<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11722

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHDLQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHVTVGQQGLGSAKDPSNCGLPLTPPTSPEQAVMGESGATQSAVCHPGSQDTGMVTMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPVNSPATWDFVDPTQRVSCSCSRHKLLKRCAVGSSRPPTISQPGFSAGPSSSASLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPCVAEELCMEQDPPGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNTSRQMNLNPMDSPHSPVSPLPPTLSPQPRGQETESLDPPSVPVNPALYGSGLELQQLSTMDDRTVLVGQRLPLMAEVSETALYCGVRPSNSDSSDKWWHSYRLPPIDDAEFRPPELQGERCDARMEVNSESTALQRLLAQPNKRFKIWHDKQSQTQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNTAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEHHPAFSPVMSYKDGLTSETVTALGMMESPMVSIVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTYLPQLEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISLNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHAWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWEKLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQAPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGGSTNPAASSSTSGSSVPPVSSSASAPVMNQISTTSSSGFSGSVGGQNPSTGANSADRPQGNMGCSGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECALQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNRL
Length2211
PositionMiddle
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy-0.386
Instability index57.00
Isoelectric point5.68
Molecular weight242941.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11722
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.79|      23|      24|    1595|    1617|       1
---------------------------------------------------------------------------
 1016- 1037 (22.86/ 7.23)	...........PQM..NTpVTLNSAAPASNSGAGV
 1564- 1584 (26.46/ 9.71)	NP............tsNG.GSTNPAAS.SSTSGSS
 1585- 1615 (31.24/13.01)	VP.pvsssasaPVM..NQ.ISTTSSSGFSGSVGGQ
 1616- 1648 (31.23/13.00)	NPstgansadrPQG..NMgCSGDTEPGQSSSQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1127|    1151|       2
---------------------------------------------------------------------------
 1127- 1151 (51.64/30.20)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1154- 1182 (36.91/19.56)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.79|      17|      21|    1230|    1250|       4
---------------------------------------------------------------------------
 1233- 1250 (27.45/23.80)	HTQPFASLSFlDYISL.NN
 1252- 1269 (29.34/11.76)	QTLPCVSWSY.DRVQAdNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     267.37|      60|     626|     405|     470|       5
---------------------------------------------------------------------------
  405-  464 (110.29/47.06)	PVNSPATWD..FVDPTQRVSCSCSRHKLLKR.....CAVGSSRPPTIS.QPGFSAGPSSSASLP..........PPAS
  519-  574 (74.55/27.24)	.VSSSRKYDkqMAVPSRNTSRQMNLNPMDSP.....HSPVSPLPPTLSpQP...RG.QETESLD..........PP..
 1039- 1107 (82.54/32.26)	P..SPATPR..FSVPTPRTPR....TPRTPRgggtaSGQGSVKYDSTD.QGSPASTPSTTRPLNsvepatmqpiPEAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.61|      16|      21|    1707|    1726|       6
---------------------------------------------------------------------------
 1707- 1726 (21.75/20.80)	C.YteMLDNLPEHmrNSFILQ
 1730- 1746 (26.86/12.46)	CqY..MLQTMKDE..QVFYIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.29|      22|      22|     967|     988|       7
---------------------------------------------------------------------------
  967-  988 (43.98/28.74)	PDACLFRPSWAIPPKIEQLPMP
  989- 1010 (39.30/24.69)	PAATFIRDGYNNVPSVGSLADP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      18|      22|    2001|    2018|       8
---------------------------------------------------------------------------
 2001- 2018 (32.43/19.05)	PTSSTIQVA...PANYPNEDG
 2021- 2041 (29.46/16.53)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.65|      14|      22|    1376|    1392|       9
---------------------------------------------------------------------------
 1388- 1409 (13.99/ 8.78)	GYDKD..fltiSPFSlpfwEKLLL
 1413- 1432 (20.66/ 7.87)	GGHRDvayivvCPEN....EALLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.23|      54|     628|    1450|    1510|      10
---------------------------------------------------------------------------
 1450- 1510 (76.79/72.41)	LGQHKPicKVLRDGIMRVGKTVAQKLTDELvSEWFnqpWSS.EENDNHSRLKLYAQVcRHHL
 2083- 2137 (92.44/58.84)	LSREAP..EELKQQPLALGYFVSTAKAENL.PQWF...WSScPQAQNQCPLFLKASL.HHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.81|      17|     628|     309|     325|      11
---------------------------------------------------------------------------
  309-  325 (35.00/16.91)	QQGLGSAKD..............................PSNCGLPL
  918-  964 (19.81/ 6.18)	EDGLGSPKPeeikdfsyvhkvpsfqpfmgssmfaplkmlPSQCLLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.45|      25|      27|      60|      84|      12
---------------------------------------------------------------------------
   60-   84 (48.68/35.19)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (48.77/35.28)	FWWGDEPNLVGVIHHDLQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.86|      38|     364|     465|     504|      13
---------------------------------------------------------------------------
  465-  504 (65.52/52.09)	SKHKTTERQEKGDKLQKRPLIPFHhrPCVAEELCMEQDPP
  832-  869 (69.34/47.67)	SKIPTVGTEDRPLGKDGRAAVPYP..PTVADLQRMFPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.81|      25|      27|    1859|    1885|      14
---------------------------------------------------------------------------
 1859- 1885 (40.53/32.34)	I...ALPNRSRRSKVSarKIGLQKLWEWCI
 1888- 1915 (40.29/25.39)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.55|      10|     913|     180|     189|      16
---------------------------------------------------------------------------
  180-  189 (19.55/10.75)	SVEIAQHQPI
 1094- 1103 (20.00/11.19)	SVEPATMQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      16|      17|     767|     782|      17
---------------------------------------------------------------------------
  767-  782 (27.53/18.15)	DGKNAMSIFSSATK.TD
  786-  802 (22.80/13.63)	DNTAGRAGSSSLTQvTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      22|    1340|    1357|      18
---------------------------------------------------------------------------
 1340- 1357 (33.04/17.14)	KKRTGRTWENIQHVQGPL
 1363- 1380 (32.51/16.75)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.80|      41|      49|     591|     637|      19
---------------------------------------------------------------------------
  592-  634 (72.06/62.45)	LSTMDDRTV....LVGQRLPLMAEV.SE.TALYCGVRPSNSDSsdKWWH
  638-  684 (61.75/33.25)	LPPIDDAEFrppeLQGERCDARMEVnSEsTALQRLLAQPNKRF..KIWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     225|     240|      20
---------------------------------------------------------------------------
  225-  238 (24.00/18.68)	YKMSDPATRKLIEE
  243-  256 (23.41/ 8.96)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      13|      24|    1953|    1965|      23
---------------------------------------------------------------------------
 1953- 1965 (24.21/15.77)	AMEPQGSFVVMPD
 1978- 1990 (22.58/14.09)	ALNMQSSQLNTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.08|      21|     110|     692|     715|      27
---------------------------------------------------------------------------
  693-  715 (30.68/27.42)	LHFLDPLpLSQQPGDSLGEVNdP
  807-  827 (38.40/17.64)	LHDLDNI.FDNSDDDELGAVS.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11722 with Med13 domain of Kingdom Metazoa
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