<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11641

Description mediator of RNA polymerase II transcription subunit 15a
SequenceMDSNNWRPNQGAEPNMDSSDWRGQLQPESRQRVVNKIMDTLKRHLPVSGQEGLLELRKIAQRFEEKIFTAATSQPDYLRKISLKMLTMETKSQGTMANNIPSNQGGPSNKPPDPGLVMQSQVHNQGQQHPIPLSNQPQSRQQLLSQNIQSNMASQPNLPSVSGLAQTPIPNVGQNSNIQNMFNGSQRQMQGRQQVVPQQQQQQQSQNSQQYLYQQQLIRHKLQMQSQQQQQQQHQQQQQQQQQQQQHQQQQQQQQQQQQQQNLLQSNQLQSSQQSVMQQPSMMQTSSLSSIQHNQQSNNGQQSAQSMLQQHPQVIRQQQQQQTSIIHQQQTPMAQQSILPPQQQPQQQLMGQQANATNMQHTQMLGSQNNVGDLQQSQRLLAQQNNLSNLQQQQLINQQNNLSNIHQQLGNNVPGLQPQQVLGSQSGNSGMQTSQHSAHVLQQSKVPIQQQSQQGASNLLPSQAQQSQPQAPQQQLMPQIQSQPAQLQQQLGLQQQPNPLQRDMQQRLQASGSLLQHSGVLEQQKQLYQSQRPLPETSSNSMDSTAQTGQPSGGDWQEEVYQKIKAMKESYLPELSEMYQKIAAKLQQHDSLPHQPKSDQLEKLKVFKLMLERLITFLQVSKSNISPSLKEKLGSYEKQIINFINTNRPRKMSSLQPGQLPPPHMHSMSQTQSQVTQVQSHENQMNTQLQTTNMQGPVATMQQNNMTSMQHNSLSGLSTTQQNMMNTMQSSANLDSAQGNMNSLQQVPVSSLQQNPVTAPQQTNASSLSSQAGVNVIQPNLQPGSSMLQHQQLKQQQEQQMLQNQQFKQQYQRQLMQRQQMLQQQQQLHQPAKQQLPAQLQTHQMQQLHQMNDVNDMKMRHGIGGKPGVFQQHLASSQRSTYPHQQMKQGPFPVSSPQLLQATSPQIPQHSSPQVDQHNHLPSLTKVGTPLQSANSPFVVPTPSPPLAPSPMPGDSEKPISGVSLISNAANVGHQQTGGAAAPAQSLAIGTPGISASPLLAEFTGPDGAHGNALVPSSGKSTVTEEPLDRLIKAVNSLTPAALSAAVSDISSVVSMNDRIAGSAPGNGSRAAVGEDLVAMTNCRLQARNFITQDGANGTRRMKRCTNATPLNVVSSAGSVNDSFKQLTAMEASDLESTATSNIKKPRFEANHALLEEIREVNQRLIDTVVSISDEEVDPTAAAAAAEGAEGTIVKCSFIAVALSPSLKSLYASAQMSPIQPLRLLVPTNYPNCSPIFLDKFPVESSMENEDLSAKAKSKFSISLRGLSQTMSLKEIAKTWDVCARTVISEYAQQSGGGTFSSKYGSWEDCSTW
Length1313
PositionTail
OrganismCicer arietinum (Chickpea) (Garbanzo)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Cicereae> Cicer.
Aromaticity0.03
Grand average of hydropathy-0.825
Instability index72.33
Isoelectric point9.19
Molecular weight145120.44
Publications
PubMed=26259924

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11641
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     466.08|      56|      56|     352|     407|       2
---------------------------------------------------------------------------
  174-  248 (50.23/ 8.38)	Q.NSN.IQNMfngSQRQMQ..GRQQVVPQQQQQQQ.....SQ......NSQQYL..YQQQLIR..HKLQMqSqqqqqqqhqqqqqqqqqqQQHQ
  251-  301 (58.22/11.40)	Q.QQQ.QQQQ...QQQNLL..QSN....QLQSSQQ..SVMQQpsmmqtSSLSSI..QH....N..QQ....S..................NNGQ
  302-  351 (59.90/12.04)	Q.SAQ.SMLQ...QHPQVIrqQQQQQTSIIHQQQT..PMAQQ......SILPPQ..QQPQ.....QQ........................LMG
  352-  407 (94.54/25.17)	Q.QAN.ATNM...QHTQML..GSQNNVGDLQQSQR..LLAQQ......NNLSNL..QQQQLIN..QQNNL.S..................NIHQ
  408-  454 (47.44/ 7.32)	QlGNN.VPGL...QPQQVL..GSQSGNSGMQTSQHsaHVLQQ......SKVP.I..QQQ...S..QQ...........................
  495-  539 (53.41/ 9.58)	Q.QPN.PLQR...DMQQRL....QAS.GSLLQHSG..VLE................QQKQLYQ..SQRPL.P..................ETSS
  681-  736 (51.31/ 8.78)	H.ENQmNTQL...QTTNMQ..GP...VATMQQNNM..TSMQH......NSLSGLstTQQNMMN..TMQSS.A..................NLDS
  803-  850 (51.02/ 8.67)	.............QNQQF....KQQYQRQLMQRQQ..MLQQQ......QQLHQP..AKQQLPAqlQTHQM.Q..................QLHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.44|      15|      17|     559|     573|       5
---------------------------------------------------------------------------
  559-  573 (26.83/18.59)	EVYQKI..KAMKESYLP
  577-  593 (22.61/14.33)	EMYQKIaaKLQQHDSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.30|      21|     109|      26|      49|       6
---------------------------------------------------------------------------
   26-   46 (35.53/10.44)	QPESRQRVVNK.IMDTL..KRHLP
  136-  159 (31.77/15.00)	QPQSRQQLLSQnIQSNMasQPNLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.24|      23|      26|     977|     999|       7
---------------------------------------------------------------------------
  943-  960 (30.81/13.20)	PS..PPLAPS.....PMPGDSEKPI
  977-  999 (38.69/18.53)	TG..GAAAPAQSLAIGTPGISASPL
 1004- 1028 (29.75/12.48)	TGpdGAHGNALVPSSGKSTVTEEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.14|      16|      21|    1089|    1108|       8
---------------------------------------------------------------------------
 1089- 1106 (25.05/28.07)	NFITQDGA.NGTrrMKRCT
 1112- 1128 (22.09/ 8.53)	NVVSSAGSvNDS..FKQLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.37|      21|     113|    1130|    1171|       9
---------------------------------------------------------------------------
 1130- 1150 (34.17/65.40)	MEASDLESTATSNIKKPRFEA
 1180- 1200 (33.20/13.32)	TAAAAAAEGAEGTIVKCSFIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.67|      25|     125|     644|     672|      10
---------------------------------------------------------------------------
   96-  125 (34.16/14.47)	MANNIP....SNQGGpsNKPPdPGlvMQSQVHNQ
  644-  672 (45.50/31.36)	INTNRPrkmsSLQPG..QLPP.PH..MHSMSQTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.40|      15|     441|     466|     488|      11
---------------------------------------------------------------------------
  461-  483 (17.34/17.05)	PSQAQqsqpqapQQQLMPQiQSQ
  785-  799 (26.06/ 6.13)	SSMLQ.......HQQLKQQ.QEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.16|      19|      27|    1035|    1060|      15
---------------------------------------------------------------------------
 1040- 1060 (28.15/26.72)	PAALS.AAVSDisSVVSM.NDRI
 1065- 1085 (27.01/ 9.07)	PGNGSrAAVGE..DLVAMtNCRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11641 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDSNNWRPNQGAEPNMDSSDWRGQLQPESRQRVVNKIMDTLKRHLPVSGQEGLLEL
2) NLSNLQQQQLINQQNNLSNIHQQLGNNVPGLQPQQVLGSQSGNSGMQTSQHSAHVLQQSKVPIQQQSQQGASNLLPSQAQQSQPQAPQQQLMPQIQSQPAQLQQQLGLQQQPNPLQRDMQQRLQASGSLLQ
3) QIINFINTNRPRKMSSLQPGQLPPPHMHSMSQTQSQVTQVQSHENQMNTQLQTTNMQGPVATMQQNNMTSMQHNSLSGLSTTQQNMMNTMQSSANLDSAQGNMNSLQQVPVSSLQQNPVTAPQQTNASSLSSQAGVNVIQPNLQPGSSMLQHQQLKQQQEQQMLQNQQFKQQYQRQLMQRQQMLQQQQQLHQPAKQQLPAQLQTHQMQQLHQMNDVNDMKMRHGIGGKPGVFQQHLASSQRSTYPHQQMKQGPFPVSSPQLLQATSPQIPQHSSPQVDQHNHLPSLTKVGTPLQSANSPFVVPTPSPPLAPSPMPGDSEKPISGVSLISNAANVGHQQTGGAAAPAQSLA
4) QKQLYQSQRPLPETSSNSMDSTAQTGQPSGGDWQEEV
5) QMQSQQQQQQQHQQQQQQQQQQQQHQQQQQQQQQQ
6) QQNLLQSNQLQSSQQSVMQQPSMMQTSSLSSIQHNQQSNNGQQSAQSMLQQHPQVIRQQQQQQTSIIHQQQTPMAQQSILPPQQQPQQQLMGQQANATNMQHTQMLGSQNNVGDLQQSQRLLAQQ
7) RKISLKMLTMETKSQGTMANNIPSNQGGPSNKPPDPGLVMQSQVHNQGQQHPIPLSNQPQSRQQLLSQNIQSNMASQPNLPSVSGLAQTPIPNVGQNSNIQNMFNGSQRQMQGRQQVVPQQQQQ
1
386
639
524
223
260
79
56
516
988
560
257
384
202










Molecular Recognition Features






MoRF SequenceStartStop




1) LIRHKLQM
217
224