<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11733

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSDDDDAPADGDAHDWAGTGAGPGAEQDEDEGLVKFQPSLWPWDSVRNNLRNSLTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQCCFIPNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDVDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQSPDIGDLGTVNLFKRPLLKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQILSQPFPNLQLSISLCHSSNDKKSQKSTTEKQSPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASLPFGHKRMRLSGPQAFDKNEISSIQSTEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNISDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVVTLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFKEVEWNKMEGRNFVYKMELLMSALSPCLL
Length657
PositionHead
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index52.40
Isoelectric point6.88
Molecular weight73497.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11733
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.19|      34|     251|       1|      38|       1
---------------------------------------------------------------------------
    1-   38 (52.09/44.95)	MSGVRAVRISIesacEKQVQEVGLDGT.ETYLQPLSMSQ
  257-  291 (53.11/35.03)	LEGSAYIKVSI....QKQSPDIGDLGTvNLFKRPLLKSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.22|      67|     339|     148|     233|       2
---------------------------------------------------------------------------
  120-  143 (17.41/18.89)	.............................................VRD..KKFM..TLDPVSQDALPPKQCCF.....
  161-  233 (96.15/77.72)	GAAQIllKGAERLTKSVT.ENQENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHHGTFEVIKN
  504-  571 (94.66/54.42)	GVEQI..RVVHRDGRVVTlSHQEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGL....GPIESIGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.72|      21|     534|      96|     118|       7
---------------------------------------------------------------------------
   96-  118 (33.56/28.06)	WDSVRNnlRNSLTEMCVLYDVLS
  633-  653 (36.16/23.39)	WNKMEG..RNFVYKMELLMSALS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11733 with Med17 domain of Kingdom Metazoa
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