.10/25.26)	KLLEILQSP.NKRMPL........ETLLKCE......HVLE....KLD..FKhSS..LlrDhhPLLEAVSG
  448-  505 (97.11/53.44)	PCLEILSGPLIKDLPLPVNRKRVEEPADDVP......EVLQGEIARLDQRFK.VS..L..D..PTQQSGSK
  519-  581 (76.77/40.71)	PCVPPIQVSIPEDYPSHPPRCTMGHEHNTTPfltsvkNALESRIKKLPLKYS.VSqlL..D..TWEMS...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11805 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMGLGPPQGPPQGVTATNLLQTLNTRPQLQKLPPGVGQMQQGIGQVQMQGGMGPMGPGTIQGQIGGPMQNQMGGPMQNQMGGSMQNQMGGPMQNPMGGPMQNQMGGPMQNQMGGPIQNTMGGPMQNQMGSSMQNQMGGTMQNQMGGPIQNQLTNNMQSQMGGPMQNQMGGPMQNQMGGPMQNQMGGPMQSQMGGPMQNQMGGPMQNQIGGPLQNQMGGNMINQMGPQLGGPGGQMGSPLSAQMSHMVQKRPDPNMMMNAQAGFTGGPRSMNAQFIRQTPTPPQPSPVGMQHSQMVASPALVPSPSAPLSQSMPGQMRSVGMAPSPSGSLNTPGQAQPTSSPCPTQEDQVYRDKIR
1
355










Molecular Recognition Features






MoRF SequenceStartStop




NANANA