<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11774

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAADLGQQTVEFSALVSRAAEDSFLSLKELVDKSKSSDQSDSEKKVNILKYVFKTQQRILRLYALAKWCQQVPLIQYCQQLASTLSSHDACFTQAADSLFFMHEGLQQARAPIYDVPSATEILLTGTYEHLPKCVEDISIQGTLTDDQQKSALKKLEILVRSKLLEVSLPKEISEVKVTDGTALLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERRGLVKLEQVHRHALGDDLERRMAASENPFTTLYSILHELCISLVMDTVLKQVHSLRQGRWRDAIRFDVISDGITGGSTQLNHDGETDLSGLRTPGLKIMYWLDFDKNTGSSDPGSCPFIKIEPGPDMQIKCVHSTFVIDPLTNKEAEFFLDQSCIDVEKLLLRAICCNKYTRLLEIQKELKKNVQICRTADDVVLQHQVDEPDVDPKKKDIIHDPTAFEGEEILRVRAYGSSFFTLGINTRNGRFLLQSSHNKLVTSSLTECEEALNQGSMSAADVFIRLRSRSILHLFASISRFLGLEVYENGFSAVRLPKNISNGSSMLLMGFPDCGNSYFLLMQLDKDFKPQFKLLETKPDPSGKARGLSDLSNVIRVKKIDVDQTQILEDELNLSLLDWGKLFPSLPNSAGNQTPENGLLPDISIGGALQIAGYPPSSFSSVVDEVFELEKGPPPVPSFSVSNMSQSFNSTASHYGSLSNIHNVKGVPSPKWEVGIQPSQGNNVAKLSNIPSHSNGSLYSGSNLKGPVPSTSMGSISSGPGRGAATRRLSNSKSEQDLTSLRYPNPVEGGSYTALDDDHISMPSDTSKDGVYANRSSRLLSPSPHGGPRISGSIKPNGSRSSPTAAPTGSLRPSGSCSSVSTPVSQNQDTCSSPVYESGLKNDSSRKRTASDMLNLIPSLKGIDAYNGLSKRRKVSESARFSKTSSQLLISKEMVSRTEYSYGNLIAEANKGSAPSSTYVSALLHVIRHCSLCIKHARLTSQMDALDIPFVEEVGLRNASTNIWFRLPFARDDSWQHICLRLGRPGTMCWDVKIHDQHFRDLWELQKKSTTAPWGPDVRIANTSDKDSHIRYDPEGVVLSYQSVEADSIEKLVADIRRLSNARMFAIGMRKLLGVGTDEKLEESSMTSDIKAPVTKGASDTVDKLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPVSTLPGIVATLSSLPKHGGYTPTQSVLPSSSATNTGQVTNGPVGNAVSTNVSGPLANHSLHGAAMLAAAGRGGPGIAPSSLLPIDVSVVLRGPYWIRIIYRKQFAVDMRCFAGDQVWLQPATPAKVNPSFGGSLPCPQFRPFIMEHVAQELNGLEPNFPGVQQTVGLSAPNNQNPNSSSQITAANGNRLSLPGSPAMPRTGNQVASINRVGNALSGSSNLASVSSGLPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILRDNEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSATAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGVAQAQGGDIAPAQKPRIELCLENHSGLSIDENSERSTSKSNIHYDRQHNSVDFALTVVLDPAHIPHMNAAGGAAWLPYCVSVKLRYSFGESPVVSFLGMEGSHGGRACWLRIDDWEKCKQRVARTVEVSGSSTGDVSQGRLRIVADNVQRTLHMCLQGLREGSEITTITSSTS
Length1820
PositionTail
OrganismCucumis melo (Muskmelon)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.06
Grand average of hydropathy-0.232
Instability index45.41
Isoelectric point7.71
Molecular weight198542.25
Publications
PubMed=22753475

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11774
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.01|      59|     356|     937|    1200|       1
---------------------------------------------------------------------------
  673-  731 (103.72/ 6.40)	VSNMSQSF........NSTASHYGSLSNIHNVKGVPS.....PKWEV.GIQPSQGNNVAKL.SNIPSHSNGSLY
 1024- 1097 (80.29/41.47)	VKIHDQHFrdlwelqkKSTTAPWGPDVRIANTSDKDShirydPEGVVlSYQSVEADSIEKLvADIRRLSNARMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.01|      55|     356|     167|     229|       2
---------------------------------------------------------------------------
  167-  229 (82.01/64.38)	VSLPKEISevkvtDGTALLRV...D.GE.FKVLVTL..GYRGHLSLwriLHLE.LLVGERRGLVKLEQVHR
  526-  588 (74.00/41.66)	VRLPKNIS.....NGSSMLLMgfpDcGNsYFLLMQLdkDFKPQFKL...LETKpDPSGKARGLSDLSNVIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.70|      41|     355|    1155|    1200|       3
---------------------------------------------------------------------------
 1155- 1200 (68.25/53.25)	LW.FSFGSGVLARFVVEWESGKEGCTMHVSPDQlwPHTKFledFING
 1513- 1554 (67.45/38.75)	LWlFAQLPDLLKEILGSILRDNEGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.94|      66|     355|     937|    1020|       4
---------------------------------------------------------------------------
  937- 1018 (102.40/107.35)	LIAEANKGS...APSStyvsaLLHVirHCSLCIKHA...RLTSQMD.ALDIP.FveevglrnASTNIW.....................FRlPFARDDSWQHI.CLRLGRPG
 1296- 1391 (85.55/51.29)	MLAAAGRGGpgiAPSS.....LLPI..DVSVVLRGPywiRIIYRKQfAVDMRcF........AGDQVWlqpatpakvnpsfggslpcpqFR.PFIMEHVAQELnGLEPNFPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.78|      14|      17|     782|     796|       5
---------------------------------------------------------------------------
  782-  796 (21.39/16.35)	GSYTALDDDHISmPS
  802-  815 (24.39/13.23)	GVYANRSSRLLS.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      26|      43|     820|     846|       6
---------------------------------------------------------------------------
  820-  846 (41.52/22.31)	PRISGSIKPNGSRSSpTAAPTGSLRPS
  866-  891 (45.16/20.30)	PVYESGLKNDSSRKR.TASDMLNLIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.72|      26|     235|    1226|    1251|       7
---------------------------------------------------------------------------
 1226- 1251 (47.34/28.84)	PARAGPVSTLPGIV.....ATLSSLPKHGGY
 1459- 1489 (42.38/24.95)	PLRRSPGTGVPAHVrgelnTAIIGLGDDGGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.85|      22|     379|    1392|    1438|       8
---------------------------------------------------------------------------
  619-  648 (36.10/ 8.92)	PNSAGNQTPENgllpdisiGGALQIAGYP..P
 1406- 1429 (36.75/30.54)	PNSSSQITAAN........GNRLSLPGSPamP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11774 with Med14 domain of Kingdom Viridiplantae
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