<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11727

Description mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDILDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAEWLREGLEAGSPAAGEKQLALCLQRLEKILSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGALIRSIPTMLSVHSEQLHRTGFPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTDFLLQECSKQGLLSEACKDNLMAKRAADREHAPQLKSGENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSEESTKAASVRALLFDISFLMLCHVAQTYGSEVILSESSTGVEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFLSTGVDTMPYWNLLPPKRPIKEVLTDIFARVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYISLFPLDDMQPSKLMRLLSSNEEDTNILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSCTAGPHTQFVQWFMEECVDCLEQGSRGSILQFMPFTTVSELVKVSAMSSPKVVLAISDLSLPLGRQVAAKAIAAL
Length989
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy0.040
Instability index48.28
Isoelectric point6.17
Molecular weight110209.98
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11727
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     585.89|     174|     194|     193|     377|       1
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   44-  153 (80.80/41.31)	.............................................................................EALLEQAMIGPS....PNPLIL......................SYLKYAISSqMVSYSSVLTAISKF.....DDFSRD..L.CvqalldildmfcdrlschgkAEEciglcraLLSALHWLL.....RC.TAASAEW.....L.REGLEAG..S....PAA
  193-  377 (277.65/197.60)	EHS.LLKLGEIlANL.SNPQLRSQAEQcgALIRSIPTMLSVHSEQlhRTGFPTVHAVVLLEGTMNL.......TGetQPLVEQLMMVKRmQHIPTPLFVL....EIWKACFVGLIESPEGTEELKWTAFT.FLKIPQVLVKLKKYSHG.DKDFTED..VNC....................AFE.......FLLKLTPLLdkaDQRC.NCDCTDF.....LLQECSKQGLLS....EAC
  390-  578 (227.44/134.86)	EHApQLKSGEN.ANIqPNPGLILRAEP..TVTNILKTMDADHSKS..PEGLLGVLGHMLSGKSLDLllaaaaaTG.......KLKSFAR.KFINLNEFTThgseESTKAASVRALLFDISFLMLCHVAQT.YGS..EVI..LSESSTGvEVPFFETwmQTC....................MPE.......EGKILNP.....DHPCfRPDSTKVeslvaLLNNSSEMKLVQmkwhEAC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11727 with Med24 domain of Kingdom Metazoa
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