<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11628

Description Uncharacterized protein
SequenceMIPHPSAGVQPWGRSVRALNNGSGRVDASQTLGQPDSQLEKLSMPMPQSLPRQPAVIDLTTNTSDSQEREPPAKRLKLDVPLGSCPAEGSPAPGSGGEARSTPGTASSKPNPLSWRGRPVWSFQALVSETSGATETKEDDATSQGKNPASPPPLPLVPWKYTPQESSGSNSAGPADIAPTKEVQTTPYRIVVPAVAPKVKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHNTVTAPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGALALGLETKWVRDWTSTVQQFLESVISTCGTPDWKMKMTYAVSLTSRLFFERLLDHDQYLAWFLLSLEAASLNTVPVWLLMLGIYWNNIMRYRKRGRRLAEVLLEKLRQIKQPAQHTALEPLVDRLSRCVRRLVLEHTSSVILPNSWEKYKDVVASCLNLNETPDKTTLQNLAERNARVQLPNSHQETAQRLPQQYIIHLFDSIRSAHDISATSSTCLGAVEDKASLVSKLLEWASTPFRHGSRRVYTSVRLLRKWKMSGMDVESHILAFLADVHITSRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPLPGEQQAISDDLRLLMQLPLARLPEYVRNLRNTLLSRTGMPASQEESVIAAVKASIAQRLPKIFGAQISDAMLTDLSLPSLTWAVKSEIGLWIRRGVSEHRRDPIRKYAHIPMLADSGVSALTPVEFYNIRDVLESFGDISMLADVLKQATNCEDSVVLASVADTVNYHFDSLCVIGAATDLFKGLVESYARLKRLGAPSLDLIFSLIELGLRMPSEFNTVALLRQDLSRIESKSALAAPSPLSDHIPMGFGEFDTSFQEKLDQILFSGGGMDESTMDAIFNSLTRALGTEHSPVKLPANDICRYMAYLRSFHPKRFDARLVRWVCGLLKSPSRSALVRILPPLIGVGCVTIHAFVMLVKKLLQSERVASVVPKVTDLRLDLLELLIPRGPTQGRYADMVTYRYYLAQQEFIDKHPEECLEIIRDAVPMVNTRPPGIAWVSNQTDLITCAMNLLQTLLTQKPERMVQCCMQKFIGQDLASTALLQKALDALLGFGSQDPQAMPEAERVIGMNNDFSLPLCQLKLQVLFNAEAGNGLDNGIVDVMFKAAMADARSKRSHWYGLVSLMSQDAVRQIRERAERGFFSVPMLEELISDPTVADKSNSIETARLYLTIVEKLAHSIPETGAHSVAPILVERMELLLQKFITMQSSLSGAVDASQTAQVRSNFERSLAFWFSALLRLVVIHRAAFNMPALAPRPNGLQEQSRILIAIFCISLARLPDRVIRLYPSANYFPHPVQSENYRPCPGILLQTHALDVAAALIDTFPDEARQQCARFLREKCPPFLQFQNDSRFLYLLGPMLDTSSSNPPQPASLPSPAAGGSTPTPTANLTGGPPNPQQTISSAPSGLPAGLSEGVNCIASHLRLQYRGRVIGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1586
PositionKinase
OrganismAspergillus carbonarius (strain ITEM 5010)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.178
Instability index50.01
Isoelectric point9.02
Molecular weight175492.75
Publications
PubMed=28196534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11628
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     312.21|      95|     309|    1072|    1180|       1
---------------------------------------------------------------------------
 1072- 1180 (149.34/130.28)	RYADMVtYRYYLAQQEFidKHPeecleiirdaVPMVNTRP.PGIAWVSNQTDLITCAMNLLQTLLTQKPERMVQCCMQKFI..GQDLASTALLQKALDALLGFGSQdPQAMP
 1395- 1492 (162.87/106.48)	RLPDRV.IRLYPSANYF..PHP..........VQSENYRPcPGILLQTHALDVAAALIDTFPDEARQQCARFLREKCPPFLqfQNDSRFLYLLGPMLDTSSSNPPQ.PASLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.57|      33|      34|      81|     114|       2
---------------------------------------------------------------------------
   81-  114 (55.32/30.94)	PLGSCPAEGSPAPGSGGEARSTPGTASSKpNPLS
  119-  150 (47.00/21.33)	PVWSFQALVSETSGA.TETKEDDATSQGK.NPAS
  153-  181 (39.25/16.34)	PLPLVPWKYTPQESSGSNSAGPADIAPTK.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     339.35|     120|     315|     190|     393|       4
---------------------------------------------------------------------------
  247-  374 (193.34/192.96)	YAQLKhRSGLQMLSSVFAaalekrQSHNTVTAPSSFKPPPRVTlTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLD...QCLGKGIPVPRAIWLARCVGA...NEIRAFKR...KGTSGALAL.GLETKWVRD
  735-  809 (67.28/ 9.15)	...............................................................QRLPKIFGAQISDAMLTDlslPSLTWAVKSEIGLWIRRGVSEhrrDPIRKYAHipmLADSGVSALtPVEFYNIRD
  867-  929 (78.72/17.37)	YARLK.RLGAPSLDLIFS......LIELGLRMPSEFNTVALLR.QDLSRIESKSALAAPSPLSDHIPMGFG...................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.25|      34|     144|     552|     588|       5
---------------------------------------------------------------------------
  552-  588 (49.60/49.96)	RLPqQYIIHLFDSIRSAHDISATS.STCLGAVedKASL
  699-  733 (52.65/39.30)	RLP.EYVRNLRNTLLSRTGMPASQeESVIAAV..KASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.27|      18|    1303|      23|      41|       6
---------------------------------------------------------------------------
   23-   41 (29.49/25.90)	SGRVDASQTlGQPDSQLEK
 1329- 1346 (32.78/23.32)	SGAVDASQT.AQVRSNFER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11628 with Med12 domain of Kingdom Fungi
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