<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11670

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQITWFQFLPHEPDLNPLPDKSLKSDQKDAAMLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSVSETAQPALSGLRVVASGLWVAPGDSEEVASALSQALRNCIERALLGLYYMRFGDVFSKVHQFQSEELLRKGHPAFEFVFAATEEAIFIHVIVSSKNIRMLSTSDLEKLLKHSTEATYRLPVVVSPHGVRGSLTGCSSSDLVKQSYFSSAKFRVSNGIIGLPYHVSQGVGCQLRGQNCFVEVSLGFARSGTDKALQTNRNIVRNLPKSPVMGQSDHKGSPDHLLVNEKTFLYPAEAVLVPVFQTSLARSSLRRFWLQNWMGPSLTGSSSFIHCAGNVESTEDPWTEINGSRTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGLSELEADADSLTCRQSMVSSGRLGSDGSILGSKRSRTGVTQSLSMTTHIPGQDAYMSDFGSMEVNNSAITRVGNEPIGSIWDWDDEEDKGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALILSAPDCGDVNSSPAGASAMDVSDQMLLPIGFSSFESFDPTPPSVMEECLNKGQDNLSNSMQMGPTNQTQMMYTREYDHVMKAEAMMTFAQEFGAVEAPTSGLSTALFRSPYFPKSRKAESSNSCSNNYLYGAEPPSSPYIEGSEGKNGLVINTKTCSGKHDTSMTLHSKNYYTFVDSRKDINDKKPVTCIDNSIAKSEGIVQPPFSNIGSNASVKSVLRKMTGGTKEADHFVLSAKNLLATDVTCAMLQASMCRLRHTLLSSGNNLLSVGLSRSTGVTFSNQLPTDPSTTTDISGKYEVKKKENIPVRIAGDIDGGMLDGHLNAPVGVWRSVGASKVVKPSNSPNIDVGSSFSHNSFNEESLLSYGQRKPLQELLDGIALLVQQATSFVDLALDADCGDGPYGLLAMQEQWRRGFCCGPSMVHAGCGGTLASSHSLDIAGLELVDPLSSDVHASTVISLLQSDIKTALKSAFSNLEGPLSVTDWCKGRNQLVDTGSIVDGVSAESSISECRDSSEPMSPSQSSVCGSSSIKVSSIMDNAKVDETSQRRSGQDSESEQHPSSRLKPTLIAVPLPSILVGYQDDWLKASANCLQHWEKAPLEPYALQKPITYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHLPLGLGNQMEIEPAKSSTCGFVLLDCPQSMKIESSNASLVGSVSDYFLSLSNGWDLTSYLKSLSKALRALNLSSCFSANPTEGSNSSSLVIYVVCPFPDPTAILQTVIESSVAIGSVIQQSDRERRSSLHSQVVKALSGWATVDEASASNILVLSGCSIPKLVLQIVTVDAIFRVTSPSVSELVILKETAFTVYNKARRISRGISSDLAQLAFSSRSQSALAQMPSPISGMWKDCVGPRMVGHSLPRESDIDASLRPGNWDNSWQPARSGVLNCDPSRTGDIFLHDEIRYMFEPLFILAEPGSPEHGISVISSPSSEASKALADDSSGNHGQSTNTAGNVDSASSIDGSGSDQKTHPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQVLQQGCLILQSCDPGLAKPRDFMIARIGGFYELEYLEWQKAIYSVGGSEMKRWPLQLRKSLSDGASSTSNGSSLQQTDMSLIPERTLPSSPSPLYSPHAKQTGFIKGSLDGQPAARKQLMSGHSMVDSSRGLLHWAQSISFVAVSMDHTLQLVLPADSSSPGYVEGFTPVKSLGSASSAYILIPSPSMRSLPPTALQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLSVSLIDYYGGSNIPQEKIVRGVNKQGGRGLSWDAKDFETETHLILESLAAELHALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKELSKQSEKS
Length1949
PositionKinase
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.07
Grand average of hydropathy-0.224
Instability index53.51
Isoelectric point5.55
Molecular weight210955.27
Publications
PubMed=26259924

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11670
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.87|      26|      54|     425|     478|       1
---------------------------------------------------------------------------
  425-  450 (45.24/32.17)	DADSLTCRQSMVSSGRLGSD..GSILGS
  480-  498 (12.14/14.21)	....MEVNNSAIT..RVGNEpiGSI...
 1514- 1539 (44.50/ 8.26)	DDSSGNHGQSTNTAGNVDSA..SSIDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.20|      32|      54|     511|     542|       2
---------------------------------------------------------------------------
  511-  542 (63.23/44.93)	MDI..QALLS.EFGDF....GDFFE....NDVLPFG.......EPPGTAE
  566-  593 (38.82/23.93)	MDVsdQMLLPiGFSSF....ESF.......D..P.........TPPSVME
 1163- 1203 (19.15/ 7.01)	.DI..DPLTS.AAADFfqqlGTVYEtcklGTHLPLGlgnqmeiEP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.50|      25|      54|     711|     736|       3
---------------------------------------------------------------------------
  711-  736 (42.39/38.70)	MTLHSKNYYTFVDSRKDInDKKPVTC
  768-  792 (44.11/34.21)	MTGGTKEADHFVLSAKNL.LATDVTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.79|      35|      57|       2|      58|       4
---------------------------------------------------------------------------
    2-   43 (53.84/47.55)	WTNVFkIGGlhqitW..FQFLpHEPDLNP.....LPDK.SLKSDQKDAAM
   62-  104 (52.95/48.88)	WTNSF.VGP.....WdpSQGL.HNPDEKIklwlfLPGRhSSVSETAQPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.84|      27|      57|     816|     844|       5
---------------------------------------------------------------------------
  816-  844 (42.87/33.13)	VGLSRSTGVtfSNQLPTDPSTTTDISGKY
  873-  899 (45.97/28.46)	VGVWRSVGA..SKVVKPSNSPNIDVGSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.33|      33|     127|    1304|    1342|      14
---------------------------------------------------------------------------
 1305- 1338 (53.12/43.49)	GSVIQQSDR....ERR.....SSLHSQVVKAlSGW..ATVDEASA
 1670- 1713 (45.21/18.67)	GSSLQQTDMslipERTlpsspSPLYSPHAKQ.TGFikGSLDGQPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.66|      63|     826|     981|    1048|      15
---------------------------------------------------------------------------
  981- 1048 (91.42/67.43)	HSLDIAGLELvdPLSSDVHASTVISLLQSDIKTALKSAFSNLEGpLSVTDWCKGRNqlVDTGSIVDGV
 1810- 1872 (109.23/63.71)	HLLHSKGSAL..PLSTGFVVSKAVPSMRKDYRSNLKEEWPSVLS.VSLIDYYGGSN..IPQEKIVRGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.93|      27|     630|     397|     423|      16
---------------------------------------------------------------------------
  397-  423 (44.77/25.21)	SNSSSI..SSL..SASS...SDSDYKTTGL.SELE
 1049- 1073 (26.55/11.23)	SAESSI..SEC..RDSSepmSPSQSSVCG......
 1074- 1103 (20.61/ 6.67)	..SSSIkvSSImdNAKV...DETSQRRSGQdSESE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.45|      10|      14|     617|     626|      17
---------------------------------------------------------------------------
  617-  626 (19.79/12.79)	MMYTREYDHV
  633-  642 (17.66/10.64)	MTFAQEFGAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.97|      20|     630|     943|     964|      18
---------------------------------------------------------------------------
  943-  963 (37.75/23.19)	DCGDGPYGLLAmQEQWRRGFC
 1575- 1594 (37.22/17.54)	DCNIFPFGGIS.SRQDTKGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.23|      15|      28|     180|     194|      22
---------------------------------------------------------------------------
  180-  194 (25.41/17.66)	EAIF.IHVIVSSKNIR
  210-  225 (22.82/14.99)	EATYrLPVVVSPHGVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11670 with Med13 domain of Kingdom Viridiplantae
Unable to open file!