<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11726

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWNETFKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMHWKATNAGPLEKILHGSVGYLSPRSGGHLMNLKYYASPSDLLDDKTASPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLVIGSHPADNKLTPSFSSITGANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSGSPRMEMSSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADATGSPSSDSPTNHFFADGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQTLNTLGVPVLGGDNGETKFKGGSQADTVDFSIITVGGKALGPAELMDHHSGSQSPLLTSGDLGKEKTQKRVKEGNGTSNPGLSGSGLDSKPGKRSRTPSNDGKSKDKPPKRKKADADGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGLSSSKLSSSIYTSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGSSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSAGMKSSSGLGSSGSLSQKTPSSNSCTTSSSSFSSSSSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSHSVSSKHSMLGGEFQGKREKSDKDKSKGSTAGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDKDRDKKKSHSIKPESWSKSPISSDQPLSLTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1577
PositionMiddle
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.04
Grand average of hydropathy-0.670
Instability index54.28
Isoelectric point8.90
Molecular weight167699.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     502.60|      50|      50|    1082|    1131|       1
---------------------------------------------------------------------------
  982- 1027 (50.73/11.17)	LSG.SGLDSK...PG.KRSR.....TPSNDGKSKDKP.PK..RKK...A..DADGKSP..SHSSSN
 1030- 1080 (48.24/10.21)	FTP.PT..ST...GG.SKSPGS.SGRSQTPPGVATPPiPKitIQI...P..KGTVMVG..KPSSHS
 1082- 1131 (83.28/23.68)	YTS.SGSVSS...SG.SKSHHS.HSSSSSSSSSASNS.GK..MKS...S..KSEGLSS..SKLSSS
 1133- 1171 (49.34/10.63)	YTS.QGS.SG...SG............QSKNSSQS.G.GK..PGS...SpiTKHGLSS..GS.SST
 1173- 1208 (43.95/ 8.56)	MKP.QGKPSSlmnPL.SKPNIS.PSH......................S..RPPG.SS..DKLASP
 1209- 1258 (63.21/15.97)	MKPvPGTPPS...SK.AKSPIS.SGSGGSHMSGTSSS.AG..MKS...S..SGLG.SS..GSLSQK
 1266- 1312 (40.03/ 7.05)	TTS.SSSFSS...S..........SSSMSSSQNQHGS.SK..GKSpsrN..KKPSLTAviDKLKHG
 1375- 1427 (43.62/ 8.44)	KTSeSKNVGS...TGvAKIIISkHDGGSPSIKAKVTL.QK..PGE...S..SGEGLRP..QMASSK
 1429- 1464 (38.86/ 6.61)	Y....GSPLI...SG.STPKHE.RGSPSHSKSPAYTP.QN..L.D...S..ESE............
 1507- 1554 (41.35/ 7.56)	DKD.RDRDKD...RD.KKKSHS.IKPESWSKSPISSD.QP..LSL...T..SNTILST..DRPS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.03|      16|      22|     876|     896|       2
---------------------------------------------------------------------------
  876-  896 (26.14/22.65)	GFGEEYFdessqSGDNDD..FKG
  904-  921 (23.90/ 9.57)	TLGVPVL.....GGDNGEtkFKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     143.51|      25|      65|     629|     653|       3
---------------------------------------------------------------------------
  541-  563 (24.71/ 7.90)	.P..PAS......SpgY...GMTTGNNPMSGT...TTP
  629-  653 (45.58/23.00)	PP..PVS......S..M...AGNTKNHPMLMNLLKDNP
  674-  699 (25.91/ 8.77)	SPrmEMS......S..G...SNKTKKKKS.SRLPPDKP
  734-  758 (23.98/ 7.38)	TP..HITpapsqcS..T...PPTTYPQPV......PHP
  759-  786 (23.33/ 6.90)	QP..SIQ......R..MvrlSSSDSIGPDVTDILSDIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     586.93|     161|     165|     112|     273|       4
---------------------------------------------------------------------------
   11-  154 (171.67/91.51)	.............................EKLSKMSSllerLHAKFNQNRPWNE...............TFKLVRQVMEKRvvmsS.GGH....QHLVSCLETLQKalKVTSlPAMT....DRlESIARQNGLGSHLSA..SGTECYITSDMFYV.......eVQLDPA.GQ..LC...DVKVAHHGENPVSCPELVQQLREK..NFDEFSKHL
  155-  311 (242.42/136.24)	KGLV.NLYNLPGDNKLKTK.MYLALQSLeQDLSKMAV....MHWKATNAGPLEK...............ILHGSVGYLSPR....S.GGHLMNLKYYASPSDLLDD..KTAS.PIIL....HE.NNVPRSLGMNASVTI..EGTSAMYKLPIAPL.......vIGSHPAdNK..LT...PSFSSITGANSVDLPACF.........FLKFPQPI
  315-  493 (172.83/92.41)	RAFVqKLQSCTGIPLFETQpTYVPLYEL...ITQFEL....S..KDPDPIPLNHnmrfyaalpgqqhcyFLNKDAPLPDGR....SlQGTLVSKITFQHPGRV..........PLILnlirHQ.VAYNTLIGSCVKRTIlkEDSPGLLQFEVCPLsesrfsvsFQ.HPV.NDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      20|      20|    1324|    1343|       5
---------------------------------------------------------------------------
 1324- 1343 (35.06/18.40)	MDGQMGVSTNSSHSVSSKHS
 1345- 1364 (31.91/15.94)	LGGEFQGKREKSDKDKSKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.54|      23|      42|     803|     826|       6
---------------------------------------------------------------------------
  803-  826 (37.37/24.60)	GTPVRDSSSSgH..SQSALFDPDVFQ
  846-  870 (38.17/20.07)	GSPSSDSPTN.HffADGVDFNPDLLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.18|      13|      21|     590|     602|       7
---------------------------------------------------------------------------
  590-  602 (24.17/12.67)	GHGEDFSKVSQNP
  612-  624 (24.01/12.52)	GNGGSTIGSSPTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11726 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSIITVGGKALGPAELMDHHSGSQSPLLTSGDLGKEKTQKRVKEGNGTSNPGLSGSGLDSKPGKRSRTPSNDGKSKDKPPKRKKADADGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGLSSSKLSSSIYTSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGSSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSAGMKSSSGLGSSGSLSQKTPSSNSCTTSSSSFSSSSSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSHSVSSKHSMLGGEFQGKREKSDKDKSKGSTAGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDKDRDKKKSHSIKPESWSKSPISSDQPLSLTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSGSPRMEMSSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADATGSPSSDSPTNHFFADGVDFN
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQTLNTLGVPVLGGDNGETKFKGGSQADT
930
538
575
868
1577
571
865
927










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFD
2) IRPLPEYSTEKHKKHKKEKKKVKD
3) KITIQIPK
4) KPSLTAVIDKLKHGV
5) RLSPDFMIGEEDDDLMDV
6) SIKAKVTLQK
7) VAKIIISKH
877
1484
1061
1299
1555
1401
1387
883
1507
1068
1313
1572
1410
1395