<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11655

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMATAELGQQTVELSTLVTRTAQDSYNSLKELVDKCRSIELSDTDKKISMLKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAVEILLSGSYQRLPKCIEDVGSQYALTEDKQKPALNKLDTLVRSKLLEVSLPKEISDIQVSDGTAMVRVDGEFQVLLTLGYRGHMSLWRILHLELLVGEKNKPVKLEELRRHVLGDDLERRMAATENPFSILYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELITEGGSGHGASSSSLQNPDGESDSSGLRTPGLKIVYWLDFDKNAGMSDSGVCPFIKVEPGSDLQIKCTHSNFVIDPLTGKEAEFFLDQNCIDVEGLLLMAIRCNRYTRLLEIKRELIKNVQVCRTADDVVLQSRMGEPDIEHKQDDKCCNKELDGHEVLRVRAYGSSFCTLGISIRNGRFLLQSSQNIVVSSALLECEEALNQGSMTAAEVFLSLRSKSILHLFASIGRVLGLEVYEHGLNTVKIPKTFLNSSAMLMMGFPDCGSSYFLLMQLDKDFKPLFKLLETHPDPSGKDNLFGDLNQVLRFKKIDIAQMQVLEDEMNLSLVDWGKLRTILPNVSCSNQILGHELYSDTGLESSIHISRGHHPSGFSSLVDEVFGLEIGSSVPPFPIQNLASPSNTSLPSHYGSVPMNSHSLKAGIPSPKWEGGMQISQVNNVTTLYNGSMFSSGGVKGPVQSSSVGSIPTGQGRSTVGKKLSASKSEQDLASVKSPHSVDISSSTPMDEDTANDALSGSRSSLLSPPRPTNSRLSAPSSRPNGPLVESFKAAGSSSCATTPVSQGLECTVAFGTSEDVISEHDKKSRKRTASDMLNLIPSLQGVLKNQGNCKRRKISDSCGSQLSLPPGTFSSEMIPKAEGCSYGSLIAEANKGNAPTSVYVAALLHVVRHSSLCLKHARLTSQMDALEISYVEEVGYRSASSNIWFRLPFARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSSNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEEDSIKKLVADIQRLANARTFSIGMRKLLGTRADERSEELITSSDAKISGAKTASDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESSKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAAPFPKQAGYISSQGLLLGSSTANVGQPASGSGANTVMSNASGITNQTLSMLAAAGRGGPGIVPSSLLPFDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLTNSNNPNPNSGAQLMAANGNRLNSAAMSRTGNQAASLNRMGNALAGSSNLALMTSAVSLRRPPGTVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPIPEELSPSEISEICDYFSRRVASEPYDASRVASFITMLTLPIPVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHAGLNGDENSESSSAFRSNIHYDRLHNSVDFALTIVLDSAHIPHVNAAGGAAWLPYCVSVRLRYSFGESLNVSFLGMNGSHGGRACWSRVDDWEKCKQRVARTVEVNASSAADVSQGRLKLVADSVQRNLQMCIQGLRDGSGVTASSGAT
Length1798
PositionTail
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.06
Grand average of hydropathy-0.177
Instability index44.92
Isoelectric point6.91
Molecular weight195754.68
Publications
PubMed=26259924

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11655
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      13|      17|    1391|    1405|       1
---------------------------------------------------------------------------
 1391- 1405 (18.60/15.82)	GAQlmAANGNRLNSA
 1411- 1423 (24.23/13.32)	GNQ..AASLNRMGNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.07|      63|     259|     607|     724|       2
---------------------------------------------------------------------------
  607-  699 (86.69/120.16)	EMNLSLvdwgklrtilpnvscsnqilghelYSDTGLESSIHISR.GHHPSGFSSlvdEVFGLEIGSSVPPFPIQNLASPSNTSLPShygSVPMN
  727-  790 (102.38/43.94)	LYNGSM........................FSSGGVKGPVQSSSvGSIPTGQGR...STVGKKLSASKSEQDLASVKSPHSVDISS...STPMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.99|      33|     259|    1348|    1386|       3
---------------------------------------------------------------------------
 1348- 1386 (48.83/52.34)	LPCPQFRPFiMEHVAQElNGLDPSftgqQAGGLTNSNNP
 1608- 1640 (57.16/38.19)	LPIPVLREF.LKLIAWK.KGLSQA....QVGDVVSAQKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.70|      16|     259|    1451|    1470|       4
---------------------------------------------------------------------------
 1432- 1447 (26.80/16.10)	LMTSAVSLRRPPGTVV
 1455- 1470 (27.90/10.62)	LNTAIIGLGDDGGYGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.95|      31|     301|     193|     225|       6
---------------------------------------------------------------------------
  193-  225 (51.68/40.90)	QVLLTLGYRG..HM..SLWRILHLEllVGEKN.KPVKL
  497-  532 (39.27/24.14)	EVFLSLRSKSilHLfaSIGRVLGLE..VYEHGlNTVKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.20|      24|     117|    1202|    1226|       9
---------------------------------------------------------------------------
 1202- 1226 (38.51/27.68)	IRLTAGPLHALAAATrPARAGPVPG
 1322- 1345 (47.69/29.99)	MRCFAGDQVWLQPAT.PPKEGRLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.95|      22|     404|     138|     159|      10
---------------------------------------------------------------------------
  138-  159 (39.48/25.69)	DVGSQYALTE..DKQ.KPALNKLDT
  549-  573 (32.47/19.79)	DCGSSYFLLMqlDKDfKPLFKLLET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11655 with Med14 domain of Kingdom Viridiplantae
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