<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11731

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTAAPQTQLQLQQVAIQQQQQFQQQQVALQQQQQQQQQQQFQAQQNVMQQQFQAVMQQQQQQLQQQQQQQQQQHLINKHLIQQNQQQIQQQQQQLQRMAQLQLQQQQQQQQALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQMITAALAQGGMQVRARFPPTTAVSAVPSSSIPLGGQPSAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPLVCSRKRKFEEDERQNIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLKSVHRCMTSKLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length789
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.03
Grand average of hydropathy-0.672
Instability index83.90
Isoelectric point9.50
Molecular weight86613.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11731
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.68|      31|      31|     152|     182|       1
---------------------------------------------------------------------------
  177-  210 (47.46/ 8.22)	QQQQQQqQFQAQQNVMQQ..QF.QavMQQQQQQLQQQ
  261-  293 (50.99/ 9.45)	PQIQQP.SMQQSQPPPSQalPQ.Q..LQQMHHAQHHQ
  335-  364 (44.22/ 7.09)	QQQPQL.KLVRAPMVVQQ..PQvQ..PQVQQV..QPQ
  426-  456 (44.01/ 7.02)	VSQNSL.TMLSSPSPGQQ..VQ.T..PQSMPPPPQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.80|      21|      37|      82|     105|       3
---------------------------------------------------------------------------
   92-  128 (19.08/10.05)	PAAgAAgiGMPSRGpgqslggmgglgaMGQP.........MPLSGQ
  294-  323 (34.72/10.13)	PPP.QS..QQPPVA.............QNQPsqlppqsqtQPLVSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     182.44|      36|      36|     546|     581|       7
---------------------------------------------------------------------------
  509-  544 (39.00/18.77)	PLNTPVNPssvmspaGSSQAEEQQYLDKLKQL........SKYI
  546-  581 (60.16/32.92)	PLRRMINK.......IDKNEDRKKDLSKMKSL.LDILTDPSKRC
  582-  606 (35.79/16.63)	PLKTL...........QKCEI...ALEKLKND.MAVPTPP....
  700-  734 (47.49/24.45)	SNNGTVHL.......ICKLDD..KDLPSVPPLeLSVPADYPAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.03|      42|     125|     609|     657|      10
---------------------------------------------------------------------------
  616-  657 (74.80/61.42)	QYLCQPLLDAVLANIRSPVF....NHSLYRTFVPAMTAIHGPPITA
  743-  788 (68.23/39.55)	QYDANPFLKSVHRCMTSKLLqlpdKHSVTALLNTWAQSIHQACLSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.68|      15|      17|     365|     380|      16
---------------------------------------------------------------------------
  365-  380 (20.76/11.13)	VQQQTAvPTAQTSQIV
  384-  398 (23.92/ 9.17)	VQMITA.ALAQGGMQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11731 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQP
2) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTA
3) QPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQMITAALAQGGMQVRARFPPTTAVSAVPSSSIPLGGQPSAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
256
70
351
338
147
539










Molecular Recognition Features






MoRF SequenceStartStop




NANANA