<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11730

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTAAPQTQLQLQQVAIQQQQQFQQQQVALQQQQQQQQQQQFQAQQNVMQQQFQAVMQQQQQQLQQQQQQQQQQHLINKHLIQQNQQQIQQQQQQLQRMAQLQLQQQQQQQQALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPLVCSRKRKFEEDERQNIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLKSVHRCMTSKLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length749
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.03
Grand average of hydropathy-0.721
Instability index85.69
Isoelectric point9.40
Molecular weight82678.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11730
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.93|      31|      31|     152|     182|       1
---------------------------------------------------------------------------
  176-  209 (47.30/ 9.69)	QQQQQQQ....qQFQAQQNVMQQ..Q.FQavMQQQQQQLQQ
  260-  292 (52.17/11.73)	QPQIQQP.....SMQQSQPPPSQalP.QQ..LQQMHHAQHH
  293-  329 (42.20/ 7.57)	QPPPQSQqppvaQNQPSQLPPQS..QtQP..LVSQAPTLPG
  385-  415 (45.26/ 8.84)	QVSQNSL.....TMLSSPSPGQQ..V.QT..PQSMPPPPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.98|      33|      36|     416|     451|       2
---------------------------------------------------------------------------
  416-  442 (43.36/14.59)	............SP....QPGQPNSQP.....NSNVSSGP..AP.SPS...SFL
  443-  480 (31.80/14.92)	PSPSPqpsQspvTA....RTPQNFSVP.........SPGPlnTPvNPS...SVM
  535-  567 (34.82/10.58)	TDPSK...R...CPlktlQKCEIALEK.....LKNDMAVP..TP.PP.......
  568-  604 (32.00/ 9.05)	.PPVP........P....TKQQYLCQPlldavLANIRS.P..VF.NHSlyrTFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.42|      17|      17|     224|     240|       3
---------------------------------------------------------------------------
  150-  167 (26.97/ 6.65)	QTQLQLQqVAIQQQQQFQ
  234-  251 (29.45/ 8.08)	QQQQQLQrMAQLQLQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.02|      22|      36|      82|     105|       4
---------------------------------------------------------------------------
   82-  105 (36.21/24.57)	MNALQSLTGGPAAGAAgiGMPSRG
  119-  140 (47.80/26.76)	MGQPMPLSGQPPPGTS..GMPPHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.86|      15|      15|     337|     351|       5
---------------------------------------------------------------------------
  213-  228 (20.85/ 6.21)	QQQQQhLINKHLIQQN
  337-  351 (26.76/10.59)	QPQLK.LVRAPMVVQQ
  355-  367 (25.25/ 9.48)	QPQVQ.QVQ.PQ.VQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.65|      17|      45|     616|     636|       7
---------------------------------------------------------------------------
  616-  636 (25.23/29.65)	TAPLVCsrkrKFEEDERQNIP
  664-  680 (30.42/22.33)	TVHLIC....KLDDKDLPSVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11730 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTA
256
70
499
147










Molecular Recognition Features






MoRF SequenceStartStop




NANANA