<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11767

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGGLHQISWFQFLPNESDLSTLPDKSAKVEHNDAATFLVLSSHVQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSVVETAQAAVSKLRVVASGLWISPGDSEEVAAALSQALRNCIERALTGLSYMRFGDVFTKYHHMQSEDLFRRGQPTMEFIFAATEEAIFVHVILSAKHIRALSNAEIERVLKNSAHNSCLGLPVIVSPHGVRGRFTGCCASDVVKRIYSSSGKSRTSYGFVGLPHHVSQGGCQSKGQNCYVEVTLGCPKSVSEKPLLSNSNYTKNVSMPQVTESLIGRGELKGSSNHLSSHKKTFIYPSEAVLVLLLQTSFARSSLKRFWLQNWIGPSLPGSSFNVHCAGNVDYMEGLWTETDKIRSQHGYDSSSNSNSSSIGSISSSSNDSDCKTGASELEADADSLSCRQSGLSSNDQSANSSRKLGIKRPRSGMPDALDQMGTGAQIQDAFKSDFTSTELIGSPWDWEDDDRGGDDIEDLLLHFGGFGDFFENDVLPFGEPPGTTESQSLMFSAPDYTDVGSSPVGVMDVSDQMLLPVGFPSFDSFNPAVPMMTEEVLSKDHEVTNNALSSVTANQTPVSSSGEFDQISKAEALMTLAPEYGAVETPTSEFSSSMFRSPYIPKTRELESSNLSTNSYIYGATPPSSPHFDRSDEKSGISSNTKPSNVLRAKNYYIHVDNVKEKHIRKSAPSKNSISTSDGLASSLSNHNAVKTTQRKMAEDSIEADCLFMSQKHVLAMEVECLMFQASMCRLRHTLQSSGSSTVSGTTQLSSDPSTITDYMANEVKKKETVPIRIAGDADGGILDGHLNAPVGVWRSVGVPKVPKPSNSPSMELGSSLPHNSFHEDGVLSYGQRQPLQELLDAFPLIVQQATSFVDLALDADCGDGPYGWLALQEQWRRGFSCGPSMVHAGCGGTLASCHALDIAGVELVDPLTADVYAPSVMSFLQSDMKTALKSAFGTLDGPLSVIDWCKGRGQLGDSGSTGDGLSAESTVNESKDSSSTVMQNLGEPISPSHSSASGSSSLKGSTTMDGSKMDETSQRRSNQEICSSGSDPQLLPSRLRPTVLVLPSPAILVGYQDDWLKTSANSLQLWEKAPLEPYAVQKPINYCVICPDIDPLATAAADFFQQLGTVYETCKLGTHTPHNLGNQMDTESGKWLSSGFVLLDCPQSMKIDSSSASIVGSISDYLLSLSNGWDLTSYLRSLSKALKALKLSPSMSANPKEGSNGSCMVLYVICPFPDPLEVLQTVVESSIAVGSVMLQSDRDRRTILCSQVAKSLSCSAAVDESSASNVLVLQGFTLPKLVLQIVTVDVIFRVSSPSVNELVILKETAFTIYNKARRISRGTSNDAVQSSSISSRSHSVLSSMSPSIPGMWKDCVGPRMTGHSLPREGEIDGTLRSGNWDNSWQSRAGTLNCDPNRMGEYYLQDDSCYMFEPLFILAEPGSLEHGVSPINPVTLGTESSKPLSDDNSGAFLQGTNSTVGMDIGSNSQLDGPEMDGFGCGHQKNPSLHCSYGWTEDWRWLVCIWTDSRGELLDSHIFPFGGISSRQDTKGLECIFVQVLQQGCMILQSCSPDTGVSKPRDLVIARIGMFYELEYLEWQKAIYSLWGSEVKKWPLQLRRCMPDGISSSTNGSSLQQQEMSLIHDRNLPSSPNPLYSPHSKTTGFMKAGIGQPAIRKQLMGGHAVVDNSRGLIQWVHSISFVAVSMEHSLQLLLQADSAPPGGNQGSVHTGSSMYIEGFTPVKSLGSTSSSYILIPSPSLRFLPSNPLQLPTCLTAESPPLAHLLHSKGSAVPLSTGFAISRAVPSMRKDTRSNMKEEWPSVLSVSLIDYYGNNITQEKNVRGIIKQVGRSSTVESRDFEIETHLILESIIAELHALSWMTVSPAYLDRRTALPFHCDMVLRLRRILHFADTELSRRAEKTKR
Length1950
PositionKinase
OrganismCucumis melo (Muskmelon)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Cucurbitales> Cucurbitaceae> Benincaseae> Cucumis.
Aromaticity0.07
Grand average of hydropathy-0.264
Instability index55.91
Isoelectric point5.63
Molecular weight211792.03
Publications
PubMed=22753475

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11767
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     854.64|     265|     285|    1289|    1571|       1
---------------------------------------------------------------------------
  921- 1063 (86.31/41.70)	QEQWRrGFSCgpsmVHAGCGGTLASCHALDIAGV..............................................................................................................................................................................................elvdpltadvyapsvmsflqsdmktalksafgtldgplsvidwckgrgqLGDSGSTGDG....LSAESTV.NES.KDSSstvmqnlgEPISPSHSSA..SGSSSLKG.....STTMDGSKMD..................
 1289- 1542 (361.03/250.12)	...................................SDRDRRTILC..SQVAKS.....LSCSAAVDESSASNVLVLQ.G..FTLPKLVLQivtvDVIFRVSSPSVNELVIlkETAFTIYNKARRISRGTSNDAVQSSSISSR....SHSVLSSMSPSIPGMWKDCVG.PRMTGHSLPREGEIDGTLRSGNWDNSWQSRAGTLNcdpNRMgEYYLQDDSCymfEP..............................................lfiLAEPGSLEHG....VSPINPV.TLG.TESS........KPLSDDNSGAFLQGTNSTVGMDIGSNSQLDGPEMDGFgcGHQKNPSLHCSYGW
 1543- 1825 (407.30/234.03)	TEDWR.WLVC....IWTDSRGELLDSHIFPFGGIsSRQDTKGLECifVQVLQQgcmilQSCSPDTGVSKPRDLVIARiGmfYELEYLEWQ....KAIYSLWGSEVKKWPL..QLRRCMPDGISSSTNGSSLQQQEMSLIHDRnlpsSPNPLYSPHSKTTGFMKAGIGqPAIRKQLMGGHAVVDNSRGLIQWVHSISFVAVSME...HSL.QLLLQADSA...PP.................................................GGNQGSVHTGssmyIEGFTPVkSLGsTSSS........YILIPSPSLRFLP.SNP...LQLPTCLTAESPPLAHL..LHSKGSAVPLSTGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.65|      69|     420|      52|     379|       2
---------------------------------------------------------------------------
  243-  313 (116.34/343.29)	SSSGKSRTSYGFVGLPHHVSQggCQSKGQNCYVEV.TLGCPKS.VSEKPLLSNSNYTKNVSMPQ..VTESL..IGRG
  397-  471 (96.31/26.90)	SSSNSNSSSIGSISSSSNDSD..CKTGASELEADAdSLSCRQSgLSSNDQSANSSRKLGIKRPRsgMPDALdqMGTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      18|     501|     359|     378|       3
---------------------------------------------------------------------------
  359-  378 (32.29/20.94)	IGPSLPGSSFnvHCAGNVDY
  861-  878 (35.21/17.22)	LGSSLPHNSF..HEDGVLSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.70|      19|     501|     473|     500|       4
---------------------------------------------------------------------------
   52-   71 (35.08/11.41)	QLQkEGFLSTWTNS.FVG.PWD
  473-  493 (28.62/29.91)	QIQ.DAFKSDFTSTeLIGsPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.49|      25|      34|     675|     699|       5
---------------------------------------------------------------------------
  675-  699 (42.90/19.42)	HFDRS.DEKSGISSNTKPSNVLRAKN
  711-  736 (35.59/14.92)	HIRKSaPSKNSISTSDGLASSLSNHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.11|      18|     501|     617|     634|       6
---------------------------------------------------------------------------
  533-  551 (28.56/20.04)	ESQSLMFSAPDYTDVgSSP
  617-  634 (31.55/23.12)	KAEALMTLAPEYGAV.ETP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11767 with Med13 domain of Kingdom Viridiplantae
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