<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11589

Description "Mediator complex, subunit Med12"
SequenceMQRYHPANCTSAVNNSAIGGASARDTSRADSSTLPPNFSLNSRRQSQLAPYKLKCDKESLNSRLGPPDFHPQSQNCPEETLTRENVQQGYKETIDGLEDSKEISLTQIQAFTKPVVLKCRDAIRKCLRAINESRAQKRKAGQVYGIPLSGSLLSKPGVFPEQRPCNEDFRKKWIEGLSQQHKRLRSLADQVPHGYRKRTLIEVLIRNNVPLLRATWFIKVTYLNQVRPGSAISSGAPDKTQLSRTELWTKDVIDYLQYLLDEFSSRNNSHSTQHGRDRLPQMLYTGSLQHRNDSALTIIDGEEPSLHFKWWYVVRLLQWHHAEGLVLPSLIIDWVLSQLQEKELLEILQLLLPIIYGVLETIILCQTYVRNLVGIAIRFIREPSPGGSDLVDNSRRAYTISALVEMLRYLIQAVPDTFVALDCFPLPACVVSHALNDGGFLSKLSDDAGKTKNTLADAYVLKGRGFDSQYQSLSFDHVVSTIQKRADYLAKGASAEYPSQSVAKAVQTLDKALLQGDLVEAYKLIFEDLCDGVVGEGWVSEVSPCLRSSLKWVRTVNLSFICSVFFLCEWATCDFRDFRTAPPRDVKFTGRKDISQIYLAIQLLKLKMRELQNPQHKNGRASKSTAKYSSQQNNYSRRTLLGNQYEAKSNARGMDGRSSNSSDLFDSPGPLHDIIVCWIDQHEGHKGEGGKRLQLFVLELIRSGIFYPLAYVRQLLVSGIIDTNGPVGDLDRRKRHHRILKQLPGQFMRDALEEARIAEASELLEAVNVYSNERRLVLKGLLFDQCNNANYANVSSKKQKYHATSAKDAASQASGDQWKIGHSSKIFRRDVDLEELKASISVLLQFPSSSSTSADSGVDESQGSAKRSVGSIGNKMDSFEGTPGCEDCKRVKRQKLSEEKSSSLQVPSPIPSDDEDTWWVRKGPKNLESFKADPPLKSTKQVSRGRQKTVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTDPETLKPVDGIRTTPSGDIVSIGKGLKQLRFVEKRTVTVWLISVVRQLVEEYEKSVAKVGQYGRPFVAADEKSPLRWKLGEDELSTILYLMDVSCDSALAVKFLLWLLPKVISNPSPTIHGGRNIIMVPRNVENHACEVGEAYLLSSLRRYENILIAADLIPEALSATMHRAAAVLATNGRITGSGALVFARYLLKRYGNITSVIEWEKNFKPTCDKRLLSELESGRTVDGEFGFPLGVPAGIDDPDDYYRQKIASGRVSRVGLNMRDMVQRHIDDVLHYFLGKERKVFAGNAPKGLAVEKGDDGYQVAQQIIVGLLECLRQTGGAAQEGDPGLLSSAISAIVSNVGPAIAQIPDFTVGGNYSNYQQPMNSLNIAKRILRIHIICLSLLKEALGERQSRAFEVALGTEASSALAVAFAPAKSSRGQFQLPPDGPDSNANIPGDNMSSAKVTHGRTTKMAAAVSSLFIGAVIHGVISLERMVSVLRLKEGLDVVQFVRNTKTSSNGNARSAGAFKDNLVEVNVHWFRLFVGNCRTVCDGLVLELLGEQSVVALSRMQRLLPIDLVFPPAYAIFAFVIWKPFILNSNIATREDIHQLYLSLTMAIGDAIKHMPFRDACMRDSRTFYDIVAADTTDTEFAALLEMNGLDMHLKSMAFVPLRARLFLNAIIDCEMPYSASQQDDGTRVSGHSESKALRESEPKLSDKLVRALDTLQPAKFHWQWVELRLLLNEQALIDKMETHDMPLVDAIRSSSPSSERASPSENEKFLIEIILTRLLVRPDAASLFSEGRQKKYEVTSLEEGEVIEEGMESKRNVKGSSKIDLGSSISRLHVTEKAFVELVLPCIDQSSDDSRNTFASDLIKQFNTIEQQMSSVTRGVSKQTGTASSGIEGSVSKGNNRKGIRGGSPGMSRRTAVPAESAPPSPAALRASMSLRLQIIVRLLPIICADGEQSARNMRHMLASVILRLLGSRVVHEDVDLSLNLLNSKRDMEMMSSVASSEMSGDSLFDRLLLVLHGLLSSCQPNWLRSKTATKATSEFAKNSSGFDREAVESLQNELESMQLPEMIRWRIQAAMPILFPSFRNLISCHPPSVPIGALSSLQPSIFVPGSYLGTLSAPQRQGPSTRTSNNTQGKSKSMPVVQEYVMEIDPWTLLEDGAGSGPSTSSTAVIGSSDHANLRASSWLKGAVRVRRTDLTYIGAVDDDS
Length2189
PositionKinase
OrganismCorchorus olitorius
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Grewioideae> Apeibeae> Corchorus.
Aromaticity0.07
Grand average of hydropathy-0.282
Instability index50.13
Isoelectric point8.76
Molecular weight242161.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11589
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     254.56|      75|     245|     736|     857|       1
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  776-  857 (110.49/16.84)	LVLKGLLfDQCNnanyANVSSKKQKYHATSakDAASQASG.DQWKIGH...SSKIFRRDVDLEEL.....KASISVLLQFP...SSSSTSADSG
 1055- 1109 (58.78/78.62)	.................................AADEKSP.LRWKLGEdelSTILYLMDVSCDSA.....LAVKFLLWLLPkviSNPSPTIHGG
 1997- 2065 (85.30/17.50)	LVLHGLL.SSCQ....PNWLRSKTATKATS..EFAKNSSGfDREAV.E...SLQNELESMQLPEMirwriQAAMPIL..FP...S.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     280.16|      91|     364|     262|     361|       2
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  262-  361 (135.19/96.27)	EFSSRNNSHS..TQHGRDRLPQMLYTGsLQHRNDSALTIIDGEEPsLH...FKWwyvVRLLQWHHAE.GLVLPSLIIDWVLSQLqEKELLEILQLLlpiIYGVLET
  627-  723 (144.98/77.31)	KYSSQQNNYSrrTLLGNQYEAKSNARG.MDGRSSNSSDLFDSPGP.LHdiiVCW...IDQHEGHKGEgGKRLQLFVLELIRSGI.FYPLAYVRQLL...VSGIIDT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.43|      28|     247|    1708|    1742|       3
---------------------------------------------------------------------------
 1708- 1742 (36.56/44.48)	VELRLLLneqaLIDKmetHDMPLVDAIRSSSPSSE
 1962- 1989 (47.87/33.88)	VDLSLNL....LNSK...RDMEMMSSVASSEMSGD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.41|      33|     247|    1893|    1925|       4
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 1893- 1925 (56.05/35.26)	GMSRRTAVPAESAPPSPAALRASMSLRLQIIVR
 2143- 2175 (56.36/35.50)	GSGPSTSSTAVIGSSDHANLRASSWLKGAVRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.08|      45|    1216|     373|     449|       5
---------------------------------------------------------------------------
  373-  419 (67.30/101.07)	VGIaIRFIREpSPGGSDLVDNSRRAYTISALVEMLRYLIQAVPDTFV
 1301- 1345 (75.78/38.28)	VGL.LECLRQ.TGGAAQEGDPGLLSSAISAIVSNVGPAIAQIPDFTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.28|      73|     926|     858|     944|       6
---------------------------------------------------------------------------
  858-  944 (101.38/97.30)	VDESQGSaKRSV.GSigNKMDsfEGTpgcedckRVKRQKLSEEKSSSLQVPS.PIPSDDEDTWWVRKGPKNLESFkaDPPLKS.TKQVSR
 1790- 1865 (108.90/65.50)	IEEGMES.KRNVkGS..SKID..LGS.......SISRLHVTEKAFVELVLPCiDQSSDDSRNTFASDLIKQFNTI..EQQMSSvTRGVSK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.99|      63|     192|    1218|    1286|       8
---------------------------------------------------------------------------
 1218- 1286 (104.00/78.97)	GEFGFPlgvPAGIDD....P.DDYYRQKIASGRVSRVGLNMRDMvqrHIDDVLHYFLGKERKVFAGNAPKGLAV
 1412- 1479 (98.99/60.96)	GQFQLP...PDGPDSnaniPgDNMSSAKVTHGRTTKMAAAVSSL...FIGAVIHGVISLERMVSVLRLKEGLDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.37|      13|     987|     591|     603|       9
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  591-  603 (22.46/14.71)	RKDISQIYLAIQL
 1576- 1588 (23.90/16.16)	REDIHQLYLSLTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.84|      39|     633|     726|     764|      10
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  726-  764 (68.26/53.47)	PVGDLDRRKRHHRI.......LKQLPGQFMRDALEEARIAEASELL
 1355- 1400 (57.58/43.69)	PMNSLNIAKRILRIhiiclslLKEALGERQSRAFEVALGTEASSAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11589 with Med12 domain of Kingdom Viridiplantae
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