<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11715

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKWPRSTHCPSVPLACAWSCRNLIAFTTDLRNDEQDLTRTIHILDTEHPWDVHSIPSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESLTGSLVEGDPIVALSWLHNGVKLALHVEKSAASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLRPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFFKVCVSVVSDKCHIDTEILPSLFMRCTTDLARRDKFPAVTHLRFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTQFYPGLGLALAFHDGSVHIVHRLSLQSMAVFYGAAAPRSLDEPALKRPRPAGPAVHFKAVQLSWTSLALVAIDSHGKLSLLRVSPSLGHPLEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQSASLQQVLSTRILAMKASLCKLSPCTLTRVCDYHAKLFLIAVSSTLKSLLRPHFLNTPDKSPGDRLSEVCAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLTSLPNQGSPLRPGHSFLRDGPSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWTSCRDEGPANEPDETLLDECCLLPSQLLPPRLDWLPVSDGLASRLQPKQPLRLRFGQAPALPSSATALQLDGLLRAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLRSPNAATAVQQWEQRWTKNCLCGGLWRRLPRSCP
Length829
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy0.020
Instability index55.32
Isoelectric point7.72
Molecular weight91807.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11715
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.31|      30|     188|     441|     470|       1
---------------------------------------------------------------------------
  441-  470 (52.53/24.34)	SLLRVSPSLGHPLEVSLALRHLLFLLEYCM
  632-  661 (52.78/24.48)	SFLRDGPSLGMLRELMVVIRIWGLLKPSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.37|      27|     188|      71|     119|       2
---------------------------------------------------------------------------
   71-   97 (51.34/18.92)	AITCLEW...DQSGSRLL..SADADGQIKCWS
  121-  131 ( 3.81/24.29)	...ALSW...LHNGVKL...............
  267-  298 (37.22/ 9.39)	AVTHLRFlarDMSEQVLLcaSSQTSSIVECWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.52|      32|      33|     731|     762|       3
---------------------------------------------------------------------------
  696-  724 (49.17/23.97)	EPD.ETL....LDECCLLPSQL.LPPRLDWLPVSD
  731-  762 (55.31/27.87)	QPK.QPL.RLRFGQAPALPSSA.TALQLDGLLRAP
  764-  798 (45.04/21.35)	QPKiDHLrRLHLGAYPTEECKAcTRCGCVTMLRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.49|      36|     370|     146|     183|       4
---------------------------------------------------------------------------
  146-  183 (56.17/45.11)	KFSRVKFSP.SLTLFGGKPMEGWIaVTVSGLVTvSLLRP
  518-  554 (58.32/37.60)	KASLCKLSPcTLTRVCDYHAKLFL.IAVSSTLK.SLLRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.41|      33|     316|      33|      69|       5
---------------------------------------------------------------------------
   33-   69 (52.02/56.29)	IAFT.TDLR..NDEQdLTRTIHILDTEHPWDVHSIpseHR
  349-  384 (50.39/38.43)	ISLTnTDLKvaNDTQ.FYPGLGLALAFHDGSVHIV...HR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11715 with Med16 domain of Kingdom Metazoa
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