<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11420

Description Uncharacterized protein
SequenceMSTLPSSTGNQTWTSYTRPASTNEPRPSMAVAPAAPAQQLIDLSASDGGPLDSEQPHKRPRLDTNVAALGHDGRTPSKSAEARSVILNGSTARTTAVSGRSRPAYSFQELVTDTYGGVAFTANATPGSQTPKPPSPPPFPVRPWMHAPARQSQVENVGPPEDTRSRDVQTNPYRPEIPTIAPRLNREKVADYSPWSRLGNHPEDKLTEFAVKQGYYDKIPGSSNNDLQPNTSKLSGHLKNRSGLQLLSAVFAAALDKRQVHDKISSTSTFKPPPRVTLTDNKREAWLRDLANSAVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSHGLEIKWVREWTIGVQQFIEGVIGACGKEGWRSKMTYAVRLAARLFFENLLDQDCYLDWYMSSIEASTLDVFPIWLAMLSIYWENLVRFRQRGRRLSEALLEKLREATLSEYKAHLQPLIDRVSVIVRRLCQNHSPCVILPRSWDRYQDIISSLLMSDDPKEKALFQSLVLRNARVQRPRAYISNSRRSPQQQIIKLLDSSRDAYNIGALSHTCLSIMPNRGELVSVLLKWTASPFRQGIIRVYIAVRLLRKWKRSGMDIDAFIFSFLTQTSIGQTAHMINIYHTIVELIRSHTFSVGRYLQWLVARGAVEQYRQGSSPDSHVPVDIDLLFHIPSSRLPRHLRNLRDTLMTRAGLLLSSETAILQGIKGELKKRLPQVLRKDDIEEHKMAIDLERNNLTWSIKADISQWIRAAVSEHYEYGPSYQQKIYHHEGSIEVSSLTHEEFLTIRSTLEQYGDLSMLADILINASNSDDVQLLTCGADTLNCHFGCFTVIGALNDLFRNFYEAFLRVKHNPQPVYDLAYSLCEVARRLPNGVNSLLVLRQALSRADRNLALAACSPVSDHVAETLSDSNPSFNEDMDQLLSSGNSMDETTMMIVFQKLIQQLVLYDEKDASMPGTVCRHLVQLRSFNPKHFDLLLVQWLEATIKTTSRPKLSRTLRPLVSIGCVTLPAFAILIKKVLVPDLLNPTVPEPLELLVDFLELLVPVHDLGPVCDFLSYRFRIAQEEFLCEHSHEALGVIQDAVSQCTQAQSKDLLDDQKPLVRYMVPLLREIIVRHPDDITLDTIRTLVKGYPAFGLVVRKTVDMLLNDNNQGSLDFLTEAATTIKKTDNLSLPLCQMKLQILFNEKHSDDIMNTIVDLMYKSAIADVRAGHTYWLDLVSTMGQEAAEQIRQRAEKEFFSVAQSDSALEKDSESERLDLQENARVYLAVIDGLAYSIPEEGVPSVGPPLVEKLNSLLHKLFAMHVNVRNLSELRNHTSPGVATHSISACEENFLFWFTAILQMIRIHRAAFDQPASSTNNRPGAFIDLSRTLIIICCLALSRTPMGFTVQPRLDLSALPPFNTSTSEVRTENTIQTYALDMASSLVDSLPDEARQQCANFIRERFPPSLHVQNDPRLLFLFGPVSETFAPGSVSVSSPASTLTPSANPPAMSAVNTGTVVEDYSAISNRLRVQSRGRIVGSYSLRPWEMLEEAAPVVGANDTAIDLNLFGARKVRDY
Length1570
PositionKinase
OrganismTalaromyces atroroseus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi.
Aromaticity0.07
Grand average of hydropathy-0.225
Instability index47.95
Isoelectric point8.18
Molecular weight175727.86
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11420
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     301.60|     119|     370|     791|     936|       1
---------------------------------------------------------------------------
  791-  836 (42.50/34.62)	............................................................................................................SLTHEEFLTIRSTLEQYGDLSML....ADILINASNSDDVQLLTCGADTL
  844-  936 (77.42/107.50)	TVIGALnDLFRNFYEAFLRVkHNPQPVYD.LAYslcevarRL.........PNGVNSLLVLRQALSradrnlalaACSPvsDHVAETLSDSNPSFNEDMDQLL.......................................................
 1041- 1178 (181.67/139.59)	TVPEPL.ELLVDFLELLVPV.HDLGPVCDfLSY.......RFriaqeeflcEHSHEALGVIQDAVS.........QCTQ..AQSKDLLDDQKPLVRYMVPLLReiivrHPDDITLDTIRTLVKGYPAFGLVvrktVDMLLNDNNQGSLDFLTEAATTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.88|       9|      35|     689|     699|       2
---------------------------------------------------------------------------
  689-  699 (13.62/11.16)	RLPRHLRnlRD
  726-  734 (17.25/ 7.29)	RLPQVLR..KD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.69|      46|     786|     589|     683|       3
---------------------------------------------------------------------------
  339-  384 (82.04/42.08)	IRAFKRKGTSGSLSHGLEI.....KWVREWTIGVQQFIEGVIGACGKEGWR
  616-  666 (72.65/148.16)	IFSFLTQTSIGQTAHMINIyhtivELIRSHTFSVGRYLQWLVARGAVEQYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.17|      58|    1341|      16|     198|       4
---------------------------------------------------------------------------
  126-  198 (93.66/209.68)	PGSQTPKPP....SPPPFPVRPWMHAPArQSQVeNVGppedTRSRDvqtnpyrpeIPTIAPRL...NREK.VADYS..PWSRL
 1476- 1543 (87.51/16.38)	PVSETFAPGsvsvSSPASTLTPSANPPA.MSAV.NTG....TVVED.........YSAISNRLrvqSRGRiVGSYSlrPWEML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      27|     841|     529|     571|       5
---------------------------------------------------------------------------
   25-   51 (48.98/19.45)	PRPSMAVAPAAPAQQLIDL..SASDG...GPL
  531-  562 (37.71/39.35)	PRAYISNSRRSPQQQIIKLldSSRDAyniGAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.80|      23|     840|     452|     495|       6
---------------------------------------------------------------------------
  452-  474 (36.61/55.69)	LLEKLREATLSEYKAHLQPLIDR
  502-  524 (36.19/11.37)	IISSLLMSDDPKEKALFQSLVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.26|      19|      42|     209|     229|       8
---------------------------------------------------------------------------
  209-  229 (30.96/29.10)	FAV...KQGYYDKIpgSSNNDLQP
  251-  272 (29.30/18.64)	FAAaldKRQVHDKI..SSTSTFKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.74|      13|     790|     671|     683|      12
---------------------------------------------------------------------------
  671-  683 (25.26/13.39)	PDSHVPVDIDLLF
 1460- 1472 (25.49/13.58)	PSLHVQNDPRLLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11420 with Med12 domain of Kingdom Fungi
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