<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11733
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSDDDDAPADGDAHDWAGTGAGPGAEQDEDEGLVKFQPSLWPWDSVRNNLRNSLTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQCCFIPNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDVDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQSPDIGDLGTVNLFKRPLLKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQILSQPFPNLQLSISLCHSSNDKKSQKSTTEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASLPFGHKRMRLSGPQAFDKNEISSIQSTEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNISDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVVTLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVEWNKMEGRNFVYKMELLMSALSPCLL |
Length | 657 |
Position | Head |
Organism | Erinaceus europaeus (Western European hedgehog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae>
Erinaceus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.409 |
Instability index | 52.40 |
Isoelectric point | 6.88 |
Molecular weight | 73497.96 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11733
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 105.19| 34| 251| 1| 38| 1
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1- 38 (52.09/44.95) MSGVRAVRISIesacEKQVQEVGLDGT.ETYLQPLSMSQ
257- 291 (53.11/35.03) LEGSAYIKVSI....QKQSPDIGDLGTvNLFKRPLLKSK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 208.22| 67| 339| 148| 233| 2
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120- 143 (17.41/18.89) .............................................VRD..KKFM..TLDPVSQDALPPKQCCF.....
161- 233 (96.15/77.72) GAAQIllKGAERLTKSVT.ENQENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHHGTFEVIKN
504- 571 (94.66/54.42) GVEQI..RVVHRDGRVVTlSHQEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGL....GPIESIGN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 69.72| 21| 534| 96| 118| 7
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96- 118 (33.56/28.06) WDSVRNnlRNSLTEMCVLYDVLS
633- 653 (36.16/23.39) WNKMEG..RNFVYKMELLMSALS
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