<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11728
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MLSFLQADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSSSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEVFEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGASHCSASCLGVHQVPASARDPAMSSVTLTPPTSPEEVQTVDPQSAQKWIKFSSVSDGFSSDSTSHHGGKIPQKLANHVVDRVWQECNMNRAQNKRKYSASSSGLCEEEIADKVASWDFVEATQRTNCSCLRHKNLKLRNPGQQGQVPSLNQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGMDTDSASQRLVISASDSQVRFSNIRTNDVAKTPQMHGTEMTNSPQPPPLSPHPCDAVDEGVTKTPSTPQSQNFYQMPTPDPLVPSKPMEDRIDNLSQSFPAQFQESVEPTVYVGTAVNLEEDEATVAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQENVTSVTELMVQFKKPLKVSDELVQQYQIKNQYLATVASEAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGPSNVTVLSHEEDAMSLFSPSIKQDVPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSVNGSDDKSSCKESKTGTLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYCSMDITPGGTVLEGNNSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQYLPPIKLPEECVYRQSWIVGKLELLPSGPTMPFIKEGDGNTMDQEYGAAYTPQTHTSFGMPPSSAPPSNGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSTEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGAADQDPFPKIGVISNWVRVEERDFCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDFSVQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALINGAKSFFRDLTAMYESCRLGQHRPISRLLTDGIMRVGSTASKELSEKLVGEWFSQAADGNNEAFSKLKLYAQVCKYDLGPYLASQPLDNSLLSQPNLIAPTSQSLITPPQMTNTGNANNPSTTLASTASSTMTSGVAMSSSVVTANSTLTTASTSSSSSSNLISSNKLPLFPPFGNINNSAAGSMSTQTSTVQNGQLGGQQSSALQTAGLSGESSSLPIQPHPDVSESTMDREKVGIPTDGDSHAITYPPAIVVYLIDPFTYENKDESTNSSSIWTLGLLRCFLEMVLTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAIETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVALEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGGDAMGIFDLLDTGDDLDPDIISILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML |
Length | 2152 |
Position | Middle |
Organism | Erinaceus europaeus (Western European hedgehog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae>
Erinaceus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.393 |
Instability index | 52.12 |
Isoelectric point | 5.36 |
Molecular weight | 237774.74 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11728
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 109.68| 24| 24| 1472| 1495| 1
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1472- 1495 (42.09/26.15) TP...P.QMTNTGNANNPSTTLASTASS
1498- 1522 (31.78/17.57) TS...GvAMSSSVVTANSTLTTASTSSS
1529- 1555 (35.81/20.92) SSnklP.LFPPFGNINNSAAGSMSTQTS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 163.21| 49| 712| 270| 344| 2
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291- 344 (74.83/67.20) GVHQVPASARDPamSSVTLTPPTSPEEVQtvDPQSAQKWIKFSSvSDGFSSDST
982- 1030 (88.38/32.82) GILPSPSTPRFP..TPRTPRTPRTPRGAG..GPASAQGSVKYEN.SDLYSPAST
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 207.44| 47| 420| 510| 556| 3
---------------------------------------------------------------------------
447- 493 (63.57/29.63) EKSEKPQKRPLTPfhHRVS.ISDDVGM..DTDSA..SQRLVISASDSQVRFS
510- 556 (86.32/42.89) EMTNSPQPPPLSP..HPCD.AVDEGVT..KTPSTPQSQNFYQMPTPDPLVPS
573- 619 (57.55/26.13) QFQESVEPTVYVG..TAVNlEEDEATVawKYYKVPKKKDVEFLP...PQLPS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 121.63| 26| 27| 889| 915| 4
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889- 915 (45.44/25.73) PENCqVLVGCSMFAPLKTLPS.QYLPPI
918- 944 (43.87/20.78) PEEC.VYRQSWIVGKLELLPSgPTMPFI
953- 972 (32.33/13.46) DQE....YG.AAYTP.QTHTS.FGMPP.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.13| 16| 27| 1419| 1436| 5
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1419- 1436 (22.10/17.75) SQAADgnNEAFSKLKLYA
1449- 1464 (28.04/15.28) SQPLD..NSLLSQPNLIA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 118.18| 34| 422| 1646| 1705| 6
---------------------------------------------------------------------------
1611- 1644 (60.87/42.69) ITYPPAI...VVYLIDPFTYENKDESTNSSSIWTLGL
1653- 1689 (57.31/57.89) LTLPPHIkstVSVQIVPCQYLLQPVKHEDRQIYTQHL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 100.75| 29| 30| 1083| 1111| 9
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1083- 1111 (54.67/35.51) MNIK.GADVGVYIPDPTQEAQYRCTCGFSA
1113- 1142 (46.09/28.68) MNRKfGNNSGLFLEDELDIIGRNTECGKEA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 94.71| 27| 30| 1811| 1837| 10
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1811- 1837 (53.58/33.85) GSARRFGLQKLWEW.C.LGLVQMSSLPWR
1841- 1869 (41.13/24.18) GRLGRIGHGELKDWsClLSRRNLQSLSKR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.85| 15| 468| 270| 288| 18
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270- 288 (25.75/23.83) P..QSDIPTPssvgASHC...SAS
734- 753 (20.10/ 8.21) PsiKQDVPRP....ASHArppSTS
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