<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11584

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVSRTAEESFLSLKELVEKSKSSDQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLTSTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKCIEDVGMQSSLNEDQQKPALRKLDTLVRSKLLEVSMPKEITEVKVSNGTALLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLVKLEEMRRHVLGDDLERRMSAAENPFNILYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGGSGSSTQVNQDNESDSAGLRTPGLKLVYWLDFDKNSGPSDSGSCPYIKIEPGPDLQIKCHHSTFLIDPLTGKEARFSLDQSCIDVEKLLLRAISCHKYTRLLEIQKELVKNVQICRAASDVVLHSPADDSDSENKKKDAKLDNKEHEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSQNILAPSALLECEEALNQETMNAVEVFTSLRNKSVLHLFAAIGRFLGLEVYEHGFAAMKVPKNIVSGSAVLVLGFPDCESSYFLLMELDKDFKPLFKLLETEPDPSGKGQSFYDLNNVLRIKKIDINQMQMLEDETNLSIVDWGKLLTFLPNIVGPNQTSEHGLLSEFNLDGSMQIAGGPSSSFSSIVDEVFEIEKGTSATTFPSQNFSSFSSSPASHMGSVPMNLHTVKAGTASPKWEVGLQASQLNNVAKVSSPASHYGGSLYPSSGLKGSHHSSSFGSLSSATGRSTAAKKLSASKSDQDLASLRSPHSVEIGALDEDQLRLLNDASKDALSASRSSRLLSPPRPNVPRVSAQGAKPNGPRSSSSARFAGSSPLSSPPISQAAETTFSHGTSHDATKHDKNPRKRTVSDMLSLIPSLQGIEAVAGFGKRRKTSDVAYTQQPSSQVLMSSEMISKSETYSYGNLIAEANKGNAPSSIYVSALLHVVRHSSLCIKHARLTSQMEELDIPYVEEVGLRNASSNIWFRLPSARGDSWRHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNSTPWGTGVRIANTSDVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARMFSLGMRKLLGVRADEKPEDGGANPDVKTAVGVKSAVEAADKLSEQMRRSFKIEAVGLLSLWFCFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVPGVSAPISSMSKQSGYIPSQGLLPSSSTSNVNQAASAPAGNTAASAASSLGNHGLHGAGMLVNPGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPATPPRGGSSVGGSLPCPQFRPFIMEHVAQELNGLDSGFTGGQQAVGLANSNNPNSNSGPQLSANGNRVNLPTSAAMSRAANQVAGLNRVGNALPGSPNLAVVSSGLPIRRSPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNNANAQEELSQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGDIAPAQKPRIELCLENHSGVNADDSSESPSTTKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGEDPNVSFLGMEGSHGGRACWLRLDDWEKCKQRVARTVEVSGRSPADASQGRLRAVADNVQRALICAFKD
Length1805
PositionTail
OrganismCorchorus olitorius
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Grewioideae> Apeibeae> Corchorus.
Aromaticity0.06
Grand average of hydropathy-0.236
Instability index49.22
Isoelectric point7.59
Molecular weight196274.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11584
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.80|      38|      38|     740|     777|       1
---------------------------------------------------------------------------
  648-  681 (41.47/20.28)	...SSSFSSIVDEV..FEIEKGTSATTfPSQ..NFSSFSSS
  684-  723 (56.34/30.23)	SHMGSVPMNLHTVKAGTASPKWEVGLQ.ASQlnNVAKVSSP
  740-  777 (58.99/32.00)	SHHSSSFGSLSSATGRSTAAKKLSASK.SDQ..DLASLRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.79|      24|      34|     802|     831|       2
---------------------------------------------------------------------------
  803-  827 (42.20/24.28)	ASRSSRlLSPPRPNVPRVSAQGAKP
 1220- 1238 (34.77/12.48)	ATRPAR..ASPAPGVPGVSA....P
 1240- 1256 (24.81/ 8.05)	...SS..MSKQSGYIP...SQGLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.66|      44|     762|     961|    1012|       3
---------------------------------------------------------------------------
  961- 1012 (62.78/54.65)	CIKhARLTSQMEElDiPYVEEVGLRNA..SSNIWFRLpsargDSWRHICLRLGR
 1726- 1771 (78.87/42.85)	CVS.VRLRYSFGE.D.PNVSFLGMEGShgGRACWLRL.....DDWEKCKQRVAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.59|      15|      34|     346|     362|       4
---------------------------------------------------------------------------
  346-  362 (23.91/23.36)	IKCHHSTFLIDplTGKE
  382-  396 (27.68/18.41)	ISCHKYTRLLE..IQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.51|      29|     447|     832|     865|       5
---------------------------------------------------------------------------
  832-  860 (49.15/32.05)	SSSSAR.FAGSSPLSSPPISQAAETTFSHG
  868-  897 (45.36/19.15)	HDKNPRkRTVSDMLSLIPSLQGIEAVAGFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.44|      34|     946|     200|     235|       6
---------------------------------------------------------------------------
  200-  235 (55.62/43.25)	GHLSLWRIL...HLELLVGERSGlvKLEEMRRHVLGDDL
 1148- 1184 (59.82/40.32)	GLLSLWFCFgsgVLARFVVEWES..GKEGCTMHVSPDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.76|      19|     454|     556|     576|       7
---------------------------------------------------------------------------
  556-  575 (30.08/25.99)	DK.DFKPLfKLLETEPDPS....GK
  589-  612 (23.68/ 8.87)	KKiDINQM.QMLEDETNLSivdwGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.67|      26|      38|     277|     304|       8
---------------------------------------------------------------------------
  277-  304 (40.63/25.76)	WKDAIRFELISDggSGSSTQVNQDNESD
  318-  343 (51.04/26.54)	WLDFDKNSGPSD..SGSCPYIKIEPGPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      12|     759|     727|     738|       9
---------------------------------------------------------------------------
  727-  738 (23.55/13.35)	YGGSLYPSSGLK
 1488- 1499 (24.41/14.15)	YGGGWVPVVALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.13|      22|      56|    1287|    1310|      19
---------------------------------------------------------------------------
 1287- 1310 (38.31/21.92)	LHGAGMLVNPGRGGPGIVPSslLP
 1345- 1366 (42.82/19.74)	LQPATPPATPPRGGSSVGGS..LP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11584 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HSSSFGSLSSATGRSTAAKKLSASKSDQDLASLRSPHSVEIGALDEDQ
2) LSASRSSRLLSPPRPNVPRVSAQGAKPNGPRSSSSARFAGSSPLSSPPISQAAETTFSHGTSHDATKHDKNPRKRTVSDML
742
801
789
881










Molecular Recognition Features






MoRF SequenceStartStop




NANANA