<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11416

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDVSASASRDWGNSYNRHGSNGESNLQHDNSLEKADRTSRSVNGFKSDDRKQSETSIVQGNGKPGAFTGKAQQEWAPELLHITQGFFPYAQLVNRAVQQCYNDLCDVITELAEAQGSSQPQQSSQNSFTNGKSMGNQDAGAVQKRIRILDFTQAKRTEFIKLLVLSQWSRQAVDVSKLIDLQNFIRTRHGAYQTAVQRVADMKRDLVRAQVANPDLQTALEVLTTGRVADMPEFGYKPPKPLSSRRLLATLQRINRIISTRLVTCEDIPISLHNYWVHDGRVTFAVQGGFELDLSIAEEDVSSQFYFIDLRFLFSPSSPIPKGRFFNELDLQINNILKTKGLKGCFDFIHNLVLVNKINILFKQAIDLSRGQWTGALRVELLHRTLVVHYWPDKSGPKSWIEIGVLSGRHRRQNISCLGLRWLREGKESDSSYIHFDTESLSMETILRSVIAIHSSHLLHSVYERIRTQKLFANYQLSINIQMSKIEPGNCRLHVQLTESRYLDASLEPVSGAMCIHTRPSLLCRLDKGGASDDDFVNRISRLRGIAAMEEIESDAKIFGWESVDHRKFKVDIRRAFPNNILRASFFRNRLWGNSWIVAATTSLSGDDWWILHLKPRSAPHSEVFDQIRTVSGGFSIQSTRVLAGDQLLTLRGSKYYFPDLDYSLTGILVMHSNALWLSELGYRSFLPSVEQLQLGSKFEVPCLYLKFDVADLPKALQISPPNGAKNKSYIHNSLTISYHGIDSHTKSAIVVAHGRFYTSLRKLGLKRLKLDECILLRRGGTAFAMRFLIAPGQSIMVDLFERIQRLNIILSLFETLQHNKITVQSVSLSKLSFVYASQEGLLANIFIRLTGPGNAASFDAAALRLHNESLFSLRLDISFNNSSPHNRIKPSLGMILNRTGPGYGVGSVLRLLTLTLPVLRALDSLIAAPRHNSALQIQILVRGAQTYQIYYTGLRFRFLLNASNRRDSVIWTLKDVRSEVLRESEKGVEAKLQEKIYRGKGNGWQGLGNGAVAEVDQVGDLLSELDSCFADVQSPVASLEHVQQVQHGAAEQKSGKAKDKGLNMNGNPKAAPTDRSNAKEADVIMID
Length1094
PositionTail
OrganismTalaromyces atroroseus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Trachyspermi.
Aromaticity0.08
Grand average of hydropathy-0.255
Instability index45.86
Isoelectric point9.34
Molecular weight122644.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11416
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     911.86|     246|     261|     422|     682|       1
---------------------------------------------------------------------------
  250-  419 (198.75/103.17)	..............................................................................................SRRLLATLQRIN..RIISTR....LVTCE...DIPISLHNYWVHdgRVT....FAVQGGFELDLSI.AEEDVSSQFYFIDLRFLFsPSSpIPKGRFF.NELDLQIN.NILKTKGLKGCfDF..IHNL...VLVNKINIL...FKQAIDLSR.GQWTGALRV....ELLHRTLVVHYWPDksgpKSWIEIGVLSG..RHRRQ
  422-  682 (395.35/247.55)	SCLGLR.......WLREGK..ESDSSYIHFDTESLSMETILRSVIAIHSSHLLHsvyerirtQKLFANYQlSINIQM.SKIEPGNCRLHVQLteSRYLDASLEPVSGAMCIHTR...PSLLCR..LDKGGASDDDFVN..RISRLRGIAAMEEIESDAKIfGWESVDHRKFKVDIRRAF.PNN.ILRASFFRNRLWGNSW.IVAATTSLSGD.DWWILHLK...PRSAPHSEV...FDQIRTVSG.GFSIQSTRVLagdQLLTLRGSKYYFPD....LDYSLTGILVM..HSNAL
  685-  942 (317.77/173.23)	SELGYRsflpsveQLQLGSkfEVPCLYLKFDVADLPKALQISPPNGAKNKSYIH........NSLTISYH.GIDSHTkSAIVVAHGRFYTSL...RKL..GLKRLKLDECILLRrggTAFAMRflIAPGQSIMVDLFE..RIQRLNIILSLFETLQHNKI.TVQSVSLSKL..SFVYAS.QEG.LLANIFIRLTGPGNAAsFDAAALRLHNE.SLFSLRLDisfNNSSPHNRIkpsLGMILNRTGpGYGVGS..VL...RLLTLT.....LPV....L.RALDSLIAAprHNSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.18|      20|      23|      76|      97|       2
---------------------------------------------------------------------------
   76-   97 (32.71/25.79)	KAQQEWAPELLH.ITQgfFPYAQ
  101-  121 (31.47/17.65)	RAVQQCYNDLCDvITE..LAEAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.53|      10|      27|     199|     208|       3
---------------------------------------------------------------------------
  199-  208 (19.40/15.22)	QTAVQ.....RVADM
  223-  237 (13.12/ 7.72)	QTALEvlttgRVADM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.06|      23|      30|     143|     165|       4
---------------------------------------------------------------------------
  143-  165 (36.73/22.71)	QDAGAVQKRIRILDFTQAKRTEF
  176-  198 (36.33/22.39)	RQAVDVSKLIDLQNFIRTRHGAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11416 with Med14 domain of Kingdom Fungi
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