<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11411

Description Mediator of RNA polymerase II transcription subunit 11
SequenceMPNASNLLLLTAIFCLLPSNVRAFGAGDIPDFAYLNDKAFRHGDIENILEQVLKNAALAAGGTGLFGFAKQAFQNVSGGSKFDKGDIKKVYFGNWLRDYSQAMDIAGLSKLTAETLVLVVSVLGFMTFGFATEEFEVTADRLGVYLPVEHIDNPKGYAEKEGDARSFHPKLRPPVDPRELEIDPRNGMKNYMATEDQGWDSSTAHIRRTFRACIEHGRRAGGREGSDLWEAYRFLGTGLHTMEDLLAHSNWCEISLRKMGYSEVFCHVGENTDIDTPNGRAPPLVTGTFGSADFLHSLLGEATDHLSQASVTSLAQKMTDASNESNASGNIENLRKIFSKLPMGGSDEKMNEAEELQQESKAYNFNPDDIAPPDVQKRLLEMLAWRDGVFRWITAKIEMIPGLSSLIDELMNALNAYVYTVIAPWLTPILTQATSVLGEGSKAVIDTDDQYEVFDNPDASDPSHSLLSKDHFGLILNEPAGKVAQIVVVYSTELIVKAWADNSDPDEVLDQILKAFHHPYFADGYSSIQHKMFEEMETWIGELSPDETSQTIQALSKDSVRNGKNKRLTEESEEVEAGYGTSSTSQSYTETSSYMQGGRPDTSYGGEESYGGQYQQQSQYNIGYDTDSRGSSHEYDSRDNIQQYPDVDNKQGTYGREDAYDLGRSQYSSSIGYAGSQHYEGYDPNQSRRNPHGSGLGFSNYGRPTGSSYGYNREQQDPYGSDEYRSLPRHRSSGYGEDSREPRRSQYGELEDSYNSQSLEQSTHHRDETYGNKQSERSPYRTEHKPPTHHGHRHNYERDEHENDDSYRNEGYQSFEQRGDYGSGALDDRRFDEGYGRGEDFREEEFGGREVSEQSPPPEVLELDPIWTTSRTARQIHALGEVEKDISRLLSLAASSISLLTLPQTDSPEDNLPQGEERSEQFVLEVSEYFERLDSIQTAIRSSLAHIRHSRIAPSAINAPPPGFLPPSLGVGRYGYEMNGCKATQLSARYPPVPCVRTYGKIADVNNFGCSELPSIKSMDRWKHGPDVLPLLRNSDHHYWVTR
Length1043
PositionHead
OrganismLentinula edodes (Shiitake mushroom) (Lentinus edodes)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Omphalotaceae> Lentinula.
Aromaticity0.10
Grand average of hydropathy-0.749
Instability index51.10
Isoelectric point4.95
Molecular weight116727.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364147

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     204.99|      23|      23|     588|     610|       1
---------------------------------------------------------------------------
  588-  610 (40.69/18.83)	YT....ETSSYMQG....GR.PDTS....YGG.EESY
  614-  635 (31.89/13.13)	YQ....QQSQYNIG....YD.TDSR.....GS.SHEY
  673-  698 (24.37/ 8.25)	YA....GSQHY.EG....YD.PNQSrrnpHGS.GLGF
  703-  724 (33.67/14.28)	RP....TGSSYGYN....RE.QQDP....YGS.DE.Y
  729-  754 (21.14/ 6.15)	RH....RSSGYGED....SRePRRS...qYGElEDSY
  786-  807 (30.76/12.39)	PP....THHGHRHN....YE.RDE.....HEN.DDSY
  812-  841 (22.47/ 7.02)	YQsfeqRGD.YGSGalddRR.FDEG....YGR.GEDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.97|      50|      59|      24|      74|       2
---------------------------------------------------------------------------
   24-   74 (82.59/56.04)	FGAGDIPD..FA.YLNDKAfRHGDIENILEQVLKNAALAAGGTGL..FGFAKQAFQ
   82-  136 (72.39/44.07)	FDKGDIKKvyFGnWLRDYS.QAMDIAGLSKLTAETLVLVVSVLGFmtFGFATEEFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.97|     108|     135|     292|     416|       3
---------------------------------------------------------------------------
  292-  416 (160.11/130.04)	ADFLHSLLGEATDHL...SQASVTSLAQ....KMTDASNES..............NASGNIENLRKIFS.KLPMGGSDEKMNEAEELQQESKAYN..FNPDDIAPpdVQKRLLEMLAwrdgvfRWITakiEMIPglssliDELMNALNA
  423-  554 (157.86/93.02)	APWLTPILTQATSVLgegSKAVIDTDDQyevfDNPDASDPShsllskdhfglilnEPAGKVAQIVVVYStELIVKAWADNSDPDEVLDQILKAFHhpYFADGYSS..IQHKMFEEME......TWIG...ELSP......DETSQTIQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.58|      14|      74|     766|     779|       5
---------------------------------------------------------------------------
  766-  779 (27.47/14.72)	RDETYGNKQ.SERSP
  842-  856 (22.10/10.43)	REEEFGGREvSEQSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11411 with Med11 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) METWIGELSPDETSQTIQALSKDSVRNGKNKRLTEESEEVEAGYGTSSTSQSYTETSSYMQGGRPDTSYGGEESYGGQYQQQSQYNIGYDTDSRGSSHEYDSRDNIQQYPDVDNKQGTYGREDAYDLGRSQYSSSIGYAGSQHYEGYDPNQSRRNPHGSGLGFSNYGRPTGSSYGYNREQQDPYGSDEYRSLPRHRSSGYGEDSREPRRSQYGELEDSYNSQSLEQSTHHRDETYGNKQSERSPYRTEHKPPTHHGHRHNYERDEHENDDSYRNEGYQSFEQRGDYGSGALDDRRFDEGYGRGEDFREEEFGGREVSEQSPPPEVLELDPIW
536
867










Molecular Recognition Features






MoRF SequenceStartStop




NANANA