<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11630

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSQIYWRIYTEEPNSANNPGESPANGYTILKHLSRLKDLELQIRDRDCLVSSYPRRLCLWVFSATPGFESLLPLSANEAKDDSSRLAIGSATMKVSSLGNVSSLDLVKNLSAEPQNAPGTTGPQRQNALTPYATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTAVERDSYDRFVKNDPLSASSLTTLQIQLTSVGKLTVALQTVSQAGLMRLLAPEDDPAGIHDTPPGTDLWLSPSGSIARLVAASPSRLNAASPYPSSAGGPGNDKSSMANRKQWKVNVLWWLANFGLPVDEVDEEAWVEVEVWEPFYSRLAGEIGRSNDESSSTLPLKRILWPAIYCFKRTKSASSDSHGELDSVGPVLGDPLDFAEKWRVTEKPTFIEASPKPPSVHQDLQARDQDASSPDMPNLPEGIESLSRASQYPELQTASLVYPTPPDGAAATGLNPTVPSDVSPDDLEQGSSFMQPSRQSFQGQLSKDRTGAEVITFGPSAGLVVGSGLYDTNDDDDLFGDINERDFGSKGLTDADFSFFDDPDFDHVGGGEQEVPIHAMSDFMDTDEPELQPTADDHASPEQTPAGDIDSSRLSSVVETAELEQEKSIPEEKTPVSSPRDDKPRTISPPLSPVEVKKILFPEPQVGSQHLIKQGQMPGYYNAVAFKQNMSLWDRKYSAEGKFGFTFRGMEGPKGANAATSDIPTIGLPRRSGKLKSGTSKEPGSHASPTSGMQASSSDTDSSSDTSIESDESGSEGGLSPATFPTRKRKRTRSNSGTSLALSQEKAFLRADQETTPQRPEDSVFLGNFLSTFSDWSMAGYFSLAQSQVSPVLVRKDIEVQIAQLLVDQVTQSSLDHKIDGTLGLSDYDDEAYSLQTQLGDAAFVGGMERLDLNSFVSLQDASTLSSPTSNGPNPRQSSQRKEAGKGTIMKIPPPHLRVCRGKEFLETLPPAISFWETFGLEPAHGQKDIFAYCIHPHFAAEAADAFLERLGLVYSGCNLGSHTRGERSNFFDRGLGSWDISPSEDSRYFEVMQSLKTICGVLGSAFLNTPPSKDSNLVVYIVNPFTHAAALVDICSAFWSLFQKYIADADRKQARQLNELVLQIIPIDFVTATGSLVVPPQADYLNLALEVYSRCPPKSTQPSLVNCAPPVLLAEPLPRSIGFKLSSEGSSPLQEGKCLHIACSRSLDQRWISVAWSDNFGALQRTMSYCLRFRNSLISRPLVEVRNEIWRATRDIMDRVQARWRVVIVNTDPVDQEEVDTWSSFADQYGKARSMTLDLVILNANTTPDLYLEPPFLPVPLSVFNQQSSSTPIATPNPGGSVSSPDQLGNAPTPPGGWGALANPSTPTDALPEIESDSLLTDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILFARRPPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAVKAQTMLSYAL
Length1482
PositionKinase
OrganismAspergillus carbonarius (strain ITEM 5010)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.370
Instability index52.37
Isoelectric point4.94
Molecular weight161395.49
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11630
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.77|      10|     127|     139|     148|       1
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  139-  148 (20.82/11.92)	PQRQNALTPY
  267-  276 (19.95/11.08)	PSRLNAASPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     671.83|     143|     147|     494|     637|       2
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  367-  468 (143.63/75.75)	SSDSHG.ELDSVGP....VLGDPL......................DF.AEKWRVTEKPTFIEaSP........KPPSV....................HQ....DLQ.........ARD....QDASSPD.mpNLPEG.IES..LSRASQYPEL.QTASLVYPTPPDGAAATG..LNPTVP
  495-  637 (236.84/135.91)	SKDRTGAEVITFGPSAGLVVGSGLYDTND...DDDLF.GDI..NERDF.GSKGLTDADFSFFD.DP........DFDHVGGGEQEVPIHAMSDFMD.TDEP....ELQ.........PTA....DDHASPE...QTPAGDIDSSRLSSVVETAELEQEKSIPEEKTPVSSPRDD..KPRTIS
  645-  783 (153.74/84.31)	..............VKKILFPEPQVGSQHlikQGQMP.GYY..NAVAFkQNMSLWDRKYSAEG.KF........GFTFRGMEGPKGANAATSDIPT.IGLPrrsgKLK.........SGTskepGSHASPTsgmQASSSDTDSSSDTS.IESDESGSEGGL....SPATFPTRK..RKRTRS
  785-  928 (137.60/74.52)	....SGTSLALSQEKAFLRADQETTPQRP...EDSVFlGNFlsTFSDW.SMAGY....FSLAQ.SQvspvlvrkDI........EVQIAQL..LVDqVTQS....SLDhkidgtlglSDY....DDEAYSL...QTQLGD...AAFVGGMERLDLNSFVSLQDAST.LSSPTSNgpNPRQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.75|      17|      33|    1082|    1098|       3
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 1082- 1098 (32.17/20.82)	VDICSAFWSLFQKYIAD
 1117- 1133 (29.58/18.50)	IDFVTATGSLVVPPQAD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.91|      23|     145|    1150|    1177|       6
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 1150- 1177 (30.01/31.79)	TQPSLVnCAPPVLlaePLPRSIgFKLSS
 1296- 1318 (44.90/25.83)	TTPDLY.LEPPFL...PVPLSV.FNQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.16|      15|      40|     944|     958|       7
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  944-  958 (27.96/20.21)	PHLRVCRGKEFLETL
  986- 1000 (26.20/18.43)	PHFAAEAADAFLERL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.84|      17|    1095|     238|     260|      11
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  238-  260 (26.08/25.68)	DPAGIHDTPPGTdlWlspsGSIA
 1336- 1352 (35.76/17.39)	DQLGNAPTPPGG..W....GALA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11630 with Med13 domain of Kingdom Fungi
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