<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11469
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPEKAGQDKDNPNNNTKADKNKSGIQSINGDSIHTLNNEALQSSSDIDMGDSVLLESQSSSSINNNSSIIKPLPSSNDDDFTNNVDFIEQIPNSLAGNIPLSHIIERVNTHAYTELLNLVETMPSKINEDKKKLALEYTFQMRQAFVKLIAVTRWAKDSEEINKAQKIVALLQSQNEFFNKSVDGVFGSGVLLSQSRVKNYDVLGAIDIFKTGSYNFLPEEYLKRFITTPPLTLVEKKVAISNIQDEIRYRLATGEPIPSNMMLYTVDNGCVTFTVKNEYKISLTMLQFSRRVPWHVVSLEILAGSNTDLSNDLKFELTERQKQKLSSLCQNILVDAELEYSESLPNNNDLAHSSTDNLINSPTSDSSPGQTFDTHPFKDTFSKIPPLVQLNDFLRKHILL |
Length | 401 |
Position | Tail |
Organism | Smittium culicis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Kickxellomycotina>
Harpellomycetes> Harpellales> Legeriomycetaceae> Smittium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.426 |
Instability index | 50.53 |
Isoelectric point | 5.16 |
Molecular weight | 44925.02 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11469
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 55.25| 14| 15| 42| 55| 1
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36- 54 (19.83/ 8.99) LnnealQSSSDIDMGDSVL
55- 70 (18.44/ 7.88) L...esQSSSSINNNSSII
73- 85 (16.98/ 6.70) L.....PSSNDDDFTNNV.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.05| 21| 332| 12| 32| 2
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12- 32 (37.83/21.26) PNNNTKADKNKSG.IQSINGDS
346- 367 (34.22/18.60) PNNNDLAHSSTDNlINSPTSDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.65| 16| 17| 169| 185| 3
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170- 185 (26.86/18.14) ALLQSQNEFFNKSVDG
190- 205 (24.80/11.06) GVLLSQSRVKNYDVLG
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