<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11451

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRTPMGVQPRPPQQRTLSSSGLSVQRPTHQRTLSAQYLPQSPVRKDNLVDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNDAMLTENPVIDSPKTLTPSRLMPKNEPSNLTDMSSPASTKGLPADVDNPPMPMPKRRPRFVVPPALKDTPTPTVAIKKDGRPKPYHIETPAAAPRYAPFGKPRTDAASKPGFGGSGGGARESNELGFADFFPWTGNHPEDQYTESIIKNGYFDKPPPSTTEASSAKAALFPALKHKSGLNLLSNIFVGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREIWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVMGGEAKWLRDWTVFVEQFVEGVSTTFGDNDWKAKVQYAYVGSSEEFGSIRLATHLYAEQLVDRDHYMDWLVSGLENSTQSKLPMWILITQIYWKDLLCLRKYGRRLVNALLGQLNAIHNDPDRDILVQLSTRLTALLTPLLSAHPDNFVSPSTWFKYRDALLASIPIDNEFAHNAFRSINTRNEHLVATASNSQPANRQILVKHLDTTFQSPCNPDLAAQCWAVSEEKSMVVRTLLEWCTSPHRPGAAKVYITASLLRAWIPAGLDVTAAILEFLSNNPPTEATSKRMFHRLVSEIVRSGDFQFQGYVFWLIARGGLRKPSDAEAEAPCATRLLVDLPLHALSSSLQATRASLLRRAAYDVNDETDDINTALKCIQHALGLPLPPGDPMLHRKPVSVGKLCRLIANSGRALQTEVGARLLQIFTHETTMPKNGPQISPAMFNFARAVLEAAADYAVLAEVVKVAVRVSSPEILASCADTVNVHLPVFAGLGLAKELFEGLMERLKIVREEQGVAARPLLASLANLATRLPGFTNTAAYLRQQLHQCDRNNPIDACSPVSDNMAAQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLESSWANSPDRQRAYSALLGRLRIFDAQHFDVRMTDWVHHVSALKARPALTDIYPLLISIGCLTLPIILTTTSVDSGRIATNPAVPSNSTTTYMQEVLHLATMPLAPKTAMTPEETCRFYIHQRVAPRQSHKDMVTLVRNALVEFSRLQGVNQHTSLPLETPAFRDNMLELLRLLVLLDPPSVVQGLGMKSPEPALNGLFAQITTKLLLPDAGEESQLTFETVLELANEFTLPFCQLKLSVGLSADTTTSPGGGEQTLSQVDMFSRAMDRAVSANNVMWTSMLPYLNEEITEHLKRQAHLRFLGLFPSQRNPSSSDPLSKDSIQLAGSLLSVVESILRGRPAPRTSQLTSGMVEKLTEVWEILAAGGDDKKELRAAILAHWLPALLRFITLHTTANEPMSAPAQSTNAMKPPANATAFEIRARILVALSGLTLELDNLPLDNAQTGRVLREQVFDLALLLVDTLPEDLRLQCVRVLLTGGTTQSPASSDARLRYLFSQMAPPTEQFVLAHRQQPTVQQTGPPRPKIPISMQGTDKFTPFMFRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1546
PositionKinase
OrganismColletotrichum chlorophyti
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.06
Grand average of hydropathy-0.224
Instability index45.01
Isoelectric point8.79
Molecular weight170432.45
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     317.67|      83|     175|     710|     793|       1
---------------------------------------------------------------------------
  710-  793 (135.34/90.64)	PLHA..LSSSL.QATR.ASLLRRAAY.....DVNDE.................TDDINTALKC..IQHALGLPLPPGDPMLHRKPVSVGKLCRLiANSGRALQTEVGARLLQ
  802-  892 (86.74/52.40)	PKNGpqISPAMfNFAR.AVLEAAADY.....AVLAEvvkvavrvsspeilascADTVNVHLP...VFAGLGLA..........KELFEGLMERL..KIVREEQGVAARPLLA
  893-  969 (95.59/58.59)	SL......ANL..ATRlPGFTNTAAYlrqqlHQCDR.................NNPIDA...CspVSDNMAAQLQDAEGELHEE...IEKL....LTSGTSVDRPTMDRLFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.62|      22|      24|     133|     156|       2
---------------------------------------------------------------------------
  102-  127 (35.22/15.14)	PSRLMPKNEPSNLTdmssPASTKGLP
  133-  154 (44.40/29.56)	PPMPMPKRRPRFVV....PPALKDTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.40|      98|     229|    1128|    1240|       3
---------------------------------------------------------------------------
 1128- 1240 (149.95/106.94)	HTSL..PLETPAFRDNMLEllrllvlldPPSVVQGLGMKS.PEPALNGLFAQITTkllLP.DAGEESQLTFETVLELANEF..TLPfCQLKLS...VGLSADTTTSPGGGEQTLSQvdMFSR
 1366- 1472 (142.45/75.32)	HTTAnePMSAPAQSTNAMK.........PPANATAFEIRArILVALSGLTLELDN...LPlDNAQTGRVLREQVFDLALLLvdTLP.EDLRLQcvrVLLTGGTTQSPASSDARLRY..LFSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      12|     225|       8|      22|       6
---------------------------------------------------------------------------
    8-   20 (20.36/15.76)	GVQpRPPQQRTLS
   25-   36 (24.08/ 7.23)	SVQ.RPTHQRTLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11451 with Med12 domain of Kingdom Fungi
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