<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11455

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVNMENGGLNGTHPNHDRNMKVNGVNAGGKMEGQPSPNKGKAPADNPSAANGVASDSNGKQQSQMSTGLTLQQRSRMNDLPDEIVHITQGYIPLSTIVSRLAQRTHEDLQKTIMEMAAVKWQPPAVNGTTPNGNDAPDDMSEGNKRKKMLMLKFAQDAHSKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLYDYTQGLLIDLKRSLITARLPNPDLKTALQVLTTGEASWVPEPGYIPPSPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPYQFRNYTIQSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFAFSPSASKPSNALVSFLEGHVNEILGKDGLEGCYRFLHEFVLTHKINELKRQALELSRNTWTGMLMVEPLNRALALQYWTTRYGPNGPKSWVMVAVNSAKKTNGQVDLKQSSRLVARWYRDNKEVKDVLLPFDVDNLCAEDLLKTVVARHVEHILSSIYSKLLAYPRFAKKEASMTLRVSQTEPMESSLSMQLSSRENVTLVVEPVTGFAAITPHTKYTLNGENRLNYGGKDPAEDGVTCLENIRWGYVIEEFSRRGRSVGWRALNKSPIGNEDIKQIIRTREVFQTVFLQRQGLGQDWYVMVSLSLSGDEWWLLELDRNTPARPIKLQTRLQFNRGQPDLDDSFWSNLTLMVTSMITHATEERNLHRERINYLPKESTNLSLPPQLRIPSLFVPLSKILRRPGKSSIQNDSAGGQNQPGNQASSWAQDQVEIKFNALQHPSPVVSSQSGNGISAAEVLENAGFSFVADAIVRVRDKSKFALLKGRVDRDVFFNSKVGQFIFTVRQQVGQPMLETLTTHVKSIDRLVGFLEAMGKARGSVKCERVSLREVVFTYSDIAQPGESDSSLKPRRWRATLDLAKTDIRMSLERGNPHLRVLDLFTTLVNIRDGLKALIVYMPLLLPILRALESIESKWEVLESTDQGRVEVFPRTVDWIAIRYTLPSPTGQPRILVLDIRSRMRRGEVWWNFSRATPNGPLPLDEEFNKVLKSVWESHGDGWRGLMTGAAARPGPSTMELLTKLDDAVRTFAISGDVGETPSTAAAQTQPSQTFSANQSFGTQPTNVSQGSSRNTQGSKQTPLVLD
Length1122
PositionTail
OrganismColletotrichum chlorophyti
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index40.94
Isoelectric point9.03
Molecular weight125851.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.47|      63|     351|      48|     116|       1
---------------------------------------------------------------------------
   48-  113 (105.51/94.50)	DNPSAANGV.ASD..SNGKQQSQM.............STGLTLQQRSRMNDLPDEIVHI.............TQG.YIPL..STIVSRLaqrTHEDLQ
  129-  223 (71.96/48.16)	VNGTTPNGNdAPDdmSEGNKRKKMlmlkfaqdahskwVKALVITDWSRNAEAVSKLIDIkahidskrmlydyTQGlLIDLkrSLITARL...PNPDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.85|      35|     351|     618|     665|       2
---------------------------------------------------------------------------
  621-  655 (65.14/35.04)	VMVSLSLS.GDEWWLLELDRNTPARP....IKLQTRLQFN
 1002- 1024 (37.73/13.86)	.........GEVWW..NFSRATPNGP....LPLDE..EFN
 1026- 1060 (37.98/11.45)	VLKSVWEShGDGWRGLM..TGAAARPgpstMELLTKL...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.12|      34|     324|     582|     615|       3
---------------------------------------------------------------------------
  582-  615 (60.58/40.91)	WRA...LNKSPI..GNEDIKQIIRTREVFQTVFLQRQGL
  892-  930 (49.54/32.10)	WRAtldLAKTDIrmSLERGNPHLRVLDLFTTLVNIRDGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.61|      39|     324|     355|     408|       4
---------------------------------------------------------------------------
  355-  394 (60.79/30.50)	RFLHEFVlTHKINELKRQALELSRNTWTGM..LMVEPLNRAL
  684-  720 (51.27/20.27)	RNLHR....ERINYLPKESTNLSLPPQLRIpsLFV.PLSKIL
  745-  782 (53.55/39.79)	SWAQDQV.EIKFNALQHPSPVVSSQSGNGI..SAAEVLENA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     226.46|      76|     367|     434|     512|       5
---------------------------------------------------------------------------
  434-  512 (118.49/114.35)	LVARWYRD...NKEVKDVLlpFDVDNLCAEDLLKTVVArHVEHILSSI.YSKLLAYPRFAKKEASMTLR.....VSQ.TEPMESSLSMQ
  803-  888 (107.97/90.51)	LKGRVDRDvffNSKVGQFI..FTVRQQVGQPMLETLTT.HVKSIDRLVgFLEAMGKARGSVKCERVSLRevvftYSDiAQPGESDSSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.57|      21|     386|      17|      37|       6
---------------------------------------------------------------------------
   17-   37 (39.15/25.21)	PNHDRNMKVNGVNAGGKMEGQ
  405-  425 (38.42/24.61)	PNGPKSWVMVAVNSAKKTNGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11455 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AISGDVGETPSTAAAQTQPSQTFSANQSFGTQPTNVSQGSSRNTQGSKQTPLVLD
2) MPGVVNMENGGLNGTHPNHDRNMKVNGVNAGGKMEGQPSPNKGKAPADNPSAANGVASDSNGKQQSQMSTGLTLQQRSRMNDLPDEIV
1068
1
1122
88










Molecular Recognition Features






MoRF SequenceStartStop




NANANA