<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11732

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLFSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFPGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQALDPNLEWTQISTRFLREQLAKISDFYHMTASAGEGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNSSGVGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKTANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWTNQNKDNQEVAPNDEAVVTLLCEWAVSSKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSITASTRPRSPAGENAEEHYPKDNDVKMEIFSPMPGEPCENANPPLGRRMSVNGEKLLKRERTRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTDTGVGDDGHKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHVQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSVNYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCLSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNSLKSDDFSMRGLRRDGNVEDIWIASQNSKSCSKGISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECSEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSSSGMGLFNPNGLGGPDTGTTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILCNWREERYQDDIKARQLMHEALQLRLNLVGGMFDTVQRSSQWTTEWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSSSPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKMSPWDLFEGQKNPAPLSWAWFGTVRMDRKVVKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNLYRVPPNYSPISSQMMPHPQSTLWGYNLMGQPQQPSFFLQSPSLTPGGSRLDPSGSFVPTNTKQALSNMLQRRSGAVMQPPSLHAITSQQQLIQMKLLQQQQQQQQQRLLRQAQARPFQQGQPGDQAALFAAQARPSPQLSQYPGLPQAQAMPQGYTMYGTQMPLQPTPQQQAASVVLSPGYNSRNYPATHSSAALIERLRQMQQPPSGYVQQQASPYLQPLAGAQRLNHQPLQQSPLVGGGIEAVLTSAHPGLPSVSLSQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQPSSQPQSQNLGLQAVQSQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2147
PositionKinase
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy-0.415
Instability index58.97
Isoelectric point7.91
Molecular weight239693.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     659.71|     198|     251|    1590|    1840|       1
---------------------------------------------------------------------------
 1604- 1858 (269.88/184.70)	VKKLKKELgdkRSESIDKVQQLLPLPKQTcDIITCEPMGSLidtkgnkiagfdsidKKQGLQVSTKQ.KMSPWDlfEGQknPAPLSwAWFGT.VRMDRKVVKYEEqhhllLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISqePERKSAELSdqgktATDEekktkgrkrktkSSSRVDEYPQsnLYRVPPNYspISSQMM.PHPQSTLWGYNLMGQPQQPSFFLQSPsLTPGGSRL.....dPS.....GSfvpTNTKQALSNM
 1859- 2059 (310.40/127.20)	LQR........RSGAVMQPPSLHAITSQQ.QLIQMKLLQQQ...............QQQQQQRLLRQaQARPFQ..QGQ..PGDQA.ALFAAqARPSPQLSQYPG.....LPQAQAMPQGYTMYGTQMPLQPTPQQQAASVVLS..PGYNSRNYP.....ATHS............SAALIERLRQ..MQQPPSGY..VQQQAS.PYLQPLAGAQRLNHQPLQ.....QSP.LVGGGIEAvltsahPGlpsvsLS...QDPMRPRQPQ
 2060- 2109 (79.43/27.39)	VRQQQRLL.........QMQQ.PPQPQQ................................................................................................................................................................................pPQPQPS.......SQPQSQNLGLQA......................vQS...QQPLFPRQGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.76|      54|     380|     894|     956|       2
---------------------------------------------------------------------------
  882-  926 (60.69/57.40)	CIVAVLRR.YHSC................lIlnPEQTAQVFEGL...CGvvKHVVNPSECSSPER
  927-  955 (24.26/23.93)	CILAYLYDlYVSCSHLRSKFGDlfSSACS....................................
 1122- 1174 (80.81/60.52)	EPGARM.....TCRLLLHLFRA..PQACL.L..PQATGKPFPGIrssCD..RHLLAAAHNSIEVG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.64|      66|     196|     979|    1072|       3
---------------------------------------------------------------------------
  805-  880 (97.10/47.52)	ISNNVLEQItSFASGTSYHLPLAHhvqlifdlmEPALNINGLIDFAIQLLNELSVVEAELL..LK....SSSLAGSYTTGLC
 1000- 1071 (111.55/114.79)	LSDNAANRY.SFVCNTLMNVCMGH.........QDAGRINDIANFSSELTACCTVLSSEWLgvLKalccSSNHVWGFNDVLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.01|      39|     152|     494|     536|       8
---------------------------------------------------------------------------
  494-  532 (61.31/31.38)	KDNQEVAPNDEAVVTLL........CEWAVSSKRSGKHRAMAVAKLL
  641-  685 (54.15/26.36)	ENAEEHYPKDNDVKMEIfspmpgepCENA..NPPLGRRMSVNGEKLL
  689-  721 (33.55/16.55)	RTRELIFPSNYDLLRHL.....qyaTHFPIPLDESSSH.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.25|      30|     203|    1300|    1330|      10
---------------------------------------------------------------------------
 1228- 1257 (39.07/20.42)	C.SKGISI..EtanlREYA.RYVLRTICQ....QEWVG
 1260- 1292 (33.10/15.46)	ClKEPERLctD....KELIlDPVLSNMQAQKLLQ.LIC
 1300- 1329 (53.08/32.15)	C.SEGDNL..Q....RQHI.KRILQNLEQWTLRQSWLE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11732 with Med12 domain of Kingdom Metazoa
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