<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11624

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFSLPLRPLTEKRDRPDTLPIEIAQINARWGSFRDVNEETLRAKIEEDKIRDPWSDEDEGDKPTEDVDTTERREQLYKRRAEILQFAMQAHMEALFALDFVSLLLSKHTPRQAETSMSTFLKQVAPLGSLNSEIVNPPPKSEATVQDVKTVSRGWRLQNFNAAANKLLNSATRLETEVASETKYWDEVLAIKEKGWKVCRLPRERQALGVQYGFLEATPIFRDRGLAALRRGDNGTLRLDKGLAPQTTRTVRVRVKHRGRLTGCSKLPELPGTVSVERTILQARDTVYEEELFHELMREARIMGSQGVTTRQNLVRVPISEEQEVLLDLVDADDAPANDGEMESTEHSVLADAVSHSIRILLAYAHRQNLRRRTLPPPALSNKRRHTPEYQLLRPVMAYLQHSAHVRWLESFLNDIYRVLRAAGFQCDFHAVPFSSVSLPRMHPAVPKVEGLVQQFLMPFESTFSGHLVTPESSFKVKIRTNPAAPPFGTQYDISVDLPHHPDVQPPSRVGLQSDAAAAITHVFKLDIISAIAVHGSKSAQDSTRKEGEKELLTWEAAYPHHGELLALSTTGRSKKLKVTLSQQELTIETYSMRGIDGHGQSAGTKSPSHMQTWRCDQMGSQPSLMEFVAQVSREQS
Length640
PositionHead
OrganismAspergillus carbonarius (strain ITEM 5010)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.501
Instability index49.99
Isoelectric point6.90
Molecular weight72082.90
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11624
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.99|      17|      58|     439|     455|       1
---------------------------------------------------------------------------
  439-  455 (32.61/15.89)	SVSLP.RMHPAV..PKVEGL
  477-  492 (18.16/ 6.16)	SFKVKiRTNPAA..PPF.G.
  498-  515 (26.22/11.59)	SVDLP.H.HPDVqpPSRVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.81|      55|      63|     165|     220|       3
---------------------------------------------------------------------------
  165-  220 (88.61/60.50)	AAANKLLNSATRLETEVASETKYWDEVlAIKEKGWKV.C.RLPRERQALGVQYGFLEA
  230-  286 (83.20/52.41)	AALRRGDNGTLRLDKGLAPQTTRTVRV.RVKHRGRLTgCsKLPELPGTVSVERTILQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.27|      44|     272|      30|      75|       4
---------------------------------------------------------------------------
   30-   75 (74.54/51.09)	NAR.WGSFRDVNEETL.RAKI.EEDKIRDPWSDEDegDKPTED..VDTTER
  302-  350 (57.73/33.31)	EARiMGSQGVTTRQNLvRVPIsEEQEVLLDLVDAD..DAPANDgeMESTEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11624 with Med17 domain of Kingdom Fungi
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