<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11449

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSDYDTNTLLNNNISSIAFRVYEPSQEQAQTFPSAAADIETELRSRGHIIFYDATKRVVWYFYVPRKDAAPSDNNDDLLGSSVEAAGATLLTVEEGSFEPISLFKGRMQGQQAANTPTSSSSSSSALDASLRNPPTTSSDSDVKSAAAGVSDIKSICSVALKDAYEQFITAVLSTILASFCNRTAAIPLNNRTVLLPAKVTRDGQSERAHDMETAVVGTFRLYLTTTGALVMSLSLSCCEGLLSVNEPLSPNQIDLGSQILAAPFGVLANYQGFMGGGLSYPELGLGQTPDAQLWRNTDARSSQWRDTCIKILQSRGLSPALLQSCPWIALQMIRRKPGDFRADGKMTPLPSTLATISWPAVLCFRKKSVLLARNNGLGDSVLVAQDETSDFLGEARTWFQLGVDREEIVAKRRKEREAAASKEIPAALPTQQANGHSPIGLRRASNAATAGAMYPTPPDGVQNPLGITSSIDGTTSSPGAPGTTMAMVDIDTTMADGAIHEPVIANSGHHSETYGDGWNSNENKRERADSFLADENDNLFGDIGPDMFGDADITDADFNFFDEEGGDGPDLSGLSDLNMADAPGANAILPAPVPEPAKAMVPAMETKPQPSPPVFAKPELKHARSSLMDEGKQKSTLENAAGVKRESSPFDPDTVYKRVRASLGDIRSTPSKTPARKGSVFDSVDFDPVLPLVNKKYEQGGRFDCSPTLRGLPQEVSTQSIFQGPPTTDYLRRHGKHRKSLKPTEHTSALIRTITGNLEHSSLRSSPGKLEDLASDADDISLVSDLDDSSVTSDEPTSPFKSSIRRLNVDDDVVSHVTSLKDIESVEDSDPALALELPKLAKAEASEVLITKYFEDAESLPIYLSLPDEDLITIAQIVTEQASTGILKVRDAHASTLNTAIVSESRRQLSSLSRNALQTLRQVIPAGLGDFKSCNFRGVVDVPDVPLLGPPNRLHTRPANPRENAEPPKPNNLFQIPAPHMELRRAEARLSVLPASIQFWESLGLGPAQGTKDVNVVCVFPHWDGMMEIAAAFLDRMRNVYELLKLGSFERLPSSAKVADGLVPFEADKIATSPGTVSPHIVAGLADRMEALNQGLLSVDAAQKNFLIYFVYPPDHPGSIVEACTAFQQLFEMYRRSLIDRRQTPVNELVLQLVPLDFLTSPAGMVEPTPSETMRLAIETYDRCTLFGGPMPSPAIMLEQALPRGIDFKLTNTSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMAVSYNLGRKGKPLSTSLNDVCHEIWETTHDLISKWKVHWRVVISKCGFMDAQEIAFWQGLAQTESAATVSLTLISVDTNPSLQLIPPAIKVAVTASSTFYSTPVSTPQASILSPEQSGTPVTPMKDNPANAVTPGGTPGDGAAEPAEGDAILLDVTDQTWGAVLAHRLSNSSSPGELNPALISGYLVKRGGTKLEDPPVAMEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGIVDRATDIRPWHIAAAEKGVRALYLLM
Length1518
PositionKinase
OrganismColletotrichum chlorophyti
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum.
Aromaticity0.06
Grand average of hydropathy-0.259
Instability index47.57
Isoelectric point5.09
Molecular weight164196.33
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11449
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.77|      38|     305|     336|     373|       1
---------------------------------------------------------------------------
  336-  373 (67.86/31.74)	IRRKPGDFRADGKMTPLPSTLATI.SWPAVLCFRKKSVL
  646-  684 (60.91/27.84)	VKRESSPFDPDTVYKRVRASLGDIrSTPSKTPARKGSVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     284.99|      76|     679|     691|     775|       2
---------------------------------------------------------------------------
  691-  768 (119.99/67.57)	PVLPLVNKKYEQGGRfDCSPTLRGLPQE..VSTQSIFQGPPTTDYLRRHGKHRKSLKPTEHTSALIRTITgNLEHSSLRS
  852-  922 (90.42/44.49)	....LITKYFEDA...ESLPIYLSLPDEdlITIAQIVTEQASTGILKVRDAHASTLN.TAIVSESRRQLS.SLSRNALQT
  946-  997 (74.58/39.00)	PDVPLLGPPNRLHTR.PANPRENAEPPK....PNNLFQIPAPHMELRR.AEARLSVLP......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.71|      27|     174|      74|     119|       3
---------------------------------------------------------------------------
   74-  107 (40.24/46.79)	SDNNDDLLGSSVEAAGATlltveegSFEPISLFK
  778-  804 (47.48/18.24)	SDADDISLVSDLDDSSVT.......SDEPTSPFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.14|      38|     915|     276|     314|       4
---------------------------------------------------------------------------
  276-  314 (67.72/46.85)	FMGGGLSYPELGLGQT.P...DAQLwRNTDARSSQWRDTCIKI
 1189- 1230 (62.42/37.07)	LFGGPMPSPAIMLEQAlPrgiDFKL.TNTSSSSLMHENTCIHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.07|     114|     306|    1000|    1121|       8
---------------------------------------------------------------------------
 1000- 1121 (177.90/137.57)	IQFWESLGLGPAQGTKDVNVVCVFPHwDGMMEIAAAFldrmrNVyELLKLGSFERLPSSAKVADGLVPFEADKIAT....SP.GTVSPHIVA..GLADRMEAlNQGLLSV.DAAQKNFLIYFVYPPDHPG
 1308- 1429 (173.17/109.36)	IAFWQGLAQTESAATVSLTLISVDTN.PSLQLIPPAI.....KV.AVTASSTFYSTPVSTPQASILSPEQSGTPVTpmkdNPaNAVTPGGTPgdGAAEPAEG.DAILLDVtDQTWGAVLAHRLSNSSSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.43|      22|      23|     537|     559|       9
---------------------------------------------------------------------------
  537-  559 (38.92/28.52)	DEN..DNLFGDiGPDMFGDADITDA
  560-  583 (37.51/22.43)	DFNffDEEGGD.GPDLSGLSDLNMA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11449 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKRRKEREAAASKEIPAALPTQQANGHSPIGLRRASNAATAGAMYPTPPDGVQNPLGITSSIDGTTSSPGAPGTTMAMVDIDTT
2) DGAIHEPVIANSGHHSETYGDGWNSNENKRERADSFLADENDNLFGDIGPDMF
3) DITDADFNFFDEEGGDGPDLSGLSDLNMADAPGANAILPAPVPEPAKAMVPAMETKPQPSPPVFAKPELKHARSSLMDEGKQKSTLENAAGVKRESSPFDPDTVYKRVRASLGDIRSTPSKTPARKGSVF
4) PQASILSPEQSGTPVTPMKDNPANAVTPGGTPGDGAAEPAEGDA
5) QEVSTQSIFQGPPTTDYLRRHGKHRKSLKPTEHTSALIRTITGNL
6) QGQQAANTPTSSSSSSSALDASLRNPPTTSSDSDVK
413
499
555
1361
717
111
496
551
684
1404
761
146










Molecular Recognition Features






MoRF SequenceStartStop




1) DITDADFNFFD
555
565