<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11433

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMAGQAAPMEEIIWRSPQHVQMMGGYLHSNNILFYFAESTFFDPQSNNGILATQATYNESLRHVVETRATFEGKLKQMQGLEFIVSFDPLEAAAQSNPNRFDFEPNNIWVIRKQERRKRSGMEDEVTVIATYFVVGDTIYMAPSVASVVGNRIVSCNLCGLEPALQVVRTLNANSPFFFQLTAVTSLSRLLKTASTLPTFTPSTGHTYLPPTARTTEPGQQASQQSKENTPMPDATQSSAGETQSTGKAGLGVTTTSSTFKDTRNLAEAFHLFTKYGDEFMDEQPLTGEPGSFILSRVGESDRAAGAAEKPASKATLGTGMNTPSGLRGRSTTPQVRIDTPGKASEKSSAPPTPGDSKGKKKKNRIAS
Length367
PositionHead
OrganismPenicillium subrubescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.463
Instability index48.91
Isoelectric point8.42
Molecular weight39776.18
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11433
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      14|      15|     329|     342|       1
---------------------------------------------------------------------------
  329-  342 (25.42/14.56)	RSTTPQVRIDTPGK
  346-  359 (25.74/14.84)	KSSAPPTPGDSKGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.00|      17|      18|     181|     197|       2
---------------------------------------------------------------------------
  181-  197 (27.79/14.18)	TAVTSLSRLLKTA.STLP
  200-  217 (27.21/13.75)	TPSTGHTYLPPTArTTEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.49|      18|      18|     248|     265|       3
---------------------------------------------------------------------------
  248-  265 (29.34/16.36)	AGLGVTTTSSTFKDTRNL
  268-  285 (33.15/19.27)	AFHLFTKYGDEFMDEQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.62|      12|      55|      98|     111|       4
---------------------------------------------------------------------------
   98-  110 (18.59/18.90)	NRFDFEpNNIWVI
  117-  128 (20.02/ 7.96)	KRSGME.DEVTVI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11433 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDEFMDEQPLTGEPGSFILSRVGESDRAAGAAEKPASKATLGTGMNTPSGLRGRSTTPQVRIDTPGKASEKSSAPPTPGDSKGKKKKNRIAS
2) TPSTGHTYLPPTARTTEPGQQASQQSKENTPMPDATQSSAGETQSTGKAGLGVTTTSSTF
276
200
367
259










Molecular Recognition Features






MoRF SequenceStartStop




1) AFHLFTKY
2) PTPGDSKGKKKKNRIAS
268
351
275
367