<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11486

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVSRTAEESFLSLKELVEKSKSSDQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLTSTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKCIEDVGMQSSLNEDQQKPALRKLDTLVRSKLLEVSMPKEITEVKVSNGTALLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLVKLEEMRRHVLGDDLERRMSTAENPFNILYSVLHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGGSGSSTQVNQDNESDSAGLRTPGLKLVYWLDFDKNSGPSDSGSCPYIKIEPGPDLQIKCHHSTFVIDPLTGKEARFSLDQSCIDVEKLLLRAISCHKYTRLLEIQKELVKNVQICRAASDVVLHSPADESDSENKKKDAKLENKEHEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSQNILAPSALLECEEALNQGTMNAVEVFTSLRNKSVLHLFAAIGRFLGLEVYEHGFAAMKVPKNLVSGSAVLVLGFPDCESSYFLLMELDKDFKPLFKLLETQPDPSGKGQSFYDLNNVLRIKKIDINQMQMLEDETNLSIVDWGKLLTFLPNIVGPNQTSEHGLLSEFNLDGSMQIAGGPSSSFSSIVDEVFEIEKGTSATTFPSQNFSSFSSSPASHMGSVPMNLHSVKAGTASPNPASHYGGSLYPSSGLKGSHHSSSFGSLSSATGRSTAAKKLSASKSDQDLASLRSPHSVEIGALDEDQLRMLNDASKDALSATQAAETTISHGTSHDAAKHDKNPRKRTVSDMLSLIPSLQGIEAVAGFGKRRKTSDVPYTQQPSSQVLMSSEMISKSETYSYGNLIAEANKGNAPSSIYVSALLHVVRHSSLCIKHARLTSQMEELDIPYVEEVGLRNASSNIWFRLPSARGDSWRHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNITSWGSGVRIANTSDVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARMFSLGMRKLLGVRADEKPEDGSANPDVKTAVGVKSAVEAADKLSEQMRRSFKIEAVGLLSLWFCFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVPGVSAPISSMSKQSGYIPSQGLLPSSSTSNVNQAASAPAGNTAASASASSLGNHGLHGAGMLVNPGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPATPPRGGSSVGGSLPCPQFRPFIMEHVAQELNGLDSGFTGGQQAVGLANSNNPNSNSGPQLSANGNRVNLPTSAAMSRAANQVAGLNRVGNALPGSPNLAVVSSGLPIRRSPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNNANAQEELSQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGDIAPAQKPRIELCLENHSGVNADDTSESPSTTKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGEDPNVSFLGMEGSHGGRACWLRLDDWEKCKQRVARTVEVSGRSPADASQGRLRAVADNVQRALICAFKD
Length1742
PositionTail
OrganismCorchorus capsularis (Jute)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Grewioideae> Apeibeae> Corchorus.
Aromaticity0.06
Grand average of hydropathy-0.223
Instability index47.23
Isoelectric point6.86
Molecular weight189751.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP11486
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.19|      37|      53|    1155|    1192|       1
---------------------------------------------------------------------------
 1155- 1192 (61.52/32.16)	AATRPARASPAPGVPGVSAPISSMSKQSGYIPSqGLLP
 1211- 1247 (65.68/30.98)	AASASASSLGNHGLHGAGMLVNPGRGGPGIVPS.SLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.87|      42|     293|     313|     356|       2
---------------------------------------------------------------------------
  313-  356 (71.86/49.18)	LKLVYW...LDFDKN.SGP...SDSGSCPYIKIEpGpDLQIK.CHHSTF..VID
  605-  656 (53.01/27.49)	LSIVDWgklLTFLPNiVGPnqtSEHGLLSEFNLD.G.SMQIAgGPSSSFssIVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.55|      51|      70|     792|     843|       3
---------------------------------------------------------------------------
  792-  843 (83.52/68.58)	TISHGTSHDAAKHDKNPRKRTVSDMLSLI.PSLQGIEAvAGFGKRRKTSDVPY
  863-  914 (83.03/63.02)	TYSYGNLIAEANKGNAPSSIYVSALLHVVrHSSLCIKH.ARLTSQMEELDIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.57|      28|      49|    1010|    1037|       6
---------------------------------------------------------------------------
 1010- 1037 (45.23/33.35)	ADSIKKLVADIRRLSNA..RMFSLGMRKLL
 1057- 1086 (38.34/27.00)	AVGVKSAVEAADKLSEQmrRSFKIEAVGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.86|       9|     943|     688|     783|       8
---------------------------------------------------------------------------
  679-  687 (18.74/19.56)	SSSPASHMG
  702-  710 (20.12/80.05)	SPNPASHYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.13|      15|      17|     737|     751|      10
---------------------------------------------------------------------------
  737-  751 (23.21/14.70)	RSTAAKKLSASKSDQ
  757-  771 (25.92/17.38)	RSPHSVEIGALDEDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.43|      70|     260|    1289|    1429|      14
---------------------------------------------------------------------------
  918-  995 (118.41/50.44)	VGLRNA...SSNIWFRLpSARGDswrhiclRLGRPGSMYWDVKIND.QHFRDLWELQKGS.NITSWGSG..VRIANTSDVDSHIR
 1333- 1409 (102.02/144.73)	VGLANSnnpNSNSGPQL.SANGN.......RVNLPTSAAMSRAANQvAGLNRVGNALPGSpNLAVVSSGlpIRRSPGSGVPAHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.63|      19|     260|    1410|    1429|      15
---------------------------------------------------------------------------
 1410- 1429 (33.94/25.36)	GElNTAIIGLGDDGGYGG..GW
 1673- 1693 (35.69/21.80)	GE.DPNVSFLGMEGSHGGraCW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11486 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TAAKKLSASKSDQDLASLRSPHSVEIGALDEDQLRMLNDASKDALSATQAAETTISHGTSHDAAKHDKNPRKRTVSDM
739
816










Molecular Recognition Features






MoRF SequenceStartStop




NANANA