<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11708
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MAAPSSGEKEKERSGGGATAAAAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQSGEENQVLELLIHRDEEFQELMKLALNQGKIHHEMQVLEKEVEKRDNDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPEVLAPQYPWQSNDMAMNMLPPNHSNDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 272 |
Position | Middle |
Organism | Erinaceus europaeus (Western European hedgehog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae>
Erinaceus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.672 |
Instability index | 52.20 |
Isoelectric point | 4.98 |
Molecular weight | 29957.22 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP11708
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 115.17| 29| 29| 55| 83| 1
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30- 51 (25.70/15.38) .ERLLSALED...LEVL....SRELIEMLA
55- 83 (49.38/36.05) NQKLLQSGEENQVLELLI.HRDEEFQELMK
87- 114 (40.09/27.94) NQGKIH..HEMQVLEKEVeKRDNDIQQLQK
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