<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11429

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLSDTASPDQWRTFVQRCLAHRVDVDEFKDLSKLMQNRSPLKENDLLDLLLEARAASSIAWDPLLPVYVDGLCKVGQVKAASALRRLLAHSSIRQKSHSKPNMSTLMTDIKVIQDVMLSISTGAIPRRIAEAAELYDATVDWIVAFVEWHNHGLSQQTGGLMSSPDAVSLFESLGILLAALSGTSKGLETLSSDYQQELKTKLGQALISYLPLCVDVSLPLRHRLDTLQKEFNLYGEQPSKQLDHPTIEGMNVNALQFEASVMDGPVINTRAGLYVYLNSMLVGRPLIDDSMLINYLTNRYEGHQEVLVVEITTAAFDVLSNGVHRNESSRTMFLFRTFLVNKLPAFFAAMTAASMVPIPMEMYITQALNRLDPNSFPSFSQMFSMQGSSILSDARQEFLFACASHRLIQESSIERLLGENPMQTVPVGGPYQKDDLVSQINSRPERAEQLIGEIESMEGNAGAIVGAITEVMFNLCNQKETMTLKNICNSLSRRPQTLDVILMFRTAKQVLQPLCALLDSWRWDEDQGENQPVYDEFGSILLLVLVFKYRYDLSPADMGITSNDSFLLKLLDRGSCSQKLTELSEKQNKDLGSWIGALFIAEGINEETMSTCSPQEFYMLVATLFDQSLGACESGKMDFETLKGGFEYLLEPFLLPSLVVALTWLGNHIWQSETEPEIPLKTLYSLIKPSSISGEAQAIHKTVLHITARPLEEQLKDVRTRHQARQNIDKISDIKPILDALDPYLSFRRVGSCLRSELEVWAAPAAGGFLGSIRGTLQSLTLWSASSGISLQPQSYTHRQLLAGIRILGSARVLGALIDELKQQTEAGSGDLALDIAATMICAPMPESFAVDQNSCHPVDQSKESLPRCAILTLRDALSLQHQNVPKISEKEPLRAEVIVRLWRRVSLLAAPPSRVSNIDVSNIIQNMELGVGGQDRMNLDATGVSGTGVGHDDPANIDQMLDKATAAAAAGMDGVVGQDIGLDSSVTGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1019
PositionTail
OrganismPenicillium subrubescens
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.055
Instability index47.19
Isoelectric point4.91
Molecular weight112193.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.36|      78|     155|     245|     335|       1
---------------------------------------------------------------------------
  245-  335 (109.99/129.10)	HPTIEGMNVNALQFEASVMDGPVintrAGLYVY..LNSMLVGRPLIDDSmLINYLtNRYEGHQEVLVVEITTAAFDvLSNgvhrneSSRTMFL
  406-  485 (129.37/103.06)	HRLIQESSIERLLGENPMQTVPV....GGPYQKddLVSQINSRPERAEQ.LIGEI.ESMEGNAGAIVGAITEVMFN.LCN......QKETMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.98|      31|      69|     915|     945|       2
---------------------------------------------------------------------------
  915-  945 (52.86/34.64)	S..RVSNID.VSNIIQNMEL..........GVGGQDRMNLDATG
  947-  986 (30.94/17.08)	SgtGVGHDD.PANIDQMLDKataaaaagmdGVVGQD.IGLDS..
  988- 1017 (37.18/22.08)	....VTGMDaIDDVLNAADM..........AVGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.69|      32|     154|     716|     751|       3
---------------------------------------------------------------------------
  716-  751 (46.93/57.53)	LKD.VRTRHqarQNIDKISDIKPILDALDPYLsFRRV
  875-  907 (51.76/45.30)	LRDaLSLQH...QNVPKISEKEPLRAEVIVRL.WRRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.54|      20|     299|     212|     239|       4
---------------------------------------------------------------------------
  212-  239 (27.53/36.06)	PLCvdvSLPLRHRLDTLQKEfnlygEQP
  514-  533 (42.01/26.16)	PLC...ALLDSWRWDEDQGE.....NQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.63|      44|     126|      34|      77|       6
---------------------------------------------------------------------------
   34-   77 (75.32/48.41)	LMQNRSPLKENDLLDLLLEARAASSIAWDPLLPVYVDGL.CKVGQ
  161-  205 (66.32/41.71)	LMSSPDAVSLFESLGILLAALSGTSKGLETLSSDYQQELkTKLGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11429 with Med5 domain of Kingdom Fungi
Unable to open file!