<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11728

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLSFLQADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSSSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEVFEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGASHCSASCLGVHQVPASARDPAMSSVTLTPPTSPEEVQTVDPQSAQKWIKFSSVSDGFSSDSTSHHGGKIPQKLANHVVDRVWQECNMNRAQNKRKYSASSSGLCEEEIADKVASWDFVEATQRTNCSCLRHKNLKLRNPGQQGQVPSLNQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISASDSQVRFSNIRTNDVAKTPQMHGTEMTNSPQPPPLSPHPCDAVDEGVTKTPSTPQSQNFYQMPTPDPLVPSKPMEDRIDNLSQSFPAQFQESVEPTVYVGTAVNLEEDEATVAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQENVTSVTELMVQFKKPLKVSDELVQQYQIKNQYLATVASEAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGPSNVTVLSHEEDAMSLFSPSIKQDVPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVNGSDDKSSCKESKTGTLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYCSMDITPGGTVLEGNNSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQYLPPIKLPEECVYRQSWIVGKLELLPSGPTMPFIKEGDGNTMDQEYGAAYTPQTHTSFGMPPSSAPPSNGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSTEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDFCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDFSVQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALINGAKSFFRDLTAMYESCRLGQHRPISRLLTDGIMRVGSTASKELSEKLVGEWFSQAADGNNEAFSKLKLYAQVCKYDLGPYLASQPLDNSLLSQPNLIAPTSQSLITPPQMTNTGNANNPSTTLASTASSTMTSGVAMSSSVVTANSTLTTASTSSSSSSNLISSNKLPLFPPFGNINNSAAGSMSTQTSTVQNGQLGGQQSSALQTAGLSGESSSLPIQPHPDVSESTMDREKVGIPTDGDSHAITYPPAIVVYLIDPFTYENKDESTNSSSIWTLGLLRCFLEMVLTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAIETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVALEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGGDAMGIFDLLDTGDDLDPDIISILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2152
PositionMiddle
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.08
Grand average of hydropathy-0.393
Instability index52.12
Isoelectric point5.36
Molecular weight237774.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP11728
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.68|      24|      24|    1472|    1495|       1
---------------------------------------------------------------------------
 1472- 1495 (42.09/26.15)	TP...P.QMTNTGNANNPSTTLASTASS
 1498- 1522 (31.78/17.57)	TS...GvAMSSSVVTANSTLTTASTSSS
 1529- 1555 (35.81/20.92)	SSnklP.LFPPFGNINNSAAGSMSTQTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.21|      49|     712|     270|     344|       2
---------------------------------------------------------------------------
  291-  344 (74.83/67.20)	GVHQVPASARDPamSSVTLTPPTSPEEVQtvDPQSAQKWIKFSSvSDGFSSDST
  982- 1030 (88.38/32.82)	GILPSPSTPRFP..TPRTPRTPRTPRGAG..GPASAQGSVKYEN.SDLYSPAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.44|      47|     420|     510|     556|       3
---------------------------------------------------------------------------
  447-  493 (63.57/29.63)	EKSEKPQKRPLTPfhHRVS.ISDDVGM..DTDSA..SQRLVISASDSQVRFS
  510-  556 (86.32/42.89)	EMTNSPQPPPLSP..HPCD.AVDEGVT..KTPSTPQSQNFYQMPTPDPLVPS
  573-  619 (57.55/26.13)	QFQESVEPTVYVG..TAVNlEEDEATVawKYYKVPKKKDVEFLP...PQLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.63|      26|      27|     889|     915|       4
---------------------------------------------------------------------------
  889-  915 (45.44/25.73)	PENCqVLVGCSMFAPLKTLPS.QYLPPI
  918-  944 (43.87/20.78)	PEEC.VYRQSWIVGKLELLPSgPTMPFI
  953-  972 (32.33/13.46)	DQE....YG.AAYTP.QTHTS.FGMPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.13|      16|      27|    1419|    1436|       5
---------------------------------------------------------------------------
 1419- 1436 (22.10/17.75)	SQAADgnNEAFSKLKLYA
 1449- 1464 (28.04/15.28)	SQPLD..NSLLSQPNLIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.18|      34|     422|    1646|    1705|       6
---------------------------------------------------------------------------
 1611- 1644 (60.87/42.69)	ITYPPAI...VVYLIDPFTYENKDESTNSSSIWTLGL
 1653- 1689 (57.31/57.89)	LTLPPHIkstVSVQIVPCQYLLQPVKHEDRQIYTQHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.75|      29|      30|    1083|    1111|       9
---------------------------------------------------------------------------
 1083- 1111 (54.67/35.51)	MNIK.GADVGVYIPDPTQEAQYRCTCGFSA
 1113- 1142 (46.09/28.68)	MNRKfGNNSGLFLEDELDIIGRNTECGKEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.71|      27|      30|    1811|    1837|      10
---------------------------------------------------------------------------
 1811- 1837 (53.58/33.85)	GSARRFGLQKLWEW.C.LGLVQMSSLPWR
 1841- 1869 (41.13/24.18)	GRLGRIGHGELKDWsClLSRRNLQSLSKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.85|      15|     468|     270|     288|      18
---------------------------------------------------------------------------
  270-  288 (25.75/23.83)	P..QSDIPTPssvgASHC...SAS
  734-  753 (20.10/ 8.21)	PsiKQDVPRP....ASHArppSTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11728 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CLRHKNLKLRNPGQQGQVPSLNQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISASDSQVRFSNIRTNDVAKTPQMHGTEMTNSPQPPPLSPHPCDAVDEGVTKTPSTPQSQNFYQMPTPDPLVPSKPMEDRIDNLSQSFP
2) FGNINNSAAGSMSTQTSTVQNGQLGGQQSSALQTAGLSGESSSLPIQPHPDVSESTMDREKVGIPTDG
3) FPDKKDRQNSEREAGKKHKVEDGPSNVTVLSHEE
4) PTMPFIKEGDGNTMDQEYGAAYTPQTHTSFGMPPSSAPPSNGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
5) SPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
6) SQSLITPPQMTNTGNANNPSTTLASTASST
410
1539
693
939
2000
1467
571
1606
726
1022
2030
1496










Molecular Recognition Features






MoRF SequenceStartStop




NANANA