<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11417

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPSDAITNISAINGFSVIHWRIYTEEAAIGNLASEIAPTNGYNILRHLSRLKDLEIQLRNLDCLVSCYPRRLGLWIFSPSPGFENLLPLTRDSAVQGSRESTKLTLGASSLKVSASGSITAADLIRSLSADGLTPAGGTPGQSRAPGPGPRSGDTYAIYASFITAVAGAIGLQLTRRHNAIPLGTRTFFTALERSFYDNPTILNDDACSIPALTTLRIELVQTGKIIAALHTVYQDGISRLGGPDFTKISPANVQPNIDVWLAPNGTVARVITVDTTLSTAFAPKQAKNDVSARQITEAKQRVWKATVLEWMSNIGLPVDSSENEHWIEVEVSEPFYARLAADHLRKMDDGQSSSPLKRILWPSGYCFRRKKVSSSSYSDKLYSITTDSVDPLHFAENWLETATLRHEKPTDRSSKVPEVIKVSSISKSEVPEKIESLARVVHYPDLQGAGSVYPTPPDGAQVSGINPIGSDTLGTDGQEMALSHISDSAKQPEHVNEDSSGEAALQPRNELEVGTGLYDTNDDDGLFSDMNDRDFATKGITDADFNFFDDDEMDDFLADDPKTEHPQDIQHPSLADGAEIQFLQEDVKADQVAPKDDRIEQLREPHSPNKMEIESELKVDTQHPTAEPRNPTFKGPSSIILEEVMSTSLSPVDIKKILFSKDTKPSGDINKISRPSNSDFEKKQSRYNAISFRQDMSLSDQKYANAGRFFFMANKECDESTNLAPGIPTIGFPRGRKPGPRTISEEGSADARQSDSVQTVQRSASVSSDETSLDSSDDYSETETSPVRATTLKRKRPLSEAEKSTTSSMERLSITSEAESHVSKEDTSIFLGNFFSVFADWSLVGYFSARQSSTSSISSRKEDQMQVAQLVVDQFTQSSLCHNIDGWESVLDLENEAVNLHTCLEDVTAIGETEKLDLKTYVSLHDIQQAVIETPSTRPNLQRRDIKGSITKLPPAHLRIHRGRDFLEVLPTSMPFWETFGLAPASGQKDISAYCICPQFLGDEADAFLTRLEFLYSSCNLGLWNIANGDGAYVRTMQSLRSLCEGLGNALSKAPPIKENFVVYIINPFTHGTAFADICSTFLQLFHKYIGDVDKAYAKSQLNELVLQIVPLSFVFSSTSLVVPTQSQYLNLALEVYSRCPPKDANTGIVGYAPPVVLANAVPKAINFRVTSERFSPFQEGRCLHVAVSRSVDQRWISAAWSDNSGSCQITMSYCVRSRGSNVNRKVSEIRQEIWEATKDLMERTQTRWRVLLVRTEPIDQEEIDVWTGFAERYNQAKTLPVELTLFSANIAPGLCLELPAGQLHANAMNPMASTPATTPCGGVSSPDQIGVATPASGGFGSLSYNNTAVTPTDTPSGLIDPDSEAVLIDACEESWAIILSHRLSNSTYMTEYKPALVSGYLLRRKGANDSQGVAAMSLNLVHTSRPAAFHEVVLKEALINYRDLATLARAKGTLHVQHNTLPWHIATAVKGQELLSYIL
Length1483
PositionKinase
OrganismTalaromyces atroroseus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi.
Aromaticity0.07
Grand average of hydropathy-0.327
Instability index52.12
Isoelectric point5.21
Molecular weight162791.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11417
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.78|      19|     847|     134|     156|       1
---------------------------------------------------------------------------
  135-  153 (38.78/24.92)	LTPAGGTPGQSRAPGPGPR
  726-  744 (39.00/12.88)	LAPGIPTIGFPRGRKPGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.83|      30|     106|     559|     594|       3
---------------------------------------------------------------------------
  536-  558 (30.39/26.69)	......RDFATKGITD.ADFNFFDDDEMDD
  564-  593 (50.86/32.84)	PKTEHPQDIQHPSLADGAEIQFLQEDVKAD
  597-  623 (42.58/23.45)	PKDDRIEQLREPHSPNKMEI...ESELKVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.00|      52|     207|     410|     490|       5
---------------------------------------------------------------------------
  200-  258 (75.60/31.15)	DNPTilnDDACSIPALttLRIELVQTGKI...IAALHTV..YQD..GISRL..GGPDFTKISpaNVQP
  410-  470 (68.40/78.73)	EKPT...DRSSKVPEV..IKVSSISKSEVpekIESLARVvhYPDlqGAGSVypTPPDGAQVS..GINP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      22|     996|     259|     286|       7
---------------------------------------------------------------------------
  259-  280 (38.69/19.43)	NIDVW..LAPNGTVARVITVDTTL
 1266- 1289 (32.71/14.26)	EIDVWtgFAERYNQAKTLPVELTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.45|      23|     996|      60|      84|       9
---------------------------------------------------------------------------
   60-   84 (40.96/34.43)	LRNLDCLVSCYprRLGLWIFSPSPG
 1012- 1034 (43.49/28.71)	LTRLEFLYSSC..NLGLWNIANGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.17|      39|     996|     158|     197|      10
---------------------------------------------------------------------------
  158-  197 (62.22/39.96)	YAIYASFITAVAGAIGLQLT.RRHNAIPLGtRTFFTALERS
 1155- 1194 (64.94/37.65)	YAPPVVLANAVPKAINFRVTsERFSPFQEG.RCLHVAVSRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11417 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQGAGSVYPTPPDGAQVSGINPIGSDTLGTDGQEMALSHISDSAKQPEHVNEDSSGEAALQPRNELEVGTGLYDTNDDDGLFSDMNDRDF
2) NFFDDDEMDDFLADDPKTEHPQDIQHPSLADGAEIQFLQEDVKADQVAPKDDRIEQLREPHSPNKMEIESELKVDTQHPTAEPRNPTFKGPSSII
3) STNLAPGIPTIGFPRGRKPGPRTISEEGSADARQSDSVQTVQRSASVSSDETSLDSSDDYSETETSPVRATTLKRKRPLSEAEKSTTSSMERLSITSEA
4) TKPSGDINKISRPSNSDFEKKQSRYNAISFRQDMSL
448
549
723
666
538
643
821
701










Molecular Recognition Features






MoRF SequenceStartStop




1) DFATKGITDADFNFFDDDEMDDFLAD
2) DIKKILFSK
3) LKRILWPSGYCFRRKKV
537
656
359
562
664
375