<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11706

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMAPVQLENHQLVPPGSGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFSSRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKIGTASVHKVTIKIDENDGSKPLQIFHDPPLPASDSKLVERAMKINHLSIEKLLIDSVHARAHQKLQELKVILKGFNANENSSIETALPALVVPILEPCANSECLHIFVDLHSGLFQLMLYGLDQPTLDDMEKSVNDDIKRIILWIQQLKFWLGQQRCKQSIKHLPTICTESLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPDKPTQLSYKYYFMSVSTGDREDSPLTALLLQQFKEDIHDLVPHAKPGKQPRTGTKRKMSEDSCPVEPKKTKRSGETCAFNKVLAHFVAMCDTNMPFVGLRMELTNMEIPHQGLQMEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGSTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGTWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKASVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.06
Grand average of hydropathy-0.185
Instability index53.94
Isoelectric point8.89
Molecular weight160596.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     145.32|      24|      24|    1363|    1386|       1
---------------------------------------------------------------------------
  990- 1020 (30.79/11.05)	GDMmdslisqlqPPPQQQP..FPKQPGSSGA.YP..
 1069- 1087 (22.66/ 6.15)	............PPPSSHG..ISIGPGASFA.SP..
 1338- 1364 (28.84/ 9.88)	FCL.........TIPPSAPpiAPPGTPAVVLkSKML
 1365- 1388 (36.30/14.38)	FFL.........QLTQKAS..VPPQEPVSII.VPII
 1389- 1412 (26.73/ 8.60)	YDM.......asGTTQQAD..IPRQQNSSVA.AP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     246|     275|       2
---------------------------------------------------------------------------
  246-  275 (48.89/31.68)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/29.19)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.50|      55|     149|     340|     395|       3
---------------------------------------------------------------------------
  326-  384 (91.63/65.64)	VERYHAGKCL.slsvWNQQVLGRKIGTASVHKVTIK.IDENDGSK...PLQIFHDPPL.PASDSK
  386-  450 (70.87/44.33)	VERAMKINHLsieklLIDSVHARAHQKLQELKVILKgFNANENSSietALPALVVPILePCANSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     228.08|      31|      32|    1101|    1131|       4
---------------------------------------------------------------------------
   13-   39 (40.40/15.48)	.P......PGSGGGGSSG.P.ASAPAPPP..PGAAVAA
 1035- 1064 (45.22/18.28)	SP......SMMHTQSPGNlHAASSPSGALRAP..SPAS
 1101- 1131 (61.36/27.69)	SP......SGRAGTWPGS.PQVSGPSPATRMPGMSPAN
 1136- 1171 (46.83/19.22)	SPvpdashSPRAGTSSQT.MPTNMPPP.RKLPQRSWAA
 1187- 1212 (34.27/11.91)	LP......SPTPGLVPGL.AGSYLCSPLERFLG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.40|      32|      32|      66|      97|       5
---------------------------------------------------------------------------
   66-   97 (51.49/43.44)	LMVLTDLLPRKSDVERKIEIVQFSSRTRQLFV
   99-  130 (52.91/44.89)	LLALVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      38|    1247|    1261|       6
---------------------------------------------------------------------------
 1247- 1261 (21.47/19.10)	LKCRVALSP.KTNqTL
 1285- 1299 (22.14/13.48)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.87|      26|      32|     511|     540|       9
---------------------------------------------------------------------------
  511-  540 (40.29/35.76)	HLPT..ICTESLQLSNYSTHpignLSKNKLFI
  544-  571 (42.59/26.23)	RLPQyyIVVEMLEVPDKPTQ....LSYKYYFM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11706 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGTWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLENHQLVPPGSGGGGSSGPASAPAPPPP
970
4
1170
33










Molecular Recognition Features






MoRF SequenceStartStop




NANANA