<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11459

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILENGMNSSMQVDQLDVDDLFGDGVGLSLPTARPITKPLRQRIDELRTRGCCQGVAWSRSGAIASISPDGRSLEARFLRSHPDDGEWGLSEPAKVDLISINATSPIVHLAWASTASPELAVIDATGRVAILTYSITLNRPFATRKWDNDPSDDLHAIVGSYWLPLAPQSKQYYVSHGPAVKDGNSYRYESSFIHAYGPWHPNPSKSALMCVTTNGILKMFWAQNNNKIEESTLELESVNSSDDLITHAALHSDKSNLWVAMATTSKQLRVVRVGIHWGLPQSQSDNKPPPGSQALNPTMQEKHVAISSWLPNGQSTTPVDSATNQLTHLEILPSTMDLTGQGWAPLIVLAVRVYLPNPNTPYQETQSIIDKWEVLNDQTQGLHPAFEQLGSRRNSTGSVPAPTSRLKRYEPVIINKAVVGVSTLQYGRVVCLAFADGSVEYRDRFTMGEIYSEINLDRVMNLHQVGFTFQDDAPCVQLAFSPTHCSLVKIQDDGKVKWSKLHHPLGDIGNTNRDAQYAATLAALTVAASTATFNNINYDDILAVARPYADKKRFTFDWINEIVRMLKIPVDYSEDTHHDSLVRNSSLQMCLSILNHLGYKGMFQPRSFGGKFAMLALNARNVVILITIASNTPVNIREKLSPLDEHEVVDALCGCAKWSLDLLSWLTDSLFSLLDDSQFQALLTPQRFSEMSTYLQSRADVSLHLLLCSSTRGFLSAVCRRILHLEILSNRAIEFYERRAAMHNATDPSSSQHKGLHVVLYKAYQKMQRITSSSLIKVQEFDRLLTVLNNDIRTAYQTSLASLASKNPAAAAAGSKAVDAQIKNAQIHCELNMLLASSPPPAFLGVLLKFFNNDLRTYRAQTDPSRLFFADFDLLEIEDDRRALAARKASGRYIDVFKRVELLAQPAKGATTDEETKTGDEVKTPQWRRCVRCSAVMEDVFGSRPGFTFVLAQQRKCSCGGHWGLLPRGQLIS
Length976
PositionTail
OrganismColletotrichum chlorophyti
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index43.07
Isoelectric point6.97
Molecular weight108308.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11459
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.54|      96|     158|     422|     524|       1
---------------------------------------------------------------------------
  422-  524 (151.29/137.47)	VGVSTLQygrvVCLAFADgSVEYRDRF...TMGEIYSEINLDRvMNLhQVGFTFQDDAPC.VQLAFSPTHCSLVKIQDDGKVKWS.KLHHPLGD.IGNTNRDAQYAATL
  585-  686 (147.25/107.98)	VRNSSLQ....MCLSILN.HLGYKGMFqprSFGGKFAMLALNA.RNV.VILITIASNTPVnIREKLSPLDEHEVVDALCGCAKWSlDLLSWLTDsLFSLLDDSQFQALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     275.28|      69|     146|      99|     167|       2
---------------------------------------------------------------------------
   99-  163 (104.41/66.14)	..............................................DLISINATSPIVHL.AWA..ST......ASPELAVIDATGRVAI...LTYSITLNRPF.ATR....KWD..NDPSDDL..HAIVGS
  164-  255 (40.84/21.10)	YWLPlapqskqyyvshgpavkdgnsyryessfihaygpwhpnpsksALMCV.TTNGILKM.FWA..QNnnkieeSTLELESVNS....................................SDDLitHAALHS
  260-  311 (64.98/38.20)	LWV.............................................................amAT......TSKQLRVV....RVGIhwgLPQSQSDNKPP.PGS....QAL..NPTMQEK..HVAISS
  312-  386 (65.05/38.25)	.WLP..................................ngqsttpvD....SATNQLTHLeILP..ST......MDLTGQGWAPLIVLAV...RVYLPNPNTPYqETQsiidKWEvlNDQTQGL..H.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.41|      65|     874|      22|      92|       3
---------------------------------------------------------------------------
   22-   92 (108.29/80.52)	DLFGDGVGLSLPTARPITKPLRQRIDELRTRgccqgvAWSRSGAIASISPD..GRSLEARFL....RSHPDDGEWGL
  898-  968 (109.12/67.06)	DVFKRVELLAQPAKGATTDEETKTGDEVKTP......QWRRCVRCSAVMEDvfGSRPGFTFVlaqqRKCSCGGHWGL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11459 with Med16 domain of Kingdom Fungi
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