<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11734

Description mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKAQVNQKDNFWPVTARSQTAINTWFTDLAGTKPLTQLAKKVPIFGKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAALTETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVELAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGMSTHSSHMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGASGPRPPSPFDDPVDDPDRKEAEGSSSSKLEDPGLSESMDIDPNSSVLFEDIEKPDFSLFSPTMPCEGKGSPSPEKPDVDKEVKPPLKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPSAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGAEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLASSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYGQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGEHQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQRLSPWEIFEGLKPSASLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPATTLLEPEKKAPEPPKTDKPGAAPPNTEERKKKPTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPASMSHLSYRQTSLGLYTQNQPLPAGGPRVDPYRPIRLPMQKLPTRPPYPGVLPSTMTSVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPNYSNQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPSYAHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRTASILPEQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQQQILRQQQQQQQQQQQQQQQQQQAHQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2162
PositionKinase
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index55.41
Isoelectric point6.63
Molecular weight241232.79
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11734
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     279.69|      35|      35|    2051|    2085|       1
---------------------------------------------------------------------------
 1900- 1934 (50.00/19.30)	QQ............PAVPQGQ.....RLRQQ..........LQQSQGMLGQS............................SVHQMTPSSS
 1935- 1976 (40.21/14.03)	YG............LQTSQGYtpyvsHVGLQ..........QHTGPAGTMVP..........................pnYSNQPYQSTH
 1977- 2060 (27.16/ 7.00)	PStnptlvdptrhlQQRPSGY......VHQQapsyahgltsTQRFSHQTLQQtsmigtmtplgaqsvqagvrtasilpeqQQQQQQQQQQ
 2061- 2094 (67.52/28.73)	QQ............QQQQQQY.....HIRQQ..........QQQQQQQILRQ.............................QQQQQQQQQ
 2095- 2123 (54.47/21.71)	QQ............QQQQQQA.....H................QQQQAAPPQ............................PQPQSQPQFQ
 2124- 2153 (40.32/14.09)	RQ............GLQQ...........TQ..........QQQQTAALVRQ...........................lQQQLSNTQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.94|      30|      61|    1805|    1835|       2
---------------------------------------------------------------------------
 1805- 1835 (55.40/41.37)	PgRSGPY.GVTVP..........PDLLHHT.......NPASMSHLSYRQ
 1852- 1899 (39.53/23.00)	P.RVDPYrPIRLPmqklptrppyPGVLPSTmtsvmglEPSSYKTSVYRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.64|      64|     424|      66|     136|       3
---------------------------------------------------------------------------
   66-  136 (99.53/79.09)	PAK....ISSNFSSIIAekLRCN...TLPDTGRRKAQVNQKdnfwpVTARSQTAI......NTWFTDLAGTKPLTQL.AKKVPIF
  488-  565 (85.11/50.87)	PSKdgheISSDDDAVVS..LLCEwavSCKRSGRHRAMVVAK.....LLEKRQAEIeaercgESEAADEKGSIASGSLsAPSAPIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.60|      30|     233|     216|     251|       4
---------------------------------------------------------------------------
  216-  251 (49.32/42.58)	GSTIGPLPHDVEL....AIRQWDYNEKLamfmfqDGMLDR
  449-  482 (47.28/27.20)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.93|      25|     424|     365|     427|       6
---------------------------------------------------------------------------
  385-  410 (42.28/62.53)	SRIKTGSPLDHlPIAPSNLPMPEGNS
  628-  652 (47.65/ 7.41)	SGPRPPSPFDD.PVDDPDRKEAEGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.33|      41|      58|    1376|    1416|       7
---------------------------------------------------------------------------
 1376- 1416 (64.48/40.29)	SLLENIAKATIEVFQQSAETGSSGSTASNMPSSSKTKPVLS
 1436- 1476 (64.86/40.57)	SVQGHVLKAAGEELEKGQHLASSSSRKERDRQKQKSMSLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.69|      18|      18|    1733|    1750|      12
---------------------------------------------------------------------------
 1733- 1750 (36.58/16.70)	PRAYYLEP...LPLPPEDEEP
 1751- 1771 (30.11/12.39)	PATTLLEPekkAPEPPKTDKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.60|      15|      19|    1659|    1677|      14
---------------------------------------------------------------------------
 1659- 1677 (13.71/23.10)	TKgNKIAGFDsIFkkEGLQ
 1680- 1694 (28.89/18.12)	TK.QRLSPWE.IF..EGLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11734 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GASGPRPPSPFDDPVDDPDRKEAEGSSSSKLEDPGLSESMDIDPNS
2) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVN
3) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPNYSNQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPSYAHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRTASILPEQQQQQQQQQQQQQQQQQQQYHI
4) QQQQQQQQQQAHQQQQAAPPQPQPQSQPQFQRQGLQ
5) RAYYLEPLPLPPEDEEPPATTLLEPEKKAPEPPKTDKPGAAPPNTEERKKKPTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHTNPASMSHLSYRQTSLGLYTQNQPLPAGGPRVDPYRPIRLPMQKLPTRPPYPGVLPSTMTSVM
626
15
1887
2093
1734
671
63
2071
2128
1885










Molecular Recognition Features






MoRF SequenceStartStop




1) EERKKK
2) MAAFGI
3) NIFGRY
4) QQYHIRQ
5) YRPIRL
1779
1
2157
2067
1857
1784
6
2162
2073
1862