<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11690

Description mediator of RNA polymerase II transcription subunit 12
SequenceMHRYHAGSCTSAVNNSNLGGPSSRDTGRSDSSFPAHFPVNSRRQPPLNPYKLKCDKEPLNSRLGAPDFHPQTTNCPEETLTREYLQSGYRDTVEGLEEAREISLTQVPHFNKTVVHNCKEAIKKRLRAINESRAQKRKAGQLYGVPLSGLQLAKPGIFPELRPCGEDFRKKWIEGLSQPHKRLRTLADHVPHGYKRSSLLAVLIRNNVPLLRATWFVKVTYLNQFRPGSAGVSSVTADKIQLSRTEIWTKDVIHYLQSLLDEFFSKNTSHSALHNRERSPQMPYAGTLIHKSDPFLSFSGGEESSLHFKWWYIVRLLQWHHAEGLILPSLVLDWVLNQLQEKDLLEVWQLLLPIVYGFLEIVVLSQTYVRTLAGIALRVIRDPAPGGSDLVDNSRRAYTTYALIEMLQYLILAVPDTFVALDCFPLPSSVVLHTMNDGNFVLKSTEAAGKIKNSSDDFGRIISCIQKRAEDLAKAASPGHPGHCLAKVAKALDNSLMLGDLHEAYKFLFEDFCDGTVSEGWIAKVSPCLRLSLKWFGTVDTSLIYSVFFLCEWATCGFRDFSTTLPCDIKFSGRKDLSQVHIAVRLLKMKLRDMKTSPRQTNESIRRASYIAKYGSQRHNRNYGANESKLKYNHTYGSSVISESPGPLHDIIVCWIDQHVVHKGEGLKRLHLFIVELIRAGIFFPLAYVRQLIVSGIMDTDVNVVDLERQKRHYHILKQLPGHFMRDALSESGIADGLQLVEALQIFLTERRLILRGSLSERHDGAASAKKSTLKRKQYPGSSKDGTSKSAKDGASIEELKEAISVLLQLPNSLTNLNSTGSDESEGSIRRPTLPRYGKIDPVVEATPGCEECRRAKRQKLSEERSSVVPGRSQLISDDYDTWWVKKGLKPTEPVKVDQPQKSTKQVTKTRQKNVRKMSLAQLAASRIEGSQGASTSHVCDNKVSCPHHRNAIDGDASRSGDSIRTSRDIVFIGKTLKRLRFVEKRVVAAWLLTVVKQVIEENEKNIGKVGQFGRAYSMVDDRSSIRWKLGEDELSTILYLIDISDDLVSAVRFLLWLMPKVLTTPNSTIHSGRNALMVPRNVENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMRRAATIIASNGRVSNSGATAFTRYLLKKYSNVASVIEWEKTFKSTCDARLSSEIESFRSVDGELGLPLGVPAGVDDPDDFFRQKISGSRLPSRVGVGMRDIVQRNVEEAFQYLFGKDRKLFAAGTPKGLALEKWDNGYQIAQQIVMGLMECIRQTGGAAQEGDPSLVASAVSAIVGSVGPTLAKMPDFSSAINHSSIMSATSSLNYARSILRMYITCLCLLKEALGERQSRVFDIALATEASNVFAGVFAPTKASRAQFQMSSEVHDTSGISNDVGNNSIKTVVTKTTKIAAAVSALVVGAVIYGVTSLERMVTILRLKEGLDVIQCIRTTRSNSNGNARSVGAFKADNSIEVHVHWFRLLVGNCRTLCEGLVVDLLGEPSIVALSRMQRMLPLSLVFPPAYSIFAFLRWRPFILNANVAVREDTNQLYQSLTMAVADAIKHLPFRDVCFRDCQGLYDLMAADGSDAEFAAMLQLNSSDMHLKSMAFVPLRSRLFLNAMIDCKMPPPIFTKDDVNRVSGPGESKIKFANGDSKLQDKLVHVLDTLQPAKFHWQWVALRLLLNEQALIEKLETHDVSLSDAILLSSPSPEKVAAASENESNFIEILLTRLLVRPDAAPLFSELVHLFGRSLQDSMLLQAKWFLEGQDVLFGRKTIRQRLHNIAESRGLSVKTQYWEPWGWCSQSADPVTTKGDKKKFDITSLEEGEVAVDEGIDLKRSLKGLSQVFDSESSRINQQHVTEKALIELLLPCMDQSSEESRNTFANCLMKQLSNIELQISAVTGGSKPVGSNPPGVEGQTTKVNTRKSLRGGSPGLARRPTVVTDSSPPSPAALRVSMSLRLQLLMRFFPILCADREPSVRNMRHFLAPVILRLLGSRVVHEDANILTNAVHSKKDLESSSEAASAAFVDFSAEGLFDRLLLVLHGLLSSYPPSWLRLKPVSKSINEPMKESSGFDRELLESLQNDMDRMQVPDTIRWRIQAAMPVLFPSIRCSFSCQPPPVSISALVSVPGFNSSSSANPPRNPVLSRVAANASSGKSKQQDSELEIIDPWTLLEDGAGSCPSASNTASIGGGDHANIRAASWLKGAVRVRRTDLTYVGAVDDDS
Length2223
PositionKinase
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index50.96
Isoelectric point9.00
Molecular weight246365.31
Publications
PubMed=26259924

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11690
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.53|      24|      34|    1682|    1705|       1
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 1682- 1705 (38.66/25.79)	NEQALIEKLETHDVSLSDAILLSS
 1717- 1740 (40.87/27.72)	NESNFIEILLTRLLVRPDAAPLFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.42|      15|      35|     685|     699|       2
---------------------------------------------------------------------------
  685-  699 (27.44/17.31)	PLAYVRQ.LIVSGIMD
  721-  736 (22.97/13.18)	PGHFMRDaLSESGIAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.54|      23|      26|    1841|    1865|       3
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 1841- 1865 (33.51/27.16)	LSQvfDSESSRINQQHVTEKAL..IEL
 1870- 1894 (36.04/22.10)	MDQ..SSEESRNTFANCLMKQLsnIEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.67|      15|      30|    1532|    1550|       4
---------------------------------------------------------------------------
 1532- 1550 (18.50/25.81)	PFilnANVAVReDTNQLYQ
 1564- 1578 (32.17/23.20)	PF...RDVCFR.DCQGLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.32|      28|      35|     550|     581|       6
---------------------------------------------------------------------------
  550-  581 (45.64/37.65)	LCEWAtcgFRDFSTTlPCDIKFSGR......KDLSQVH
  586-  619 (40.67/21.34)	LLKMK...LRDMKTS.PRQTNESIRrasyiaKYGSQRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.97|      32|      35|    1908|    1939|       7
---------------------------------------------------------------------------
 1908- 1939 (57.61/33.90)	SNPPGVEGQTTKVNTR.KSLRGGSPGLA..RRPTV
 1943- 1977 (47.37/26.43)	SSPPSPAALRVSMSLRlQLLMRFFPILCadREPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.22|      12|      35|     485|     496|       8
---------------------------------------------------------------------------
  485-  496 (19.02/ 9.24)	LAKVAKALDNSL
  522-  533 (21.21/11.14)	IAKVSPCLRLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     345.95|     113|     666|     214|     350|       9
---------------------------------------------------------------------------
   89-  206 (179.02/145.28)	YRDTVEGLE..EAREISLTQVPHFNKTVVHNCKEAIKKRL.RAINESRAQKR.KAGQLygvPLSGLQLAKPGIFPELRPcGED..FRKKW..IEGLSQPHKR....LRTLA.DHVPHGYKRSSLLAVLiRN
  225-  350 (166.92/162.90)	FRPGSAGVSsvTADKIQLSRTEIWTKDVIHYLQSLLDEFFsKNTSHSALHNReRSPQM...PYAGTLIHKSDPFLSFSG.GEEssLHFKWwyIVRLLQWHHAegliLPSLVlDWVLNQLQEKDLLEVW.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.10|      24|      35|     968|     991|      15
---------------------------------------------------------------------------
  968-  991 (39.09/26.46)	RDIVFIGKTLKRLRFVEKRVVAAW
 1005- 1028 (42.01/29.05)	KNIGKVGQFGRAYSMVDDRSSIRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.97|      35|      40|    1408|    1447|      16
---------------------------------------------------------------------------
 1408- 1447 (47.02/45.81)	TKIAAAVSALVVGAvIYGVTSLERMVTILRLKEGldviQC
 1451- 1485 (62.95/43.95)	TRSNSNGNARSVGA.FKADNSIEVHVHWFRLLVG....NC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11690 with Med12 domain of Kingdom Viridiplantae
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