<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11735

Description mediator of RNA polymerase II transcription subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLCKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSVVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGSSAPGPLQPKQPVPLPPTAPSGPPLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQTAAPQLPPGAPGAPKPPPVSQPSLVSTVAAGPGLASAVQPGAPSMAGSVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQSQGTVGASAATGQPQAQGAAQAPPGAPQGPPGTAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGGPTLLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQTSVMEDDILMDLI
Length747
PositionUnknown
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.05
Grand average of hydropathy-0.225
Instability index57.65
Isoelectric point8.57
Molecular weight78163.83
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11735
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     295.54|      60|      62|     206|     267|       1
---------------------------------------------------------------------------
  224-  285 (103.63/25.42)	RGLVLPVGGSSAPGPL...QPKQ..PVPLPPTAPSGPP...LSAAPQQPLPPvpqQYQVPGNLSaaQ.....VA.A
  331-  367 (44.92/ 6.33)	.......GAPGAPKPP...PVSQ..P.SLVSTVAAGPG...LASAV.QPGAP......................sM
  594-  646 (80.08/17.77)	.G...TVGASAATGQP...QAQG..AAQAPPGAPQGPP....GTAPGPP.PP..gPILRPQNPG..ANPQ.....L
  684-  747 (66.91/16.29)	QGLGQPQLG...P.PLlhpPPTQswPAQLPPRAPL.PGqmlLSGGPRGPVPQ..pGLQ..TSVM..EDDIlmDL.I
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.08|      34|     110|      35|      69|       2
---------------------------------------------------------------------------
   35-   69 (61.70/36.28)	LCKH..YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  145-  183 (47.38/23.18)	ICNSppYLLPAVESTTySGCTTES.LVQKIGerGIHFSVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.97|      19|     268|     292|     322|       3
---------------------------------------------------------------------------
  293-  319 (28.33/14.22)	KNQKAGLGPrfspinplQQAASGVGPP
  553-  571 (35.63/ 6.16)	EQQQRGMGA........QQAPPGLGPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     464|     487|       4
---------------------------------------------------------------------------
  464-  487 (34.11/31.12)	LFrnSRMVQF.HFTNKDLESLKGLY
  493-  515 (37.50/26.45)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.43|      16|      16|     648|     663|       5
---------------------------------------------------------------------------
  648-  663 (33.60/12.64)	SL.LLNPPPPQTGVPPP
  666-  682 (29.83/10.14)	SLhHLQPPGGPTLLPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11735 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSSAPGPLQPKQPVPLPPTAPSGPPLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGPPFSQTAAPQLPPGAPGAPKPPPVSQPSLVSTVAAGPGLASAVQPGAPSMAGSVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQSQGTVGASAATGQPQAQGAAQAPPGAPQGPPGTAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGGPTLLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQTSVMEDDILMD
232
544
390
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA