<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11457

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRIVRGVQHAALEQWSQFIAKSLAHRIDPDKFESYVPFLQAKHPLPPVAVADLFLRPQPHNRASLDPRVPRYLQVLSDLNYIDTPSILKALYKYSTSRAHSRDAAQPTDQEAAEAQKPNTLRWGSSYAAEEVMFYRLTKSVAQGTAIRNMETGLEIANIMAKWIALFTDAATAFTVDVMGQLHTSQVREEMESARAAFVALLLGVCENAVVLKAFGRPEAQNTRKGLSESLANFVPTIMQSAGPIATRLDMFRTSTLASFEPVDEQKNKSNAEIDDLFDSTVALENFVISELPIVNSRAGLYIYLNAVLVGRPLIDDVAIFNYLNNRYQGDVQSTTIDLILASFDVLANSVSRNEGNPTAHLLRSFLMNKLPLLIENLSKHMYPPLTAEYCITEALRRVDTNTFPTLSSMFDDTRSNNPFMESVREEFCWACCLHGLVRESSIETLLGETPYQSLPTAGRYVKENLVAECLADPERMQALIAELDGKDGNAGAVCQALTEVLVQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPVAILHPLCDLLDGWKYDEDQGEYQPVYEEFGSVLLLVMAFAYRYGLSALDMGVSAPDSFVARLLGQGHQSRPLDELSEQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLVVSTLFQNIVLAFSTGHLSEESLKGGIEYLVDTFLLPSLVVAITYLANSLWVERSECQKAIVRVLNFVLTPAAISNEASAMLSSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDSWSLVGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVALKILGAKRLLQLLYEDIRQQTETGSGSIIYDVATAMVCAPDVFNSPPASALNFLDNPGNVPSPVQRKLALRDVLKSDAEDCMRLKKTDMNLAEIVVRLYRKVEAQMAVSQAQVIQAESMLQNDLGLDLGNGAGSLDDAMAAAAANVTQGDGMSVDNVSLDLGLGGVGGDMGLGSSSNNAGGSLDLGADDLFSGLGAGDDFQWDNMDLS
Length1039
PositionTail
OrganismColletotrichum chlorophyti
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.07
Grand average of hydropathy-0.067
Instability index41.61
Isoelectric point4.86
Molecular weight114091.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11457
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.77|      25|      26|     976|    1000|       1
---------------------------------------------------------------------------
  943-  960 (20.61/ 8.09)	...............QVIQ.AESMLQNDL..GLDLG
  961-  993 (37.07/20.51)	NGAGSLDdamaaaaaNVTQ.GDGMSVDNV..SLDLG
  994- 1017 (27.09/12.98)	LGGVGGD............mGLGSSSNNAggSLDLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.60|      25|      25|     338|     362|       2
---------------------------------------------------------------------------
  323-  336 (16.42/ 6.85)	.........FNYLNN...RYQGDV.QS
  338-  362 (39.24/27.84)	TI.DLILASFDVLANSVSRNEGNP.TA
  364-  390 (30.94/20.21)	LLrSFLMNKLPLLIENLSKHMYPPlTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.72|      22|      25|     233|     256|       3
---------------------------------------------------------------------------
  233-  254 (39.25/30.39)	LANFVPTIMQSAGPIATRLDMF
  259-  280 (37.48/21.42)	LASFEPVDEQKNKSNAEIDDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.76|      19|      36|     448|     482|       4
---------------------------------------------------------------------------
  426-  445 (30.60/33.40)	VREEFCwACCLHGLVRESSI
  464-  482 (32.16/ 8.60)	VKENLV.AECLADPERMQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.31|      20|      37|     773|     807|       5
---------------------------------------------------------------------------
  773-  796 (29.51/36.02)	SI.P.LSRRTGAADHTELdswsLVGF
  811-  832 (29.79/ 8.01)	SIhPtMDRMPPAYTHRQM....LVAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.96|      14|      29|     652|     665|       6
---------------------------------------------------------------------------
  652-  665 (23.28/16.93)	YLVVSTLFQNIVLA
  682-  695 (23.68/17.36)	YLVDTFLLPSLVVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.54|      19|      29|     505|     523|       7
---------------------------------------------------------------------------
  505-  523 (33.20/23.27)	VQLCRNKETMSLKLLCSQL
  532-  550 (34.33/24.32)	VMLMFEKPVAILHPLCDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.95|      30|     384|     192|     228|       8
---------------------------------------------------------------------------
  192-  228 (46.67/40.89)	EME.SARAAFVALLLGVCENAvvlkafgRP..EAQNTRKG
  589-  621 (46.27/26.74)	DMGvSAPDSFVARLLGQGHQS.......RPldELSEQEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.86|      14|      15|     871|     884|       9
---------------------------------------------------------------------------
  871-  884 (25.98/17.54)	PDVFNSPPASALNF
  888-  901 (23.88/15.44)	PGNVPSPVQRKLAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11457 with Med5 domain of Kingdom Fungi
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